Comparison of the antithrombotic effect of the new recombinant hirudin HBW 023 and heparin in small arteries and veins

Microsurgery

Volumn 17, Issue 2, 1996, Pages 89-96

  Zhang, Baimeng ^a   Wieslander, Jan B ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b Institute of Plastic Surgery   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A; HIRUDIN; LEPIRUDIN; PROTHROMBIN A;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG FORMULATION; HEPARINIZATION; INTRAARTERIAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; RABBIT; THROMBOSIS PREVENTION;

ANIMALS; ANTICOAGULANTS; ANTITHROMBINS; ARTERIES; BLOOD COAGULATION TESTS; DRUG ADMINISTRATION SCHEDULE; FACTOR XA; HEPARIN; HIRUDIN THERAPY; HIRUDINS; MALE; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN; RABBITS; RANDOM ALLOCATION; RECOMBINANT PROTEINS; SINGLE-BLIND METHOD; SODIUM CHLORIDE; THROMBOSIS; VASCULAR PATENCY; VEINS;

EID: 0029981109     PISSN: 07381085     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2752(1996)17:2<89::AID-MICR3>3.0.CO;2-R     Document Type: Article

References (22)

1. Salemark L: International survey of current microvascular practices in free tissue transfer and replantation surgery. Microsurgery 12:308, 1991.
2. Mitchell GM, Frykman GK, Morrison WA, O'Brien B McC: The nature and extent of histopathologic injury in human avulsed arteries and veins and in experimentally avulsed monkey arteries. Plastic and Reconstructive Surgery 78:801, 1986.
3. Greenberg BM, May JJ, Masem M, et al.: Efficacy of intra-arterial heparin in maintaining microvascular patency: An experimental model. Journal of Reconstructive Microsurgery 5:287-288, 1989.
4. Zhang B, Wieslander JB: A comparison of the early antithrombotic effects between low-molecular-weight heparin and heparin in small arteries following severe trauma. Annals of Plastic Surgery 31:255, 1993.
5. Zhang B, Wieslander JB: Low-molecular-weight heparin exerts an early antithrombotic effect in small arteries and veins following a severe trauma. Microsurgery 13:295, 1992.
6. Wieslander JB, Dougan P, Stjernqvist U, Mecklenburg CV: Effect of dextran-70 and saline on thrombus formation following arteriotomy and intimectomy in small arteries. Microsurgery 7:168-177, 1986.
7. Salemark L, Wieslander JB, Dougan P, Arnljots B: Studies of the antithrombotic effects of dextran-40 following microarterial trauma. British Journal of Plastic Surgery 44:15-22, 1991.
8. Zhang B, Wieslander JB: Improvement of patency in small veins following dextran and/or low molecular weight heparin treatment. Plastic and Reconstructive Surgery 94:352-358, 1994.
9. Fields WS: The history of leeching and hirudin. Haemostasis 21(Suppl):3-10, 1991.
10. Bichler J, Fritz H: Hirudin, a new therapeutic tool? Annals of Haematology 63:67-76, 1991.
11. Just M, Tripier D, Seiffge D: Antithrombotic effects of recombinant hirudin in different animal models. Haemostasis 21(Suppl):80-87, 1991.
12. Raake W, Klauser RJ, Elling H, Zeiller P: Antithrombotic action of recombinant hirudin in a venous thrombosis model. Haemostasis 21(Suppl):127-132, 1991.
13. Doutremepuich C, Lalanne MC, Doutremepuich F, Walenga J, Fareed J: Comparative study of three recombinant hirudins with heparin in an experimental venous thrombosis model. Haemostasis 21(Suppl):99-106, 1991.
14. Mätzsch T, Berqvist D, Hedner U, Östergaard P: Effects of an enzymatically depolymerized heparin as compared with conventional heparin in healthy volunteers. Thrombosis and Haemostasis 57:97-101, 1987.
15. Teien AN, Lie M: An evaluation of an amidolytic assay method: Increased sensitivity by adding purified antithrombin III. Thrombosis Research 10:399-410, 1977.
16. Wanner G, van der Woerd-de Lange J, Weiss L, Hegner N: Partielle thromboplastinzeit, aktivitäten von F VIII und F IX bei klinisch unauffälligen Kindern im vergleich mit gesunden Erwachsenen. Laboratorische Medizin 16:43-47, 1992.
17. Cooley BC, Gould JS: Experimental models for evaluating antithrombotic therapies in replantation microsurgery. Microsurgery 8:230-233, 1987.
18. Zhang B, Wieslander JB: Healing of a severe microarterial trauma. Microsurgery 15:130-140, 1994.
19. Markwardt F: The development of hirudin as an antithrombotic drug. Thrombosis Research 74:1-23, 1994.
20. Weitz JI, Hudoba M, Massel D, Maraganore J, Hirsch J: Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III independent inhibitors. Journal of Clinical Investigation 86:385, 1990.
21. Arnljots B, Berqvist D: Inhibition of heparin-resistant microarterial thrombosis by recombinant hirudin: A specific thrombin inhibitor. Plastic and Reconstructive Surgery 95:894-900, 1995.
22. Khouri RK, Cooley BC, Kenna DM et al.: Thrombosis of microvascular anastomoses in traumatised vessels. Fibrin versus platelets. Plastic and Reconstructive Surgery 86:110-117, 1990.