Genomic instability and proliferative activity as risk factors for distant metastases in breast cancer

British Journal of Cancer

Volumn 99, Issue 3, 2008, Pages 513-519

  Li, L ^a   Mu, K ^a   Zhou, G ^a   Lan, L ^b   Auer, G ^b   Zetterberg, A ^b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Breast cancer; Distant metastases; Ploidy; Proliferative activity

Indexed keywords

BIOCHEMICAL MARKER; CYCLIN A; KI 67 ANTIGEN;

ANEUPLOIDY; ARTICLE; BREAST CANCER; BREAST TUMOR; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISTANT METASTASIS; FOLLOW UP; GENOMIC INSTABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; PLOIDY; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RISK FACTOR;

ANEUPLOIDY; BREAST NEOPLASMS; CELL PROLIFERATION; CYCLIN A; GENOMIC INSTABILITY; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; NEOPLASM METASTASIS; RISK FACTORS;

EID: 48349110525     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604479     Document Type: Article

References (33)

1. Ahlin C, Aaltonen K, Amini R-M, Nevanlinna H, Fjällskog M-L, Blomqvis C (2007) Ki67 and cyclin A as prognostic factors in early breast cancer. What are the optimal cut-off values? Histopathology 51(4): 491-498
2. Auer GU, Caspersson TO, Wallgren AS (1980) DNA content and survival in mammary carcinoma. Anal Quant Cytol 2: 161-165
3. Baldini E, Camerini A, Sgambato A, Prochilo T, Capodanno A, Pasqualetti F, Orlandini C, Resta L, Bevilacqua G, Collecchi P (2006) Cyclin A and E2F1 overexpression correlate with reduced disease-free survival in node-negative breast cancer patients. Anticancer Res 26: 4415-4421
4. Beresford MJ, Wilson GD, Makris A (2006) Measuring proliferation in breast cancer: practicalities and applications. Breast Cancer Res 8: 216
5. Blegen H, Ghadimi BM, Jauho A, Zetterberg A, Eriksson E, Auer G, Ried T (2001) Genetic instability promotes the acquisition of chromosomal imbalances in T1b and T1c breast adeno-carcinomas. Anal Cell Pathol 22: 123-131
6. Bukholm IR, Bukholm G, Nesland JM (2001) Over-expression of cyclin A is highly associated with early relapse and reduced survival in patients with primary breast carcinomas. Int J Cancer 93: 283-287
7. Colozza M, Azambuja E, Cardoso F, Sotiriou C, Larsimont D, Piccart MJ (2005) Proliferative markers as prognostic and predictive tools in early breast cancer: where are we now? Ann Oncol 16: 1723-1739
8. Cornelisse CJ, van de Velde CJ, Caspers RJ, Moolenaar AJ, Hermans J (1987) DNA ploidy and survival in breast cancer patients. Cytometry 8: 225-234
9. de Azambuja E, Cardoso F, de Castro Jr G, Colozza M, Mano MS, Durbecq V, Sotiriou C, Larsimont D, Piccart-Gebhart MJ, Paesmans M (2007) Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients. Br J Cancer 96: 1504-1513
10. Elston CW, Ellis JO (1991) Pathological prognostic factors in breast cancer: experience from a long study with long term follow up. Histopathology 19: 403-410
11. Erlandsson F, Linnman C, Ekholm S, Bengtsson E, Zetterberg A (2000) A detailed analysis of cyclin A accumulation at the G(1)/S border in normal and transformed cells. Exp Cell Res 259: 86-95
12. Falkmer UG, Hagmar T, Auer G (1990) Efficacy of combined image and flow cytometric DNA assessments in human breast cancer: a methodological study based on a routine histopathological material of 2024 excised tumour specimens. Anal Cell Pathol 2: 297-312
13. Fallenius AG, Auer GU, Carstensen JM (1988a) Prognostic significance of DNA measurements in 409 consecutive breast cancer patients. Cancer 62: 331-341
14. Fallenius AG, Franzen SA, Auer GU (1988b) Predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors. A retrospective study of 227 consecutive cases. Cancer 62: 521-530
15. Forsslund G, Nilsson B, Zetterberg A (1996) Near tetraploid prostate carcinoma. Methodological and prognostic aspects. Cancer 78: 1748-1755
16. Forsslund G, Zetterberg A (1990) Ploidy level determinationsin high-grade and low-grade malignant variants of prostatic carcinoma. Cancer Res 50: 4281-4285
17. Gerdes J (1990) Seminars in Cancer Biology, Vol. 1, pp 99-206. Saunders Scientific Publications: London, New York
18. Hicks J, Krasnitz A, Lakshmi B, Navin NE, Riggs M, Leibu E, Esposito D, Alexander J, Troge J, Grubor V, Yoon S, Wigler M, Ye K, Borresen-Dale AL, Naume B, Schlicting E, Norton L, Hagerstrom T, Skoog L, Auer G, Maner S, Lundin P, Zetterberg A (2006) Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res 16: 1465-1479
19. Jalava P, Kuopio T, Juntti-Patinen L, Kotkansalo T, Kronqvist P, Collan Y (2006) Ki67 immunohistochemistry: a valuable marker in prognostication but with a risk of misclassification: proliferation subgroups formed based on Ki67 immunoreactivity and standardized mitotic index. Histopathology 48: 674-682
20. Hunt T (1991) Cyclins and their partners: from a simple idea to complicated reality. Semin Cell Biol 2: 213-222
21. Kallioniemi A, Kallioniemi OP, Piper J, Tanner M, Stokke T, Chen L, Smith HS, Pinkel D, Gray JW, Waldman FM (1994) Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization. Proc Natl Acad Sci USA 91: 2156-2160
22. Kallioniemi OP, Hietanen T, Mattila J, Lehtinen M, Lauslahti K, Koivula T (1987) Aneuploid DNA content and high S-phase fraction of tumour cells are related to poor prognosis in patients with primary breast cancer. Eur J Cancer Clin Oncol 23: 277-282
23. Kronenwett U, Huwendiek S, Castro J, Ried T, Auer G (2005) Characterisation of breast fine-needle aspiration biopsies by centrosome aberrations and genomic instability. Br J Cancer 92: 389-395
24. Kronenwett U, Ploner A, Zetterberg A, Bergh J, Hall P, Auer G, Pawitan Y (2006) Genomic instability and prognosis in breast carcinomas. Cancer Epidemiol Biomarkers Prev 15: 1630-1635
25. Kuhling H, Alm P, Olsson H, Ferno M, Baldetorp B, Parwaresch R, Rudolph P (2003) Expression of cyclins E, A, and B, and prognosis in lymph node-negative breast cancer. J Pathol 199: 424-431
26. Nurse P (1994) Ordering S phase and M phase in the cell cycle. Cell 79: 547-550
27. Poikonen P, Sjostrom J, Amini RM, Villman K, Ahlgren J, Blomqvist C (2005) Cyclin A as a marker for prognosis and chemotherapy response in advanced breast cancer. Br J Cancer 93: 515 -519
28. Railo M, Lundin J, Haglund C, von Smitten K, Nordling S (2007) Ki-67, p53, ER receptors, ploidy and S phase as long-term prognostic factors in T1 node-negative breast cancer. Tumour Biol 28: 45-51
29. Ried T, Just KE, Holtgreve-Grez H, du Manoir S, Speicher MR, Schrock E, Latham C, Blegen H, Zetterberg A, Cremer T, Thomas C, Gert A (1995) Comparative genomic hybridization of formalin-fixed, paraffin-embedded breast tumors reveals different patterns of chromosomal gains and losses in fibroadenomas and diploid and aneuploid carcinomas. Cancer Res 55: 5415-5423
30. Sherr CJ (1993) Mammalian G1 cyclins. Cell 73: 1059-1065
31. Trere D, Ceccarelli C, Migaldi M, Santini D, Taffurelli M, Tosti E, Chieco P, Derenzini M (2006) Cell proliferation in breast cancer is a major determinant of clinical outcome in node-positive but not in node-negative patients. Appl Immunohistochem Mol Morphol 14: 314-323
32. van Diest PJ, van der Wall E, Baak JP (2004) Prognostic value of proliferation in invasive breast cancer: a review. J Clin Pathol 57: 675-681
33. Zetterberg A, Esposti PL (1980) Prognostic significance of nuclear DNA levels in prostatic carcinoma. Scand J Urol Nephrol Suppl 55: 53-58