On the voltage-dependent Ca2+ block of serotonin 5-HT3 receptors: A critical role of intracellular phosphates

Journal of Physiology

Volumn 586, Issue 15, 2008, Pages 3629-3638

  Noam, Yoav ^a   Wadman, Wytse J ^a   Van Hooft, Johannes A ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; PHOSPHATE; SEROTONIN 3 RECEPTOR; CALCIUM; PROTEIN SUBUNIT; SEROTONIN 3A RECEPTOR; SEROTONIN 3B RECEPTOR; VOLTAGE DEPENDENT ANION CHANNEL;

AMINO ACID SUBSTITUTION; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CONTROLLED STUDY; ELECTRIC POTENTIAL; HIPPOCAMPUS; HUMAN; HUMAN CELL; INTERNEURON; NERVE CELL MEMBRANE CONDUCTANCE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; ANIMAL; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RAT; ANIMAL CELL; ANIMAL TISSUE; BRAIN NERVE CELL; CALCIUM CONDUCTANCE; MALE; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RESIDUE ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELL LINE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; INTERNEURONS; PHOSPHATES; PROTEIN SUBUNITS; RATS; RECEPTORS, SEROTONIN, 5-HT3;

EID: 48549093515     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.153486     Document Type: Article

References (35)

1. 3 receptors. Proc Natl Acad Sci U S A 102, 12595-12600.
2. 3A). J Physiol 507, 653-665.
3. 3 receptors in the central nervous system. Cell Tissue Res 326, 573-581.
4. 3B subunit is a major determinant of serotonin-receptor function. Nature 397, 359-363.
5. 3B receptor subunit. J Biol Chem 274, 30799-30810.
6. Egan TM & Khakh BS (2004). Contribution of calcium ions to P2X channel responses. J Neurosci 24, 3413-3420.
7. Erecinska M, Stubbs M, Miyata Y & Ditre CM (1977). Regulation of cellular metabolism by intracellular phosphate. Biochim Biophys Acta 462, 20-35.
8. 2+ efflux in microsomal vesicles from non-hepatic cells. Biochem J 289, 299-306.
9. 3 receptor stably expressed in HEK 293 cells. Br J Pharmacol 114, 1211-1221.
10. i increases neuronal survival in the acute early phase following excitotoxic/oxidative insults. J Neurochem 70, 1850-1858.
11. Glinn M, Ni B & Paul SM (1997). Inorganic phosphate enhances phosphonucleotide concentrations in cultured fetal rat cortical neurons. Brain Res 757, 85-92.
12. 3A receptors. J Physiol 522, 187-198.
13. Guynn RW, Veloso D, Lawson JW & Veech RL (1974). The concentration and control of cytoplasmic free inorganic pyrophosphate in rat liver in vivo. Biochem J 140, 369-375.
14. 3 receptors in rodents. J Neurochem 75, 240-247.
15. 3 receptor. Biophys J 84, 1720-1733.
16. 2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors. Mol Pharmacol 46, 1120-1128.
17. 2+. J Physiol 568, 381-396.
18. 3A receptor contributes to receptor desensitization mechanism. J Biol Chem 281, 21781-21788.
19. Hussy N, Lukas W & Jones KA (1994). Functional properties of a cloned 5-hydroxytryptamine ionotropic receptor subunit: Comparison with native mouse receptors. J Physiol 481, 311-323.
20. 3 receptors in the rat hippocampal dentate gyrus: A patch-clamp study. J Neurophysiol 71, 1935-1947.
21. 3 receptors. Nature 424, 321-324.
22. 3 receptor, a serotonin-gated ion channel. Science 254, 432-437.
23. McMahon LL & Kauer JA (1997). Hippocampal interneurons are excited via serotonin-gated ion channels. J Neurophysiol 78, 2493-2502.
24. 3 receptor is present in different subpopulations of GABAergic neurons in the rat telencephalon. J Neurosci 17, 3157-3167.
25. ATP channels as molecular sensors of cellular metabolism. Nature 440, 470-476.
26. 3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 310, 101-111.
27. 3E. Mol Pharmacol 72, 8-17.
28. 3 receptor. Trends Pharmacol Sci 26, 587-594.
29. 3 receptors in visual cortex. J Neurosci 17, 8353-8362.
30. 2+ influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels. Biophys J 70, 2165-2174.
31. Schneggenburger R, Zhou Z, Konnerth A & Neher E (1993). Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron 11, 133-143.
32. Tomasetti M, Graciotti L, Fulgenzi G & Granata AL (2001). Determination of high-energy phosphate compounds and inorganic phosphate by reversed-phase high-performance liquid chromatography: Evaluation of myocardial metabolic status in aerobically perfused and hypoxic mouse heart. J Chromatogr B Biomed Sci Appl 751, 229-236.
33. 3 receptor channels in rat hippocampal interneurons. J Neurophysiol 89, 1864-1869.
34. Veech RL, Guynn R & Veloso D (1972). The time-course of the effects of ethanol on the redox and phosphorylation states of rat liver. Biochem J 127, 387-397.
35. Yakel JL, Lagrutta A, Adelman JP & North RA (1993). Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 90, 5030-5033.