Hepatic and mesenteric nitric oxide synthase expression in a rat model of CCl4-induced cirrhosis

Journal of Surgical Research

Volumn 113, Issue 1, 2003, Pages 172-178

  Bhimani, E K ^a   Serracino Inglott, F ^a   Sarela, A I ^a   Batten, J J ^a   Mathie, R T ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Cirrhosis; Citrulline assay; Endotoxin; Nitric oxide; Nitric oxide synthases; Portal hypertension; Wistar rats

Indexed keywords

ARGININE; CARBON TETRACHLORIDE; CITRULLINE; ENDOTOXIN; NITRATE; NITRIC OXIDE SYNTHASE; NITRITE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; HISTOCHEMISTRY; LIVER CIRRHOSIS; LIVER SINUSOID; MALE; MESENTERY; METABOLITE; NONHUMAN; PORTAL VEIN BLOOD; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0043237261     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-4804(03)00163-X     Document Type: Article

References (30)

1. Groszmann R.J. Hyperdynamic state in chronic liver diseases. J. Hepatol. 17:(Suppl 2):1993;S38.
2. Groszmann R.J., Jensen J.E. Pathophysiology of portal hypertension. Kaplowitz N. Liver and Biliary Disease. 2nd ed:1996;494-504 Williams & Wilkins, Baltimore.
3. Esler M., Dudley F., Jennings G., et al. Increased sympathetic nervous activity and the effects of its inhibition with clonidine in alcoholic cirrhosis. Ann. Intern. Med. 116:1992;446.
4. Zimmermann T., Gardemann A., Machnik G., et al. Metabolic and hemodynamic responses of bivascularly perfused rat liver to nerve stimulation, noradrenaline, acetylcholine and glucagon in thioacetamide-induced micronodular cirrhosis. Hepatology. 15:1992;464.
5. Mathie R.T. The hepatic haemodynamic effects of nitric oxide. Mathie R.T., Griffith T.M. The Haemodynamic Effects of Nitric Oxide. 1st ed:1999;297-322 Imperial College Press, London.
6. Lang D., Lewis M.J. Biochemical effects of nitric oxide on vascular smooth muscle. Mathie R.T., Griffith T.M. The Haemodynamic Effects of Nitric Oxide. 1st ed:1999;3-21 Imperial College Press, London.
7. Vallance P., Moncada S. Hyperdynamic circulation in cirrhosis a role for nitric oxide? Lancet. 337:1991;776.
8. Guarner C., Soriano G., Tomas A., et al. Increased serum nitrite and nitrate levels in patients with cirrhosis relationship to endotoxemia . Hepatology. 18:1993;1139.
9. Chu C.-J., Lee F.-Y., Wang S.-S., et al. Hyperdynamic circulation of cirrhotic rats with ascites role of endotoxin, tumour necrosis factor-α and nitric oxide . Clin. Sci. 93:1997;219.
10. Morales-Ruiz M., Jimenez W., Perez-Sala D., et al. Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites. Hepatology. 24:1996;1481.
11. Tanoue K., Ohta M., Tarnawski A.S., et al. Portal hypertension activates the nitric oxide synthase genes in the esophageal mucosa of rats. Gastroenterology. 110:1996;549.
12. Shah V., Haddad F.G., Garcia-Cardena G., et al. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. J. Clin. Invest. 100:1997;2923.
13. Sarela A.I., Mihaimeed F.M.A., Batten J.J., et al. Hepatic and splanchnic nitric oxide activity in patients with cirrhosis. Gut. 44:1999;749.
14. Proctor E., Chatamra K. High yield micronodular cirrhosis in the rat. Gastroenterology. 83:1982;1183.
15. Bredt D.S., Snyder S.H. Isolation of nitric oxide synthase, a calmodulin requiring enzyme. Proc. Natl. Acad. Sci. USA. 87:1990;682.
16. 3H-thymidine incorporation in cultured sinusoidal endothelial cells from rats. J. Hepatol. 31:1999;284.
17. Rockey D. The cellular pathogenesis of portal hypertension stellate cell contractility, endothelin, and nitric oxide . Hepatology. 25:1997;2.
18. Mathie R.T., Ralevic V., Moore K.P., et al. Mesenteric vasodilator responses in cirrhotic rats a role for nitric oxide? Hepatology. 118:1996;435.
19. McNaughton L., Puttagunta L., Martinez-Cuesta M.A., et al. Distribution of nitric oxide synthase in normal and cirrhotic human liver. Proc. Natl. Acad. Sci. USA. 99:2002;17161.
20. Hobbs A.J., Ignarro L.J. Chemistry and molecular biology of nitric oxide synthesis. Mathie R.T., Griffith T.M. The Haemodynamic Effects of Nitric Oxide. 1st ed:1999;297-322 Imperial College Press, London.
21. Kanwar S., Kubes P., Teppermann B.L., et al. Nitric oxide synthase activity in portal-hypertensive and cirrhotic rats. J. Hepatol. 25:1996;52.
22. Fernandez M., Garcia-Pagan J.C., Casadevall M., et al. Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portal-hypertensive rats. Gastroenterology. 108:1995;1487.
23. Michelakis E.D., Dinh-Xuan A.T., Djaballah K., et al. Measurement of nitric oxide and nitric oxide synthase activity. Mathie R.T., Griffith T.M. The Haemodynamic Effects of Nitric Oxide. 1st ed:1999;163-185 Imperial College Press, London.
24. Heller J., Sogni P., Tazi K.A., et al. Abnormal regulation of aortic NOS2 and NOS3 activity and expression from portal vein-stenosed rats after lipopolysaccharide administration. Hepatology. 30:1999;698.
25. Sieber C.C., Groszmann R.J. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology. 103:1992;235.
26. Cahill, P. A., Redmond, E. M., Hodges, et al. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. J. Hepatol. 25: 370, 1996.
27. Sogni P., Smith A.P.L., Gadano A., et al. Induction of nitric oxide synthase II does not account for excess vascular nitric oxide production in experimental cirrhosis. J. Hepatol. 26:1997;1120.
28. Genesca J., Gonzalez A., Segura R., et al. Interleukin-6, nitric oxide, and the clinical and hemodynamic alterations of patients with cirrhosis. Am. J. Gastroenterol. 94:1999;169.
29. Galley H.F., Coomansingh D., Webster N.R., et al. Nitric oxide synthase activity is increased in relation to the severity of liver dysfunction. Clin. Sci. 95:1998;355.
30. Chin-Dusting J.P.F., Rasaratnam B., Jennings G.L.R., et al. Effect of fluoroguinolone on the enhanced nitric oxide-induced peripheral vasodilation seen in cirrhosis. Ann. Intern. Med. 127:1997;985.