Liposome-mediated gene transfer of endothelial nitric oxide synthase to cirrhotic rat liver decreases intrahepatic vascular resistance

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 8 PART2, 2008, Pages

  Zhang, Zhi Qi ^a   Qiu, Jiang Feng ^a   Luo, Meng ^a   Sun, Yong Wei ^a   Zhao, Gang ^a   Chen, Wei ^a   Liu, Hua ^a   Wu, Zhi Yong ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Endothelial nitric oxide synthase; Gene transfer; In situ liver perfusion; Nitric oxide; Portal hypertension

Indexed keywords

ARACHIS OIL; BUFFER; CARBON TETRACHLORIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; LIPOSOME; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EUKARYOTE; GENE TRANSFER; INTRAHEPATIC VASCULAR RESISTANCE; LIVER CIRRHOSIS; MALE; NONHUMAN; PATHOGENESIS; PLASMID; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; VASCULAR RESISTANCE;

EID: 48549105945     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2007.05244.x     Document Type: Article

References (35)

1. Shah V, Garcia-Cardena G, Sessa WC, Groszmann RJ. The hepatic circulation in health and disease: report of a single-topic symposium. Hepatology 1998 27 : 279 88.
2. Bhimani EK, Serracino-Inglott F, Sarela AI, Batten JJ, Mathie RT. Hepatic and mesenteric nitric oxide synthase expression in a rat model of CCl(4)-induced cirrhosis. J. Surg. Res. 2003 113 : 172 8.
3. Gonzalez-Abraldes J, Garcia-Pagan JC, Bosch J. Nitric oxide and portal hypertension. Metab. Brain Dis. 2002 17 : 311 24.
4. Wu Z, Zhou J, Chen Z et al. [The role of nitric oxide in hyperdynamic circulation in portal hypertensive rats]. Zhonghua Wai Ke Za Zhi 1998 36 : 182 6 (in Chinese).
5. Bosch J, Garcia-Pagan JC. Complications of cirrhosis. I. Portal hypertension. J. Hepatol. 2000 32 : 141 56.
6. Kawada N, Tran-Thi TA, Klein H, Decker K. The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur. J. Biochem. 1993 213 : 815 23.
7. Rockey D. The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 1997 25 : 2 5.
8. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol. Ther. 1995 66 : 387 412.
9. Rockey DC, Weisiger RA. Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance. Hepatology 1996 24 : 233 40.
10. Zhang JX, Pegoli W Jr, Clemens MG. Endothelin-1 induces direct constriction of hepatic sinusoids. Am. J. Physiol. 1994 266 : G624 32.
11. Bauer M, Zhang JX, Bauer I, Clemens MG. ET-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action. Am. J. Physiol. 1994 267 : G143 9.
12. Okumura S, Takei Y, Kawano S et al. Vasoactive effect of endothelin-1 on rat liver in vivo. Hepatology 1994 19 : 155 61.
13. Suematsu M, Goda N, Sano T et al. Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J. Clin. Invest. 1995 96 : 2431 7.
14. Shah V, Haddad FG, Garcia-Cardena G et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J. Clin. Invest. 1997 100 : 2923 30.
15. Rockey DC, Chung JJ. Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension. Gastroenterology 1998 114 : 344 51.
16. Gupta TK, Toruner M, Chung MK, Groszmann RJ. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. Hepatology 1998 28 : 926 31.
17. Shah V, Toruner M, Haddad F et al. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology 1999 117 : 1222 8.
18. Pinzani M, Milani S, De Franco R et al. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 1996 110 : 534 48.
19. Gandhi CR, Sproat LA, Subbotin VM. Increased hepatic endothelin-1 levels and endothelin receptor density in cirrhotic rats. Life Sci. 1996 58 : 55 62.
20. Rockey DC, Fouassier L, Chung JJ et al. Cellular localization of endothelin-1 and increased production in liver injury in the rat: potential for autocrine and paracrine effects on stellate cells. Hepatology 1998 27 : 472 80.
21. Qiu JF, Wu ZY, Luo CX, Yu FR, Zhang ZQ. Construction and identification of polycistron adenoviral expression vector PCA13/FasL-IRES-iNOS. Chin J. Dig. Dis. 2004 5 : 40 3.
22. Clark PR, Stopeck AT, Ferrari M, Parker SE, Hersh EM. Studies of direct intratumoral gene transfer using cationic lipid-complexed plasmid DNA. Cancer Gene Ther. 2000 7 : 853 60.
23. Fiorucci S, Santucci L, Antonelli E et al. NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines. Gastroenterology 2000 118 : 404 21.
24. Mittal MK, Gupta TK, Lee FY, Sieber CC, Groszmann RJ. Nitric oxide modulates hepatic vascular tone in normal rat liver. Am. J. Physiol. 1994 267 : G416 22.
25. Graupera M, Garcia-Pagan JC, Titos E et al. 5-lipoxygenase inhibition reduces intrahepatic vascular resistance of cirrhotic rat livers: a possible role of cysteinyl-leukotrienes. Gastroenterology 2002 122 : 387 93.
26. Rockey DC. Cellular pathophysiology of portal hypertension and prospects for management with gene therapy. Clin. Liver Dis. 2001 5 : 851 65.
27. Rockey DC, Chung JJ. Regulation of inducible nitric oxide synthase in hepatic sinusoidal endothelial cells. Am. J. Physiol. 1996 271 : G260 7.
28. Shah V, Chen AF, Cao S et al. Gene transfer of recombinant endothelial nitric oxide synthase to liver in vivo and in vitro. Am. J. Physiol. Gastrointest. Liver Physiol. 2000 279 : G1023 30.
29. Van de Casteele M, Omasta A, Janssens S et al. In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats. Gut 2002 51 : 440 5.
30. Yu Q, Shao R, Qian HS, George SE, Rockey DC. Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. J. Clin. Invest. 2000 105 : 741 8.
31. Qiu JF, Wu ZY, Zhang ZQ, Luo HF. Experimental study on iNOS gene transfer mediated by liposome to treat portal hypertension in cirrhotic rats. Zhonghua Wai Ke Za Zhi 2004 42 : 428 31.
32. Tomko RP, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc. Natl Acad. Sci. USA 1997 94 : 3352 6.
33. Bergelson JM, Cunningham JA, Droguett G et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997 275 : 1320 3.
34. Thomas D, Suthanthiran M. Optimal modes and targets of gene therapy in transplantation. Immunol. Rev. 2003 196 : 161 75.
35. Kawakami S, Yamashita F, Nishida K, Nakamura J, Hashida M. Glycosylated cationic liposomes for cell-selective gene delivery. Crit. Rev. Ther. Drug Carrier Syst. 2002 19 : 171 90.