Theory and computation show that Asp463 is the catalytic proton donor in human endoplasmic reticulum α-(1→2)-mannosidase I

Carbohydrate Research

Volumn 343, Issue 13, 2008, Pages 2235-2242

  Cantú, David ^a   Nerinckx, Wim ^b   Reilly, Peter J ^a  

^a Iowa State University   (United States)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

AutoDock; Catalytic residues; Endoplasmic reticulum mannosidase I; GH47; H++

Indexed keywords

PROTONS; SUGARS;

ENDOPLASMIC RETICULUM (EI); GLYCOSIDE HYDROLASE (GH); GLYCOSIDIC BONDS; MANNOSIDASE; PROTON DONORS;

COMPUTATION THEORY;

ALPHA (1-2)MANNOSIDASE I; CARBOHYDRATE DERIVATIVE; FUNGAL ENZYME; MANNOSIDASE; WATER;

ARTICLE; CATALYSIS; DISSOCIATION CONSTANT; ENDOPLASMIC RETICULUM; ENZYME STABILITY; ISOMER; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON TRANSPORT; THEORY;

ASPARTIC ACID; BINDING SITES; CARBOHYDRATES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; ENDOPLASMIC RETICULUM; HUMANS; HYDROGEN-ION CONCENTRATION; MANNOSIDASES; MODELS, CHEMICAL; MOLECULAR CONFORMATION; OXYGEN; PROTONS; WATER;

EID: 48349097076     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2008.05.026     Document Type: Article

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