Phenotypic and genetic analyses of subcongenic BB.SHR rat lines shorten the region on chromosome 4 bearing gene(s) for underlying facets of metabolic syndrome

Physiological Genomics

Volumn 18, Issue , 2004, Pages 325-330

  Klöting, Nora ^a   Wilke, Barbara ^a   Klöting, Ingrid ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Congenic mapping; Dyslipidemia; Obesity; Rat model

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INITIATION FACTOR 2; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BLOOD; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 4; CONGENIC STRAIN; CONTROLLED STUDY; DYSLIPIDEMIA; GENE EXPRESSION; GENE MAPPING; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; INSULIN BLOOD LEVEL; LIVER; MALE; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROGENY; RAT; RAT STRAIN; RATING SCALE; SPONTANEOUSLY HYPERTENSIVE RAT; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

ANIMALS; ANIMALS, CONGENIC; CHROMOSOME MAPPING; CHROMOSOMES; HYPERINSULINISM; HYPERLIPIDEMIAS; MALE; OBESITY; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED SHR; SYNDROME;

ANIMALIA; EUKARYOTA;

EID: 4844231853     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00047.2004     Document Type: Article

References (26)

1. Al-Gazali LI, Makai S, Azzam A, and Hall CM. Wolcott-Rallison syndrome. Clin Dysmorphol 4: 227-233, 1995.
2. Biason-Lauber A, Lang-Muritano M, Vaccaro T, and Schoenle EJ. Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene. Diabetes 51: 2301-2305, 2002.
3. Brickwood S, Bonthron D, Al-Gazali LI, Piper K, Hearn T, Wilson DI, and Hanley NA. Wolcott-Rallison syndrome: pathogenetic insights into neonatal diabetes from new mutation and expression studies of Eif2ak3. J Med Genet 40: 685-689, 2003.
4. Castelnau P, Le Merrer M, Diatloff-Zito C, Marquis E, Tete MJ, and Robert JJ. Wolcott-Rallison syndrome: a case with endocrine and exocrine pancreatic deficiency and pancreatic hypertrophy. Eur J Pediatr 159: 631-633, 2000.
5. Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM, and Julier C. EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet 25: 406-409, 2000.
6. Dominiczak AF, Clark JS, Jeffs B, Anderson NH, Negrin CD, Lee WK, and Brosnan MJ. Genetics of experimental hypertension. J Hypertens 16: 1859-1869, 1998.
7. Galli J, Fakhrai-Rad H, Kamel A, Marcus X, Norgren S, and Luthman H. Pathophysiology and genetic characterization of the major diabetes locus in GK rats. Diabetes 48: 2463-2470, 1999.
8. GenBank. Rattus norvegicus chromosome 4 WGS supercontig. Accession number NW_047693 [Online]. http://www.ncbi.nlm.nih.gov/Genbank/GenbankSearch.html
9. Handing HP, Zeng HQ, Zhang YH, Jungries R, Chung P, Plesken H, Sabatini DD, and Ron D. Diabetes mellitus and exocrine pancreatic dysfunction in Perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell 7: 1153-1163, 2001.
10. Klimes I, Weston K, Kovacs P, Gasperikova D, Jezova D, Kvetnansky R, Thompson JR, Sebokova E, and Samani NJ. Mapping of genetic loci predisposing to hypertriglyceridemia in the hereditary hypertriglyceridemic rat: analysis of genetic association with related traits of the insulin resistance syndrome. Diabetologia 46: 352-358, 2003.
11. Klöting I and Vogt L. BB/O(ttawa)K(arlsburg) rats: features of a subline of diabetes-prone BB rats. Diabetes Res 18: 79-87, 1991.
12. Klöting I, Berg S, Kovacs P, Voigt B, Vogt L, and Schmidt S. Diabetes and hypertension in rodent models. Ann NY Acad Sci 827: 64-85, 1997.
13. Klöting I, Kovacs P, and Kuttler B. Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat. Biochem Biophys Res Commun 239: 106-110, 1997.
14. Klöting I, Kovacs P, and van den Brandt J. Congenic BB.SHR (D4Mit6-Npy-Spr) rats: a new aid to dissect the genetics of obesity. Obes Res 10: 1074-1077. 2002.
15. Klöting I, Kovacs P, and van den Brandt J. Quantitative trait loci for body weight, blood pressure, blood glucose and serum lipids: linkage analysis with wild rats (Kattus norvegicus). Biochem Biophys Res Commun 284: 1126-1133, 2001.
16. Klöting I, Kovacs P, and van den Brandt J. Sex-specific and sex-independent quantitative trait loci for facets of the metabolic syndrome in WOKW rats. Biochem Biophys Res Commun 284: 150-156, 2001.
17. Kovacs P and Klöting I. Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat. Arch Biochem Biophys 354: 139-143, 1998.
18. Kovacs P, van den Brandt J, and Klöting I. Genetic dissection of the syndrome X in the rat. Biochem Biophys Res Commun 269: 600-605, 2000.
19. Kovacs P, van den Brandt J, Bonné ACM, van Zutphen LFM, van Lith HA, and Klöting I. Congenic BB.SHR rat provided evidence for effects of a chromosome 4-segment (D4Mit6-Npy ∼1 cM) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet. Metabolism 50: 458-462, 2001.
20. Pravenec M and Kurtz TW. Genetics of Cd36 and the hypertension metabolic syndrome. Semin Nephrol 22: 148-153, 2002.
21. Pravenece M, Zidek V, Landa V, Kostka V, Musilova A, Kasdova A, Krenova D, Bila V, and Kren V. Genetic analysis of cardiovascular risk factor clustering in spontaneous hypertension. Folia Biol (Praha) 46: 233-240, 2000.
22. Stöss H, Pesch HJ, Pontz B, Otten A, and Spranger J. Wolcott-Rallison syndrome: diabetes mellitus and spondyloepiphyseal dysplasia. Eur J Pediatr 138: 120-129, 1982.
23. von Muhlendahl KE and Herkenhoff H. Long-term course of neonatal diabetes. N Engl J Med 333: 704-708, 1995.
24. Wolcott CD and Rallison ML. Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia. J Pediatr 80: 292-297, 1972.
25. Zhang P, McNaughton K, Li S, McGrath B, Reinert J, Liang SH, Yuan X, Ma K, and Caverner D. Perk eIF2 α kinase is required for multiple pancreatic functions and viability of secretory cells. Abstracts 4th West Coast Meeting on mRNA Stability and Translation, Seattle. WA 2001, p25.
26. Zhang PC, McGrath B, Li SA, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McBaughton K, and Cavener DR. The PERK eukaryotic initiation factor 2 α kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22: 3864-3874, 2002.