A New Medium-term Rat Colorectal Bioassay Applying Neoplastic Lesions as End Points for Detection of Carcinogenesis Modifiers Effects with Weak or Controversial Modifiers

Toxicologic Pathology

Volumn 36, Issue 3, 2008, Pages 459-464

  Cho, Young Man ^a   Imai, Toshio ^a   Ota, Yoshio ^a   Hasumura, Mai ^a   Takami, Shigeaki ^a   Hirose, Masao ^b   Nishikawa, Akiyoshi ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b Food Safety Commission of Japan   (Japan)

Author keywords

1,2 dimethylhydrazine; aberrant crypt foci; bioassay; colon; dextran sodium sulfate; rat

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CARCINOGEN; DEXTRAN SULFATE; 3 INDOLEMETHANOL; CORN OIL; DEXTRAN; DEXTRIN; GLUCOSE; PERILLA OIL; SODIUM SULFATE; SULFATE;

ADENOCARCINOMA; ANIMAL; ARTICLE; BIOASSAY; BODY WEIGHT; CARCINOGEN TESTING; CHEMICALLY INDUCED DISORDER; COLORECTAL TUMOR; DRUG EFFECT; DRUG INTERACTION; FISCHER 344 RAT; INTESTINE MUCOSA; MALE; METHODOLOGY; PATHOLOGY; PRECANCER; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; VALIDATION STUDY; ANIMAL EXPERIMENT; ANIMAL MODEL; CANCER DIAGNOSIS; CAPILLARY PROLIFERATION; CARCINOGENESIS; COLON INJURY; COLORECTAL CANCER; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL;

1,2-DIMETHYLHYDRAZINE; ADENOCARCINOMA; ANIMALS; BODY WEIGHT; CARCINOGENICITY TESTS; CARCINOGENS; COLORECTAL NEOPLASMS; DEXTRAN SULFATE; DRUG INTERACTIONS; ENDPOINT DETERMINATION; INJECTIONS, SUBCUTANEOUS; INTESTINAL MUCOSA; MALE; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344;

PERILLA; RATTUS; ZEA MAYS;

EID: 48549097778     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/0192623308315358     Document Type: Article

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