Tension generation and relaxation in single myofibrils from human atrial and ventricular myocardium

Pflugers Archiv European Journal of Physiology

Volumn 454, Issue 1, 2007, Pages 63-73

  Piroddi, Nicoletta ^a,b   Belus, Alexandra ^a,b   Scellini, Beatrice ^a,b   Tesi, Chiara ^a,b   Giunti, Gabriele ^a,c   Cerbai, Elisabetta ^a,b   Mugelli, Alessandro ^a,b   Poggesi, Corrado ^a,b  

^a Centro Interuniversitario di Medicina Molecolare e Biofisica Applicata (CIMMBA)   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

Bepridil; Calcium regulation; Cardiac sarcomere; Inorganic phosphate; Myosin; Titin

Indexed keywords

BEPRIDIL; CALCIUM ION; PHOSPHATE; TROPONIN;

ADULT; AGED; ARTICLE; CALCIUM BINDING; CONTROLLED STUDY; FEASIBILITY STUDY; FEMALE; HEART ATRIUM MUSCLE; HEART CONTRACTION; HEART MUSCLE RELAXATION; HEART MUSCLE TENSION; HEART VENTRICLE WALL; HUMAN; HUMAN TISSUE; KINETICS; MALE; MUSCLE FIBRIL; MUSCLE TISSUE; PRIORITY JOURNAL; SARCOMERE; THIN FILAMENT;

ADULT; AGED; CALCIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEASIBILITY STUDIES; FEMALE; HEART; HEART ATRIA; HEART VENTRICLES; HUMANS; KINETICS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOFIBRILS; PHOSPHATES; PHYSICAL STIMULATION; REACTION TIME; SARCOMERES; SOLUTIONS;

EID: 33847624646     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-006-0181-3     Document Type: Article

References (33)

1. 2+ in intact and skinned trabeculae from control and myopathic human hearts. J Clin Invest 82:1578-1584
2. Morano I, Bletz C, Wojciechowski R, Ruegg JC (1991) Modulation of crossbridge kinetics by myosin isoenzymes in skinned human heart fibers. Circ Res 68:614-618
3. Zacharzowsky UB, Shah AM, Haase H, Morano I (1999) Inhibition of crossbridge function in the normal human heart by hypoxic endothelial superfusate. Biochem Biophys Res Commun 262:64-67
4. Mulieri LA, Barnes W, Leavitt BJ, Ittleman FP, LeWinter MM, Alpert NR et al (2002) Alterations of myocardial dynamic stiffness implicating abnormal crossbridge function in human mitral regurgitation heart failure. Circ Res 90:66-72
5. Narolska NA, van Loon RB, Boontje NM, Zaremba R, Penas SE, Russell J et al (2005) Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue. Cardiovasc Res 65:221-229
6. Wolff MR, Buck SH, Stoker SW, Greaser ML, Mentzer RM (1996) Myofibrillar calcium sensitivity of isometric tension is increased in human dilated cardiomyopathies: role of altered beta-adrenergically mediated protein phosphorylation. J Clin Invest 98:167-176
7. van Der Velden J, Klein LJ, Zaremba R, Boontje NM, Huybregts MA, Stooker W et al (2001) Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts. Circulation 104:1140-1146
8. Borbely A, van der Velden J, Papp Z, Bronzwaer JGF, Edes I, Stienen GJM et al (2005) Cardiomyocyte stiffness in diastolic heart failure. Circulation 111:774-781
9. Poggesi C, Tesi C, Stehle R (2005) Sarcomeric determinants of striated muscle relaxation kinetics. Invited Review. Pflügers Arch 449:505-517
10. Linke WA, Popov VI, Pollack GH (1994) Passive and active tension in single cardiac myofibrils. Biophys J 67:782-792
11. Colomo F, Piroddi N, Poggesi, C, te Kronnie KG, Tesi C (1997) Active and passive forces of isolated myofibrils from cardiac and fast skeletal muscle of the frog. J Physiol 500:535-548
12. 2+ changes. Biophys J 83:2152-2161
13. Sachs F (1999) Practical limits on the maximal speed of solution exchange for patch clamp experiments. Biophys J 77:682-690
14. Tesi C, Colomo F, Nencini S, Piroddi N, Poggesi, C (2000) The effect of inorganic phosphate on force generation in single myofibrils from rabbit skeletal muscle. Biophys J 78:3081-3092
15. 2+ reduction in single myofibrils from skeletal muscle. Biophys J 83:2142-2151
16. Cazorla O, Freiburg A, Helmes M, Centner T, McNabb M, Wu Y et al (2000) Differential expression of cardiac titin isoforms and modulation of cellular stiffness. Circ Res 86:59-67
17. Reiser PJ, Portman MA, Ning XH, Schomisch Moravec C (2001) Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles. Am J Physiol 280:H1814-H1820
18. Gordon AM, Homsher E, Regnier M (2000) Regulation of contraction in striated muscle. Physiol Rev 80:853-924
19. ++ binding by bepridil. J Pharmacol Exp Ther 238:502-507
20. MacLachlan LK, Reid DG, Mitchell RC, Salter CJ, Smith SJ (1990) Binding of a calcium sensitizer, bepridil, to cardiac troponin C. A fluorescence stopped-flow kinetic, circular dichroism, and proton nuclear magnetic resonance study. J Biol Chem 265:9764-9770
21. Neagoe C, Kulke M, del Monte F, Gwathmey JK, de Tombe PP, Hajjar RJ et al (2002) Titin isoform switch in ischemic human heart disease. Circulation 106:1333-1341
22. Nagueh SF, Shah G, Wu Y, Torre-Amione G, King NM, Lahmers S et al (2004) Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation 110:155-162
23. Backx PH, Gao WD, Azan-Backx MD, Marban E (1995) The relationship between contractile force and intracellular [Ca2+] in intact rat cardiac trabeculae. J Gen Physiol 105:1-19
24. Stehle R, Kruger M, Scherer P, Brixius K, Schwinger RH, Pfitzer G (2002) Isometric force kinetics upon rapid activation and relaxation of mouse, guinea-pig and human heart muscle studied on the subcellular myofibrillar level. Basic Res Cardiol 97(Suppl 1):I127-I135
25. van der Velden J, Klein LJ, van der Bijl M, Huybregts MAJM, Stooker W, Witkop J et al (1999) Isometric tension development and its calcium sensitivity in skinned myocyte-sized preparations from different regions of the human heart. Cardiovasc Res 42:706-719
26. Moss RL, Razumova M, Fitzsimmons DP (2004) Myosin cross bridge activation of cardiac thin filaments: implications for myocardial function in health and disease. Circ Res 94:1290-1300
27. 2+-sensitivity of force is enhanced in failing human hearts. Cardiovasc Res 57:505-514
28. Morano M, Zacharzowski U, Maier M, Lange PE, Alexi-Meskishvili V, Haase H et al (1996) Regulation of human heart contractility by essential myosin light chain isoforms. J Clin Invest 98:467-473
29. Bottinelli R, Canepari M, Cappelli V, Reggiani C (1995) Maximum speed of shortening and ATPase activity in atrial and ventricular myocardia of hyperthyroid rats. Am J Physiol 269:C785-C790
30. Buck SH, Konyn PJ, Palermo J, Robbins J, Moss RL (1999) Altered kinetics of contraction of mouse atrial myocytes expressing ventricular myosin regulatory chain. Am J Physiol 276:H1167-H1171
31. Li Y, Love ML, Putkey JA, Cohen C (2000) Bepridil opens the regulatory N-terminal lobe of cardiac troponin C. Proc Natl Acad Sci USA 97:5140-5145
32. 2+ on cross bridge turnover kinetics in skinned single rabbit psoas fibers: implication for regulation of muscle contraction. Proc Natl Acad Sci USA 83:3265-3269
33. Brenner B, Chalovich JM (1999) Kinetics of thin filament activation probed by fluorescence of N-((2-(iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz- 2-oxa-1, 3-diazole-labeled troponin I incorporated into skinned fibers of rabbit psoas muscle: implications for regulation of muscle contraction. Biophys J 77:2692-2708