Elaboration of the oxazepine ring system via cuI/L-proline-catalyzed intramolecular aryl amination

Synlett

Volumn , Issue 12, 2008, Pages 1833-1836

  Guo, Lei ^a   Li, Ben ^b   Huang, Wenlong ^a   Pei, Gang ^b   Ma, Dawei ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Aryl bromide; Cross coupling; Ethers; Oxazepines

Indexed keywords

2 AMINOPHENOL; 2 BROMOBENZYL BROMIDE DERIVATIVE; BROMINE DERIVATIVE; COPPER DERIVATIVE; COPPER IODIDE; OXAZEPINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PROLINE;

AMINATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; SUBSTITUTION REACTION;

EID: 48349113711     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1078506     Document Type: Article

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39. 4, and concentrated. The residual oil was loaded on a silica gel column and eluted with 1:10 EtOAc-PE to afford the etherification product.
40. 4, and concentrated. The crude product was purified by column chromatography on silica gel to provide the coupling product.
41. +: 298.1438; found: 298.1432.
42. +: 248.1070; found: 248.1068.
43. +.
44. +: 242.1179; found: 242.1176.