Evidence against PALB2 involvement in Icelandic breast cancer susceptibility

Journal of Negative Results in BioMedicine

Volumn 7, Issue 1, 2008, Pages

  Gunnarsson, Haukur ^a   Arason, Adalgeir ^a   Gillanders, Elizabeth M ^b   Agnarsson, Bjarni A ^a   Johannesdottir, Gudrun ^a   Johannsson, Oskar Th ^a   Barkardottir, Rosa B ^a  

^a LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; CANCER RISK; CANCER SCREENING; CANCER SUSCEPTIBILITY; FEMALE; GENE MUTATION; GENE TARGETING; GENETIC LINKAGE; GEOGRAPHY; HUMAN; HUMAN TISSUE; ICELAND; MAJOR CLINICAL STUDY; ONCOGENE; PALB2 GENE; TUMOR GENE; ADULT; AGED; BREAST TUMOR; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; REPRODUCIBILITY;

NUCLEAR PROTEIN; PALB2 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ICELAND; MIDDLE AGED; NUCLEAR PROTEINS; REPRODUCIBILITY OF RESULTS; TUMOR SUPPRESSOR PROTEINS;

EID: 48449091498     PISSN: None     EISSN: 14775751     Source Type: Journal    
DOI: 10.1186/1477-5751-7-5     Document Type: Article

References (22)

1. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. JD Fackenthal OI Olopade, Nat Rev Cancer Nature Publishing Group 2007 7 12 937 948 10.1038/nrc2054 18034184
2. The emerging landscape of breast cancer susceptibility. MR Stratton N Rahman, Nat Genet 2008 40 1 17 22 10.1038/ng.2007.53 18163131
3. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. S Reid D Schindler H Hanenberg K Barker S Hanks R Kalb K Neveling P Kelly S Seal M Freund M Wurm SD Batish FP Lach S Yetgin H Neitzel H Ariffin M Tischkowitz CG Mathew AD Auerbach N Rahman, Nat Genet 2007 39 2 162 164 10.1038/ng1947 17200671
4. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. B Xia JC Dorsman N Ameziane Y de Vries MA Rooimans Q Sheng G Pals A Errami E Gluckman J Llera W Wang DM Livingston H Joenje JP de Winter, Nat Genet 2007 39 2 159 161 10.1038/ng1942 17200672
5. Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. B Xia Q Sheng K Nakanishi A Ohashi J Wu N Christ X Liu M Jasin FJ Couch DM Livingston, Mol Cell 2006 22 6 719 729 10.1016/j.molcel.2006.05.022 16793542
6. A recurrent mutation in PALB2 in Finnish cancer families. H Erkko B Xia J Nikkila J Schleutker K Syrjakoski A Mannermaa A Kallioniemi K Pylkas SM Karppinen K Rapakko A Miron Q Sheng G Li H Mattila DW Bell DA Haber M Grip M Reiman A Jukkola-Vuorinen A Mustonen J Kere LA Aaltonen VM Kosma V Kataja Y Soini RI Drapkin DM Livingston R Winqvist, Nature 2007 446 7133 316 319 10.1038/nature05609 17287723
7. Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women. WD Foulkes P Ghadirian MR Akbari N Hamel S Giroux N Sabbaghian A Darnel R Royer A Poll E Fafard A Robidoux G Martin TA Bismar M Tischkowitz F Rousseau SA Narod, Breast Cancer Res 2007 9 R83 18053174 10.1186/bcr1828
8. PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene. N Rahman S Seal D Thompson P Kelly A Renwick A Elliott S Reid K Spanova R Barfoot T Chagtai H Jayatilake L McGuffog S Hanks DG Evans D Eccles DF Easton MR Stratton, Nat Genet 2007 39 2 165 167 10.1038/ng1959 17200668
9. Analysis of PALB2/FANCN-associated breast cancer families. M Tischkowitz B Xia N Sabbaghian JS Reis-Filho N Hamel G Li EH van Beers L Li T Khalil LA Quenneville A Omeroglu A Poll P Lepage N Wong PM Nederlof A Ashworth PN Tonin SA Narod DM Livingston WD Foulkes, Proc Natl Acad Sci U S A 2007 104 16 6788 6793 10.1073/pnas.0701724104 17420451
10. A population study of mutations and LOH at breast cancer gene loci in tumours from sister pairs: two recurrent mutations seem to account for all BRCA1/BRCA2 linked breast cancer in Iceland. A Arason A Jonasdottir RB Barkardottir JT Bergthorsson MD Teare DF Easton V Egilsson, J Med Genet 1998 35 6 446 449 9643283
11. High prevalence of the 999del5 mutation in icelandic breast and ovarian cancer patients. G Johannesdottir J Gudmundsson JT Bergthorsson A Arason BA Agnarsson G Eiriksdottir OT Johannsson A Borg S Ingvarsson DF Easton V Egilsson RB Barkardottir, Cancer Res 1996 56 16 3663 3665 8706004
12. Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland. L Sarantaus P Huusko H Eerola V Launonen P Vehmanen K Rapakko E Gillanders K Syrjakoski T Kainu P Vahteristo R Krahe K Paakkonen J Hartikainen C Blomqvist T Lopponen K Holli M Ryynanen R Butzow A Borg B Wasteson Arver E Holmberg A Mannermaa J Kere OP Kallioniemi R Winqvist H Nevanlinna, Eur J Hum Genet 2000 8 10 757 763 10.1038/sj.ejhg.5200529 11039575
13. Haplotype analysis in Icelandic and Finnish BRCA2 999del5 breast cancer families. RB Barkardottir L Sarantaus A Arason P Vehmanen PO Bendahl T Kainu K Syrjakoski R Krahe P Huusko S Pyrhonen K Holli OP Kallioniemi V Egilsson J Kere H Nevanlinna, Eur J Hum Genet 2001 9 10 773 779 10.1038/sj.ejhg.5200717 11781689
14. Identification of a novel splice-site mutation of the BRCA1 gene in two breast cancer families: screening reveals low frequency in Icelandic breast cancer patients. JT Bergthorsson A Jonasdottir G Johannesdottir A Arason V Egilsson S Gayther A Borg S Hakanson S Ingvarsson RB Barkardottir, Hum Mutat 1998 Suppl 1 S195 7 9452084
15. mtDNA and the Islands of the North Atlantic: Estimating the Proportions of Norse and Gaelic Ancestry. A Helgason E Hickey S Goodacre V Bosnes K Stefánsson R Ward B Sykes, Am J Hum Genet 2001 68 3 723 737 10.1086/318785 11179019
16. Estimating Scandinavian and Gaelic Ancestry in the Male Settlers of Iceland. A Helgason S Sigurardóttir J Nicholson B Sykes EW Hill DG Bradley V Bosnes JR Gulcher R Ward K Stefánsson, The American Journal of Human Genetics 2000 67 3 697 717 10.1086/303046 10931763
17. A simple salting out procedure for extracting DNA from human nucleated cells. SA Miller DD Dykes HF Polesky, Nucleic Acids Res 1988 16 3 1215 10.1093/nar/16.3.1215 3344216
18. Distinct genomic profiles in hereditary breast tumors identified by array-based comparative genomic hybridization. G Jönsson TL Naylor J Vallon-Christersson J Staaf J Huang MR Ward JD Greshock L Luts H Olsson N Rahman M Stratton M Ringner A Borg BL Weber, Cancer Res 2005 65 17 7612 7621 16140926
19. University of California Santa Cruz (UCSC) Genome Browser Website. http://genome.ucsc.edu/
20. David Duffy's QIMR Homepage. http://www.qimr.edu.au/davidD/
21. Genetic analysis of breast cancer in the cancer and steroid hormone study. EB Claus N Risch WD Thompson, Am J Hum Genet 1991 48 232 242 1990835
22. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium. DF Easton DT Bishop D Ford GP Crockford, Am J Hum Genet 1993 52 4 678 701 8460634