Localization of hRad9 in breast cancer

BMC Cancer

Volumn 8, Issue , 2008, Pages

  Chan, Vivian ^a   Khoo, U S ^b   Wong, M S ^a   Lau, Ken ^a   Suen, Dacita ^a   Li, George ^a   Kwong, Ava ^a   Chan, T K ^a  

^a QUEEN MARY HOSPITAL   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; NUCLEAR PROTEIN; PHOSPHATASE; PROTEIN RAD1; PROTEIN RAD9; CELL CYCLE PROTEIN; ISOPROTEIN; PHOSPHOTRANSFERASE; TRANSCRIPTION FACTOR;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER CELL CULTURE; CANCER GROWTH; CELL NUCLEUS; CLINICAL ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENETIC STABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; PROTEIN DEPHOSPHORYLATION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; ANTIBODY SPECIFICITY; BIOSYNTHESIS; BREAST TUMOR; CARCINOMA; CELL TRANSFORMATION; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; MAMMARY GLAND; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TRANSCRIPTION INITIATION;

BREAST NEOPLASMS; CARCINOMA; CELL CYCLE PROTEINS; CELL TRANSFORMATION, NEOPLASTIC; DNA REPAIR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MAMMARY GLANDS, HUMAN; ORGAN SPECIFICITY; PHOSPHORYLATION; PHOSPHOTRANSFERASES; PROTEIN ISOFORMS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 48449093045     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-8-196     Document Type: Article

References (15)

1. Lieberman HB Hopkins KM Nass M Demetrick D Darvey S A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene Proc Natl Acad Sci USA 1996, 93:13890-13895 19459 8943031 10.1073/pnas.93.24.13890
2. Wang L Hsu C-L Ni J Wang P-H Yeh S Keng P Chang C Human checkpoint protein hRad9 functions as a negative coregulator to repress androgen receptor transactivation in prostate cancer cells Mol Cell Biol 2004, 24:2202-2213 350564 14966297 10.1128/MCB.24.5.2202-2213.2004
3. Hopkins KM Wang X Berlin A Hang H Thaker HM Lieberman HB Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue Cancer Res 2003, 63:5291-5298 14500360
4. Paulovich AG Toczyski DP Hartwell LH When checkpoints fail Cell 1997, 88:315-321 10.1016/S0092-8674(00)81870-X 9039258
5. Hartwell LH Kastan MB Cell cycle control and cancer Science 1994, 266:1821-1828 10.1126/science.7997877 7997877
6. Maniwa Y Yoshimura M Bermudez VP Yuki T Okada K Kanomata N Ohbayashi C Hayashi Y Hurwitz J Okita Y Accumulation of hRad9 protein in the nuclei of nonsmall cell lung carcinoma cells Cancer 2005, 103:126-132 10.1002/ cncr.20740 15558813
7. Maniwa Y Yoshimura M Bermudez VP Okada K Kanomata N Ohbayashi C Nishimura Y Hayashi Y Hurwitz J Okita Y His239Arg SNP of HRAD9 is associated with lung adenocarcinoma Cancer 2006, 106:1117-1122 10.1002/ cncr.21705 16444745
8. Cheng CK Chow LW Loo WT Chan TK Chan V The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer Cancer Res 2005, 65:8646-8654 10.1158/ 0008-5472.CAN-04-4243 16204032
9. Volkmer E Karnitz LM Human homologs of Schizosaccharomyces pombe rad1, hus1, and rad9 form a DNA damage-responsive protein complex J Biol Chem 1999, 274:567-570 10.1074/jbc.274.2.567 9872989
10. St Onge RP Besley BDA Pelley JL Davey S A role for the phosphorylation of hRad9 in checkpoint signaling J Biol Chem 2003, 278:26620-26628 10.1074/jbc.M303134200 12734188
11. Hirari I Wang HG A role of the C-terminal region of human Rad9 (hRad9) in nuclear transport of the hRad9 checkpoint complex J Biol Chem 2002, 277:25722-25727 10.1074/jbc.M203079200 11994305
12. Kaur R Kostrub CF Enoch T Structure-function analysis of fission yeast Hus1-Rad1-Rad9 checkpoint complex Mol Biol Cell 2001, 12:3744-3758 60752 11739777
13. Komatsu K Miyashita T Hang H Hopkins KM Zheng W Cuddeback S Yamada M Lieberman HB Wang HG Human homologue of S pombe Rad9 interacts with Bcl-2/Bcl-xL and promotes apoptosis Nat Cell Biol 2000, 2:1-6 10.1038/ 71316 10620799
14. Iggo R Gatter K Bartek J Lane D Harris AL Increased expression of mutant forms of p53 oncogene in primary lung cancer Lancet 1990, 335:675-679 10.1016/0140-6736(90)90801-B 1969059
15. Lindsey-Boltz LA Bermudez VP Hurwitz J Sancar A Purification and characterization of human DNA damage checkpoint Rad complexes Proc Natl Acad Sci U S A 2001, 98:11236-11241 58713 11572977 10.1073/pnas.201373498