-
1
-
-
0036183630
-
The mechanisms of action of PPARs
-
Berger J Moller DE The mechanisms of action of PPARs Annu Rev Med 2002 53 409 35
-
(2002)
Annu Rev Med
, vol.53
, pp. 409-435
-
-
Berger, J.1
Moller, D.E.2
-
2
-
-
0037376448
-
Dual PPARalpha/gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats
-
Brand CL Sturis J Gotfredsen CF Fleckner J Fledelius C Hansen BF Andersen B Ye JM Sauerberg P Wassermann K Dual PPARalpha/gamma activation provides enhanced improvement of insulin sensitivity and glycemic control in ZDF rats Am J Physiol Endocrinol Metab 2003 284 E841 54
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
, pp. E841-E854
-
-
Brand, C.L.1
Sturis, J.2
Gotfredsen, C.F.3
Fleckner, J.4
Fledelius, C.5
Hansen, B.F.6
Andersen, B.7
Ye, J.M.8
Sauerberg, P.9
Wassermann, K.10
-
4
-
-
24944463432
-
Effects of PPARgamma and combined agonists on the urinary tract of rats and other species
-
Cohen SM Effects of PPARgamma and combined agonists on the urinary tract of rats and other species Toxicol Sci 2005 87 322 27
-
(2005)
Toxicol Sci
, vol.87
, pp. 322-327
-
-
Cohen, S.M.1
-
5
-
-
0033305213
-
Peroxisome proliferator-activated receptors: nuclear control of metabolism
-
Desvergne B Wahli W Peroxisome proliferator-activated receptors: nuclear control of metabolism Endocr Rev 1999 20 649 88
-
(1999)
Endocr Rev
, vol.20
, pp. 649-688
-
-
Desvergne, B.1
Wahli, W.2
-
6
-
-
33845789088
-
Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: evidence for urolithiasis as the inciting event in the mode of action
-
Dominick MA White MR Sanderson TP Van Vleet T Cohen SM Arnold LE Cano M Tannehill-Gregg S Moehlenkamp JD Waites CR Schilling BE Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: evidence for urolithiasis as the inciting event in the mode of action Toxicol Pathol 2006 34 903 20
-
(2006)
Toxicol Pathol
, vol.34
, pp. 903-920
-
-
Dominick, M.A.1
White, M.R.2
Sanderson, T.P.3
Van Vleet, T.4
Cohen, S.M.5
Arnold, L.E.6
Cano, M.7
Tannehill-Gregg, S.8
Moehlenkamp, J.D.9
Waites, C.R.10
Schilling, B.E.11
-
7
-
-
0026517010
-
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
-
Dreyer C Krey G Keller H Givel F Helftenbein G Wahli W Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors Cell 1992 68 879 87
-
(1992)
Cell
, vol.68
, pp. 879-887
-
-
Dreyer, C.1
Krey, G.2
Keller, H.3
Givel, F.4
Helftenbein, G.5
Wahli, W.6
-
8
-
-
26844499207
-
Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urothelium in vivo
-
Egerod FL Nielsen HS Iversen L Thorup I Storgaard T Oleksiewicz MB Biomarkers for early effects of carcinogenic dual-acting PPAR agonists in rat urinary bladder urothelium in vivo Biomarkers 2005 10 295 309
-
(2005)
Biomarkers
, vol.10
, pp. 295-309
-
-
Egerod, F.L.1
Nielsen, H.S.2
Iversen, L.3
Thorup, I.4
Storgaard, T.5
Oleksiewicz, M.B.6
-
10
-
-
32644460092
-
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions
-
Feige JN Gelman L Michalik L Desvergne B Wahli W From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions Prog Lipid Res 2006 45 120 59
-
(2006)
Prog Lipid Res
, vol.45
, pp. 120-159
-
-
Feige, J.N.1
Gelman, L.2
Michalik, L.3
Desvergne, B.4
Wahli, W.5
-
11
-
-
0031408955
-
Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans
-
Guan Y Zhang Y Davis L Breyer MD Expression of peroxisome proliferator-activated receptors in urinary tract of rabbits and humans Am J Physiol Renal Physiol 1997 273 F1013 22
-
(1997)
Am J Physiol Renal Physiol
, vol.273
, pp. F1013-F1022
-
-
Guan, Y.1
Zhang, Y.2
Davis, L.3
Breyer, M.D.4
-
12
-
-
0016799622
-
The mammalian urinary bladder: an accommodating organ
-
Hicks RM The mammalian urinary bladder: an accommodating organ Biol Rev Philos Soc 1975 50 215 46
-
(1975)
Biol Rev Philos Soc
, vol.50
, pp. 215-246
-
-
Hicks, R.M.1
-
13
-
-
0031830264
-
Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse
-
Jain S Pulikuri S Zhu Y Qi C Kanwar YS Yeldandi AV Rao MS Reddy JK Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse Am J Pathol 1998 153 349 54
-
(1998)
Am J Pathol
, vol.153
, pp. 349-354
-
-
Jain, S.1
Pulikuri, S.2
Zhu, Y.3
Qi, C.4
Kanwar, Y.S.5
Yeldandi, A.V.6
Rao, M.S.7
Reddy, J.K.8
-
14
-
-
0030771852
-
DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5’-flanking region
-
Juge-Aubry C Pernin A Favez T Burger AG Wahli W Meier CA Desvergne B DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5’-flanking region J Biol Chem 1997 272 25252 59
-
(1997)
J Biol Chem
, vol.272
, pp. 25252-25259
-
-
Juge-Aubry, C.1
Pernin, A.2
Favez, T.3
Burger, A.G.4
Wahli, W.5
Meier, C.A.6
Desvergne, B.7
-
16
-
-
0034713444
-
Roles of PPARs in health and disease
-
Kersten S Desvergne B Wahli W Roles of PPARs in health and disease Nature 2000 405 421 4
-
(2000)
Nature
, vol.405
, pp. 421-424
-
-
Kersten, S.1
Desvergne, B.2
Wahli, W.3
-
17
-
-
15744366162
-
Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity
-
Kim DJ Murray IA Burns AM Gonzalez FJ Perdew GH Peters JM Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity J Biol Chem 2005 280 9519 27
-
(2005)
J Biol Chem
, vol.280
, pp. 9519-9527
-
-
Kim, D.J.1
Murray, I.A.2
Burns, A.M.3
Gonzalez, F.J.4
Perdew, G.H.5
Peters, J.M.6
-
18
-
-
0041820128
-
Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis
-
Larsen PJ Jensen PB Sørensen RV Larsen LK Vrang N Wulff EM Wassermann K Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis Diabetes 2003 52 2249 59
-
(2003)
Diabetes
, vol.52
, pp. 2249-2259
-
-
Larsen, P.J.1
Jensen, P.B.2
Sørensen, R.V.3
Larsen, L.K.4
Vrang, N.5
Wulff, E.M.6
Wassermann, K.7
-
19
-
-
33745700036
-
Can thiazolidinediones delay disease progression in type 2 diabetes?
-
Leiter LA Can thiazolidinediones delay disease progression in type 2 diabetes? Curr Med Res Opin 2006 22 1193 201
-
(2006)
Curr Med Res Opin
, vol.22
, pp. 1193-1201
-
-
Leiter, L.A.1
-
20
-
-
0035797363
-
(-)3-[4-[2-(Phenoxazin-10-yl) ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity
-
Lohray BB Lohray VB Bajji AC Kalchar S Poondra RR Padakanti S Chakrabarti R Vikramadithyan RK Misra P Juluri S Mamidi NV Rajagopalan R (-)3-[4-[2-(Phenoxazin-10-yl) ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity J Med Chem 2001 44 2675 8
-
(2001)
J Med Chem
, vol.44
, pp. 2675-2678
-
-
Lohray, B.B.1
Lohray, V.B.2
Bajji, A.C.3
Kalchar, S.4
Poondra, R.R.5
Padakanti, S.6
Chakrabarti, R.7
Vikramadithyan, R.K.8
Misra, P.9
Juluri, S.10
Mamidi, N.V.11
Rajagopalan, R.12
-
22
-
-
33646180263
-
Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis
-
Morimura K Cheung C Ward JM Reddy JK Gonzalez FJ Differential susceptibility of mice humanized for peroxisome proliferator-activated receptor alpha to Wy-14,643-induced liver tumorigenesis Carcinogenesis 2006 27 1074 80
-
(2006)
Carcinogenesis
, vol.27
, pp. 1074-1080
-
-
Morimura, K.1
Cheung, C.2
Ward, J.M.3
Reddy, J.K.4
Gonzalez, F.J.5
-
23
-
-
33947114905
-
Urothelial progenitor cells: regional differences in the rat bladder
-
Nguyen MM Urothelial progenitor cells: regional differences in the rat bladder Cell Prolif 2007 40 157 65
-
(2007)
Cell Prolif
, vol.40
, pp. 157-165
-
-
Nguyen, M.M.1
-
24
-
-
26844565049
-
Generalized cellular hypertrophy is induced by a dual-acting PPAR agonist in rat urinary bladder urothelium in vivo
-
Oleksiewicz MB Thorup I Nielsen HS Andersen HV Hegelund AC Iversen L Guldberg TS Brinck PR Sjogren I Thinggaard UK Jørgensen L Jensen MB Generalized cellular hypertrophy is induced by a dual-acting PPAR agonist in rat urinary bladder urothelium in vivo Toxicol Pathol 2005 33 552 60
-
(2005)
Toxicol Pathol
, vol.33
, pp. 552-560
-
-
Oleksiewicz, M.B.1
Thorup, I.2
Nielsen, H.S.3
Andersen, H.V.4
Hegelund, A.C.5
Iversen, L.6
Guldberg, T.S.7
Brinck, P.R.8
Sjogren, I.9
Thinggaard, U.K.10
Jørgensen, L.11
Jensen, M.B.12
-
25
-
-
26044475136
-
Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand?
-
Peters JM Cheung C Gonzalez FJ Peroxisome proliferator-activated receptor-alpha and liver cancer: where do we stand? J Mol Med 2005 83 774 85
-
(2005)
J Mol Med
, vol.83
, pp. 774-785
-
-
Peters, J.M.1
Cheung, C.2
Gonzalez, F.J.3
-
26
-
-
14644427833
-
The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats
-
Pickavance LC Brand CL Wassermann K Wilding JP The dual PPARalpha/gamma agonist, ragaglitazar, improves insulin sensitivity and metabolic profile equally with pioglitazone in diabetic and dietary obese ZDF rats Br J Pharmacol 2005 144 308 16
-
(2005)
Br J Pharmacol
, vol.144
, pp. 308-316
-
-
Pickavance, L.C.1
Brand, C.L.2
Wassermann, K.3
Wilding, J.P.4
-
27
-
-
2542462552
-
Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects: a 12-week, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm
-
Saad MF Greco S Osei K Lewin AJ Edwards C Nunez M Reinhardt RR Ragaglitazar improves glycemic control and lipid profile in type 2 diabetic subjects: a 12-week, double-blind, placebo-controlled dose-ranging study with an open pioglitazone arm Diabetes 2004 27 1324 9
-
(2004)
Diabetes
, vol.27
, pp. 1324-1329
-
-
Saad, M.F.1
Greco, S.2
Osei, K.3
Lewin, A.J.4
Edwards, C.5
Nunez, M.6
Reinhardt, R.R.7
-
28
-
-
34250163202
-
PPARalpha regulates miRNA-mediated signaling cascade responsible for hepatocellular proliferation
-
10.1128/MCB.00317-07
-
Shah YM Morimura K Yang Q Tanabe T Takagi M Gonzalez FJ PPARalpha regulates miRNA-mediated signaling cascade responsible for hepatocellular proliferation Mol Cell Biol 2007 10.1128/MCB.00317-07
-
(2007)
Mol Cell Biol
-
-
Shah, Y.M.1
Morimura, K.2
Yang, Q.3
Tanabe, T.4
Takagi, M.5
Gonzalez, F.J.6
-
29
-
-
0028152842
-
Normal human urothelial cells in vitro: proliferation and induction of stratification
-
Southgate J Hutton KA Thomas DF Trejdosiewicz LK Normal human urothelial cells in vitro: proliferation and induction of stratification Lab Invest 1994 71 583 94
-
(1994)
Lab Invest
, vol.71
, pp. 583-594
-
-
Southgate, J.1
Hutton, K.A.2
Thomas, D.F.3
Trejdosiewicz, L.K.4
-
31
-
-
23644456172
-
Therapeutic roles of peroxisome proliferator-activated receptor agonists
-
Staels B Fruchart JC Therapeutic roles of peroxisome proliferator-activated receptor agonists Diabetes 2005 54 2460 70
-
(2005)
Diabetes
, vol.54
, pp. 2460-2470
-
-
Staels, B.1
Fruchart, J.C.2
-
32
-
-
32644478044
-
Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease
-
Stahlschmidt J Varley CL Toogood G Selby PJ Southgate J Urothelial differentiation in chronically urine-deprived bladders of patients with end-stage renal disease Kidnet Int 2005 68 1032 40
-
(2005)
Kidnet Int
, vol.68
, pp. 1032-1040
-
-
Stahlschmidt, J.1
Varley, C.L.2
Toogood, G.3
Selby, P.J.4
Southgate, J.5
-
33
-
-
34447547778
-
Rodent carcinogenicity profile of the antidiabetic dual PPAR {alpha} and {gamma} agonist muraglitazar
-
Tannehill-Gregg SH Sanderson TP Minnema D Voelker R Ulland B Cohen SM Arnold LL Schilling BE Waites CR Dominick MA Rodent carcinogenicity profile of the antidiabetic dual PPAR {alpha} and {gamma} agonist muraglitazar Toxicol Sci 2007 98 258 70
-
(2007)
Toxicol Sci
, vol.98
, pp. 258-270
-
-
Tannehill-Gregg, S.H.1
Sanderson, T.P.2
Minnema, D.3
Voelker, R.4
Ulland, B.5
Cohen, S.M.6
Arnold, L.L.7
Schilling, B.E.8
Waites, C.R.9
Dominick, M.A.10
-
36
-
-
2942572944
-
Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme
-
Varley CL Stahlschmidt J Lee WC Holder J Diggle C Selby PJ Trejdosiewicz LK Southgate J Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme J Cell Sci 2004 15 2029 36
-
(2004)
J Cell Sci
, vol.15
, pp. 2029-2036
-
-
Varley, C.L.1
Stahlschmidt, J.2
Lee, W.C.3
Holder, J.4
Diggle, C.5
Selby, P.J.6
Trejdosiewicz, L.K.7
Southgate, J.8
-
37
-
-
1942437006
-
Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells
-
Varley CL Stahlschmidt J Smith B Stower M Southgate J Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells Am J Pathol 2004 164 1789 98
-
(2004)
Am J Pathol
, vol.164
, pp. 1789-1798
-
-
Varley, C.L.1
Stahlschmidt, J.2
Smith, B.3
Stower, M.4
Southgate, J.5
-
39
-
-
0037362638
-
PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly
-
Ye JM Iglesias MA Watson DG Ellis B Wood L Jensen PB Sørensen RV Larsen PJ Cooney GJ Wassermann K Kraegen EW PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly Am J Physiol Endocrinol Metab 2003 284 E531 40
-
(2003)
Am J Physiol Endocrinol Metab
, vol.284
, pp. E531-E540
-
-
Ye, J.M.1
Iglesias, M.A.2
Watson, D.G.3
Ellis, B.4
Wood, L.5
Jensen, P.B.6
Sørensen, R.V.7
Larsen, P.J.8
Cooney, G.J.9
Wassermann, K.10
Kraegen, E.W.11
-
40
-
-
33645868661
-
Peroxisome proliferator-activated receptor alpha and gamma ligands differentially affect smooth muscle cell proliferation and migration
-
Zahradka P Wright B Fuerst M Yurkova N Molnar K Taylor CG Peroxisome proliferator-activated receptor alpha and gamma ligands differentially affect smooth muscle cell proliferation and migration J Pharmacol Exp Ther 2006 317 651 9
-
(2006)
J Pharmacol Exp Ther
, vol.317
, pp. 651-659
-
-
Zahradka, P.1
Wright, B.2
Fuerst, M.3
Yurkova, N.4
Molnar, K.5
Taylor, C.G.6
-
41
-
-
0038078864
-
Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation
-
Zahradka P Yurkova N Litchie B Moon MC Del Rizzo DF Taylor CG Activation of peroxisome proliferator-activated receptors alpha and gamma1 inhibits human smooth muscle cell proliferation Mol Cell Biochem 2003 246 105 10
-
(2003)
Mol Cell Biochem
, vol.246
, pp. 105-110
-
-
Zahradka, P.1
Yurkova, N.2
Litchie, B.3
Moon, M.C.4
Del Rizzo, D.F.5
Taylor, C.G.6
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