Immunogenicity of a recombinant malaria vaccine candidate, domain I + II of AMA-1 ectodomain, from Indian P. falciparum alleles

Vaccine

Volumn 26, Issue 35, 2008, Pages 4526-4535

  Lalitha, P V ^a   Biswas, S ^b   Pillai, C R ^b   Saxena, R K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF MALARIA RESEARCH   (India)

Author keywords

Apical membrane antigen; Domain I + II; Growth inhibition assay; Malaria; Recombinant protein; Vaccine

Indexed keywords

ANTISERUM; APICAL MEMBRANE ANTIGEN 1; CYTOKINE; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; MALARIA VACCINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 4G2.DC1; POLYCLONAL ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE EXPRESSION; HAPLOTYPE; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOLECULAR CLONING; MOUSE; NONHUMAN; PARASITE ISOLATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; RABBIT; SPLEEN CELL; SUPERNATANT;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, PROTOZOAN; ANTIBODY SPECIFICITY; ANTIGENS, PROTOZOAN; CELL PROLIFERATION; CYTOKINES; DNA, PROTOZOAN; HAPLOTYPES; HUMANS; IMMUNOGLOBULIN G; INDIA; LYMPHOCYTES; MALARIA VACCINES; MALARIA, FALCIPARUM; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RABBITS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SPLEEN; VACCINES, SYNTHETIC;

EID: 48449088851     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.06.031     Document Type: Article

References (48)

1. World Health Organisation. Malaria incidence estimates at country level for the year 2004: proposed estimates and draft report. Roll Back Malaria: World Health Organisation; 2004.
2. Good M.F., Kaslow D.C., and Miller L.H. Pathways and strategies for developing a malaria blood-stage vaccine. Annu Rev Immunol 16 (1998) 57-87
3. Brown G.V., Anders R.F., Mitchell G.F., and Heywood P.F. Target antigens of purified human immunoglobulins which inhibit growth of Plasmodium falciparum in vitro. Nature 297 (1982) 591-593
4. Sabchareon A., Burnouf T., Ouattara D., Attanath P., Bouharoun-Tayoun H., Chantavanich P., et al. Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am J Trop Med Hyg 45 (1991) 297-308
5. Miller L.H., Baruch D.I., Marsh K., and Doumbo O.K. The pathogenic basis of malaria. Nature 415 (2002) 673-679
6. Dutta S., Lalitha P.V., Ware L.A., Barbosa A., Moch J.K., Vassell M.A., et al. Purification, characterization, and immunogenicity of the refolded ectodomain of the Plasmodium falciparum apical membrane antigen 1 expressed in Escherichia coli. Infect Immun 70 (2002) 3101-3110
7. Kocken C.H., Withers-Martinez C., Dubbeld M.A., Van Der Wel A., Hackett F., Blackman M.J., et al. High-level expression of the malaria blood-stage vaccine candidate Plasmodium falciparum apical membrane antigen 1 and induction of antibodies that inhibit erythrocyte invasion. Infect Immun 70 (2002) 4471-4476
8. Stowers A.W., Kennedy M.C., Keegan B.P., Saul A., Long C.A., and Miller L.H. Vaccination of monkeys with recombinant Plasmodium falciparum apical membrane antigen 1 confers protection against blood-stage malaria. Infect Immun 70 (2002) 6961-6967
9. Thomas A.W., Deans J.A., Mitchell G.H., Alderson T., and Cohen S. The Fab fragments of monoclonal IgG to a merozoite surface antigen inhibit Plasmodium knowlesi invasion of erythrocytes. Mol Biochem Parasitol 13 (1984) 187-199
10. Bodescot M., Silvie O., Siau A., Refour P., Pino P., Franetich J.F., et al. Transcription status of vaccine candidate genes of Plasmodium falciparum during the hepatic phase of its life cycle. Parasitol Res 92 (2004) 449-452
11. Krzych U., Lyon J.A., Jareed T., Schneider I., Hollingdale M.R., Gordon D.M., et al. T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens. J Immunol 155 (1995) 4072-4077
12. Peterson M.G., Marshall V.M., Smythe J.A., Crewther P.E., Lew A., Silva A., et al. Integral membrane protein located in the apical complex of Plasmodium falciparum. Mol Cell Biol 9 (1989) 3151-3154
13. Silvie O., Franetich J.F., Charrin S., Mueller M.S., Siau A., Bodescot M., et al. A role for apical membrane antigen 1 during invasion of hepatocytes by Plasmodium falciparum sporozoites. J Biol Chem 279 (2004) 9490-9496
14. Howell S.A., Hackett F., Jongco A.M., Withers-Martinez C., Kim K., Carruthers V.B., et al. Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens. Mol Microbiol 57 (2005) 1342-1356
15. Howell S.A., Withers-Martinez C., Kocken C.H., Thomas A.W., and Blackman M.J. Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1. J Biol Chem 276 (2001) 31311-31320
16. Narum D.L., and Thomas A.W. Differential localization of full length and processed form of PF83/AMA-1, an apical membrane antigen of Plasmodium falciparum merozoites. Mol Biochem Parasitol 67 (1994) 59-68
17. Hodder A.N., Crewther P.E., Matthew M.L., Reid G.E., Moritz R.L., Simpson R.J., et al. The disulfide bond structure of Plasmodium apical membrane antigen-1. J Biol Chem 271 (1996) 29446-29452
18. Triglia T.J., Healer S., Caruana R., Hodder A.N., Anders R.F., Crabb B.S., et al. Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species. Mol Microbiol 38 (2000) 706-718
19. Coley A.M., Parisi K., Masciantonio R., Hoeck J., Casey J.L., Murphy V.J., et al. The most polymorphic residue on Plasmodium falciparum apical membrane antigen 1 determines binding of an invasion-inhibitory antibody. Infect Immun 74 (2006) 2628-2636
20. Kocken C.H., van der Wel A.M., Dubbeld M.A., Narum D.L., Van de Rijke F.M., van Gemert G.J., et al. Precise timing of expression of a Plasmodium falciparum-derived transgene in Plasmodium berghei is a critical determinant of subsequent subcellular localization. J Biol Chem 273 (1998) 15119-15124
21. Mueller M.S., Renard A., Boat F., Vogel D., Naegeli M., Zurbriggen R., et al. Induction of parasite growth-inhibitory antibodies by a virosomal formulation of a peptidomimetic of loop I from domain III of Plasmodium falciparum apical membrane antigen 1. Infect Immun 71 (2003) 4749-4758
22. Dutta S., Lee S.Y., Batchelor A.H., and Lanar D.E. Structural basis of antigenic escape of a malaria vaccine candidate. Proc Natl Acad Sci USA 104 (2007) 12488-12493
23. Polley S.D., Mwangi T., Kocken C.H., Thomas A.W., Dutta S., Lanar D.E., et al. Human antibodies to recombinant protein constructs of Plasmodium falciparum apical membrane antigen 1 (AMA1) and their associations with protection from malaria. Vaccine 23 (2004) 718-728
24. Anders R.F., Crewther P.E., Edwards S., Margetts M., Matthew M.L., Pollock B., et al. Immunization with recombinant AMA-1 protect mice against infection with Plasmodium chabaudi. Vaccine 16 (1998) 240-247
25. Collins W.E., Pye D., Crewther P.E., Vandenberg K.L., Galland G.G., Sulzer A.J., et al. Protective immunity induced in squirrel monkeys with recombinant apical membrane antigen-1 of Plasmodium fragile. Am J Trop Med Hyg 51 (1994) 711-719
26. Narum D.L., Ogun S.A., Thomas A.W., and Holder A.A. Immunization with parasite-derived apical membrane antigen 1 or passive immunization with a specific monoclonal antibody protects BALB/c mice against lethal Plasmodium yoelii yoelii YM blood-stage infection. Infect Immun 68 (2000) 2899-2906
27. Dutta S., Haynes J.D., Moch J.K., Barbosa A., and Lanar D.E. Invasion-inhibitory antibodies inhibit proteolytic processing of apical membrane antigen-1 of Plasmodium falciparum merozoites. Proc Natl Acad Sci USA 100 (2003) 12295-12300
28. Hodder A.N., Crewther P.E., and Anders R.F. Specificity of the protective antibody response to apical membrane antigen 1. Infect Immun 69 (2001) 3286-3294
29. Nair M., Hinds M.G., Coley A.M., Hodder A.N., Foley M., Anders R., et al. Structure of Domain III of the Blood-stage malaria vaccine candidate, Plasmodium falciparum apical membrane antigen 1 (AMA1). J Mol Biol 322 (2002) 741
30. Malkin E.M., Diemert D.J., McArthur J.H., Perreault J.R., Miles A.P., Giersing B.K., et al. Phase 1 clinical trial of apical membrane antigen 1: an asexual blood-stage vaccine for Plasmodium falciparum malaria. Infect Immun 73 (2005) 3677-3685
31. Polhemus M.E., Magill A.J., Cummings J.F., Kester K.E., Ockenhouse C.F., Lanar D.E., et al. Phase I dose escalation safety and immunogenicity trial of Plasmodium falciparum apical membrane protein (AMA-1) FMP2.1, adjuvanted with AS02A, in malaria-naive adults at the Walter Reed Army Institute of Research. Vaccine 25 (2007) 4203-4212
32. Lalitha P.V., Ware L.A., Barbosa A., Dutta S., Moch J.K., Haynes J.D., et al. Production of the subdomains of the Plasmodium falciparum apical membrane antigen 1 ectodomain and analysis of the immune response. Infect Immun 72 (2004) 4464-4470
33. Healer J., Triglia T., Hodder A.N., Gemmill A.W., and Cowman A.F. Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains. Infect Immun 73 (2005) 2444-2451
34. Anders R.F., McColl D.J., and Coppel R.L. Molecular variation in Plasmodium falciparum: polymorphic antigens of asexual erythrocytic stages. Acta Trop 53 (1993) 239-253
35. Escalante A.A., Lal A.A., and Ayala F.J. Genetic polymorphism and natural selection in the malaria parasite Plasmodium falciparum. Genetics 149 (1998) 189-202
36. Marshall V.M., Zhang L., Anders R.F., and Coppel R.L. Diversity of the vaccine candidate AMA-1 of Plasmodium falciparum. Mol Biochem Parasitol 77 (1996) 109-113
37. Cortes A., Mellombo M., Masciantonio R., Murphy V.J., Reeder J.C., and Anders R.F. Allele specificity of naturally acquired antibody responses against Plasmodium falciparum apical membrane antigen 1. Infect Immun 73 (2005) 422-430
38. Polley S.D., Chokejindachai W., and Conway D.J. Allele frequency based analysis robustly map sequence sites under balancing selection in a malaria vaccine candidate antigen. Genetics 165 (2003) 555-561
39. Healer J., Murphy V., Hodder A.N., Masciantonio R., Gemmill A.W., Anders R.F., et al. Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum. Mol Microbiol 52 (2004) 159-168
40. Kennedy M.C., Wang J., Zhang Y., Miles A.P., Chitsaz F., Saul A., et al. In vitro studies with recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1): production and activity of an AMA1 vaccine and generation of a multiallelic response. Infect Immun 70 (2002) 6948-6960
41. Biswas S., and Sharma Y.D. Lack of correlation exists between parasite growth inhibition and anti-HSP70 antibody levels in malaria patients' sera. Int J Parasitol 21 (1991) 213-217
42. Trager W., and Jensen J.B. Human malaria parasites in continuous culture. Science 193 (1976) 673-675
43. Burns J.M., Dunn P.D., and Russo D.M. Protective immunity against Plasmodium yoelii malaria induced by immunization with particulate blood-stage antigens. Infect Immun 65 (1997) 3138-3145
44. Patterson P.S., Bosshardt S.C., Udhayukumar V., Xiao L., Kidd M., Hunter R.L., et al. Prolonged expression of IFN-gamma induced by protective blood-stage immunization against Plasmodium yoelii malaria. Vaccine 18 (1999) 173-180
45. Udhayakumar V., Kariuki S., Kolczack M., Girma M., Roberts J.M., Oloo A.J., et al. Longitudinal study of natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in a holoendemic region of malaria in western Kenya: Asembo Bay Cohort Project VIII. Am J Trop Med Hyg 65 (2001) 100-107
46. Escalante A.A., Grebert H.M., Chaiyaroj S.C., Magris M., Biswas S., Nahlen B.L., et al. Polymorphism in the gene encoding the apical membrane antigen-1 (AMA-1) of Plasmodium falciparum. X. Asembo Bay Cohort Project. Mol Biochem Parasitol 113 (2001) 279-287
47. Lal A.A., Hughes M.A., Oliveira D.A., Nelson C., Bloland P.B., Oloo A.J., et al. Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria. Infect Immun 64 (1996) 1054-1059
48. Cortés A., Mellombo M., Mueller I., Benet A., Reeder J.C., and Anders R.F. Geographical structure of diversity and differences between symptomatic and asymptomatic infections for Plasmodium falciparum vaccine candidate AMA1. Infect Immun 71 (2003) 1416-1426