Effect of artichoke extract (Cynara scolymus L.) on palmitic-1- 14C acid oxidation in rats

Molecular Nutrition and Food Research

Volumn 52, Issue 5, 2008, Pages 589-594

  Juzyszyn, Zygmunt ^a   Czerny, Boguslaw ^a   Pawlik, Andrzej ^a   Drozdzik, Marek ^a  

^a POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Artichoke extract; Hypolipemic activity; Palmitic 1 14C acid oxidation; Phytotherapy; Plant food

Indexed keywords

CYNARA SCOLYMUS; RATTUS;

CARBON; PALMITIC ACID; PLANT EXTRACT;

ANIMAL; ARTICHOKE; ARTICLE; BLOOD; ISOTOPE LABELING; KINETICS; MALE; METABOLISM; METHODOLOGY; OXIDATION REDUCTION REACTION; RAT; WISTAR RAT;

ANIMALS; CARBON RADIOISOTOPES; CYNARA SCOLYMUS; ISOTOPE LABELING; KINETICS; MALE; OXIDATION-REDUCTION; PALMITIC ACID; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 48649087508     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700235     Document Type: Article

References (21)

1. Wegener, T., Fintelmann, V., Pharmacological properties and therapeutic profile of artichoke (Cynara scolymus L.). Wien. Med.Wochenschr. 1999, 149, 241-247.
2. Fintelmann, V., Antidyspeptische und lipidsenkende Wirkungen von Artischockenextrakt. Ergebnisse klinischer Untersuchungen zur Wirksamkeit und Vertraglichkeit von Hepar SL forte an 553 patienten. Z. Allg. Med. 1996, 72, 3-19.
3. Pittler, M. H., Ernst, E., Artichoke leaf extract for serum cholesterol reduction. Perfusion 1998, 11, 338-340.
4. Gebhardt, R., Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymnus L.) extracts. J. Pharmacol. Exp. Ther. 1998, 286, 1122-1128.
5. Goldstein, B. J., Mahadev, K., Wu, X., Zhu, L., Motoshima, H., Role of isulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid. Redox Signal. 2005, 7, 1021-1031.
6. Jimenez-Escrig, A., Dragsted, L. O., Daneshvar, B., Pulido, R., Saura-Calixto, F., In vitro antioxidant activities of edible artichoke (Cynara scolymus L.) and effect on biomarkers of antioxidants in rats. J. Agric. Food Chem. 2003, 51, 5540-5545.
7. Perez-Garcia, F., Adzet, T., Canigueral, S., Activity of artichoke leaf extract on reactive oxygen species in human leukocytes. Free Radic. Res. 2000, 33, 661-665.
8. Juzyszyn, Z., Czerny, B., Pawlik, A., Drozdzik, M., The effect of artichoke (Cynara scolymus L.) extract on ROS generation in HUVEC cells. Phytother. Res. in press.
9. Folch, J., Lees, M., Stanley, G. H. S., A simple method for isolation and purification of total lipids from animal tissues. J. Biol. Chem. 1956, 226, 497-509.
10. Harkness, J. E., Wagner, J. E., The Biology and Medicine of Rabbits and Rodents, Williams and Wilkins Hagerstown, Maryland, USA 1995.
11. Weinman, E. O., Chaikoff, L. L., Dauben, W. G., Gee, M., Entenman, C. J., Relative rates of conversion of the various carbon atoms of palmitic acid to carbon dioxide by the intact rat. J. Biol. Chem. 1950, 184, 735-744.
12. 14C to intact rats. Arch. Biochem. Biophys. 1957, 71, 346-351.
13. Nohl, H., Generation of superoxide radicals as byproducts of cellular respiration. Ann. Biol. Clin. 1994, 52, 199-204.
14. Nohl, H., Kozlov, A. V., Gille, L., Staniek, K., Cell respiration and formation of reactive oxygen species: Facts and artefacts. Biochem. Soc. Trans. 2003, 31, 1308-1311.
15. Mannaerts, G. P., Debeer, L. J., Thomas, J., De Schepper, P. J., Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. JBC 1979, 254, 4585-4595.
16. Hayes, G. R., Lockwood, D. H., Role of insulin receptor phosphorylation in the insulinonomimetic effects of hydrogen peroxide. Proc. Natl. Acad. Sci. USA 1987, 84, 8115-8119.
17. May, J. M., Haen, C., The insulin-like effect of hydrogen peroxide on pathways of lipid synthesis in rat adipocytes. J. Biol. Chem. 1979, 18, 9017-9021.
18. Muchmore, D. B., Little, S. A., Haen, C., Counterregulatory control of intracellular hydrogen peroxide production by insulin and lipolytic hormones in isolated rat epididymal fat cells: A role of free fatty acids. Biochemistry 1982, 21, 3886-3892.
19. Sidossis, L. S., Stuart, C. A., Shulman, G. I., Lopaschuk, G. D., Wolfe, R. R., Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria. J. Clin. Invest. 1996, 15, 2244-2250.
20. Jensen, M. D., Fatty acid oxidation in human skeletal muscle. J. Clin. Invest. 2002, 110, 1607-1609.
21. Wang, M., Simon, J. E., Aviles, I. F., He, K., et.al., Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). J. Agric. Food Chem. 2003, 51, 601-608.