Synthesis of 3-(2-pyridyl)-2-substituted-quinazolin-4(3H)-ones as new analgesic and anti-inflammatory agents

Biomedicine and Pharmacotherapy

Volumn 62, Issue 7, 2008, Pages 454-461

  Alagarsamy, V ^a   Solomon, V Raja ^b   Murugan, M ^a   Sankaranarayanan, R ^a   Periyasamy, P ^a   Deepa, R ^a   Anandkumar, T Durai ^c  

^a ARULMIGU KALASALINGAM COLLEGE OF PHARMACY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

^c JSS COLLEGE OF PHARMACY   (India)

Author keywords

Analgesic; Anti inflammatory activity; Quinazoline

Indexed keywords

2 (1 ETHYLPROPYLIDENE)HYDRAZINO 3 (2 PYRIDYL)QUINAZOLIN 4(3H) ONE; 2 (1 METHYLBUTYLIDENE)HYDRAZINO 3 (2 PYRIDYL)QUINAZOLIN 4(3H) ONE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTIINFLAMMATORY AGENT; DICLOFENAC; QUINAZOLINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ULCEROGENESIS;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; EDEMA; FEMALE; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PYRIDINES; QUINAZOLINONES; RATS; REFERENCE STANDARDS; SPECTROPHOTOMETRY, INFRARED; STOMACH ULCER;

EID: 48249152537     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2006.10.003     Document Type: Article

References (19)

1. van Ryn J., and Botting R.M. New insights into the mode of action of anti-inflammatory drugs. Inflamm Res 44 (1995) 1-10
2. van Ryn J., Trummlitz G., and Pairet M. COX-2 selectivity and inflammatory processes. Curr Med Chem 7 (2000) 1145-1161
3. van Ryn J. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231 (1971) 232-235
4. Beuck M. Nonsteroidal antiinflammatory drugs: a new generation of cyclooxygenase inhibitors. Angew Chem Int Ed 38 (1999) 631-633
5. Alagarsamy V., Revathi R., Vijayakumar S., and Ramseshu K.V. Synthesis and pharmacological investigation of some novel 2,3-disubstituted quinazolin-4(3H)-ones as analgesic and antiinflammatory agents. Pharmazie 58 (2003) 4-8
6. Alagarsamy V., Thangathirupathy A., Mandal S.C., Rajasekaran S., Vijayakumar S., Revathi R., et al. Pharmacological evaluation of 2-substituted (1,3,4) thiadiazolo quinazolines. Indian J Pharm Sci 68 (2006) 108-111
7. Bhalla M., Srivatava V.K., Bhalla T.N., and Shanker K. Anti-inflammatory and analgesic activity of indolyl quinazolones and their congeners. Arzneimittelforschung 43 (1993) 595-600
8. Zappalà M., Grasso S., Micale N., Zuccalà G., Menniti F.S., Ferreri G., et al. 1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents. Bioorg Med Chem Lett 13 (2003) 4427-4430
9. Chao Q., Deng L., Shih H., Leoni L.M., Genini D., Carson D.A., et al. Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor. J Med Chem 42 (1999) 3860-3873
10. Alagarsamy V., Muthukumar V., Pavalarani N., Vasanthanathan P., and Revathi R. Synthesis, analgesic and anti-inflammatory activities of some novel 2,3-disubstituted quinazolin-4(3H)-ones. Biol Pharm Bull 26 (2003) 557-559
11. Alagarsamy V., Solomon V.R., Vanikavitha G., Paluchamy V., Chandran M.R., Sujin A.A., et al. Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones. Biol Pharm Bull 25 (2002) 1432-1435
12. Alagarsamy V., Murugananthan G., and Venkateshperumal R. Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones. Biol Pharm Bull 26 (2003) 1711-1714
13. Alagarsamy V., Rajesh R., Ramaseshu M., Vijaykumar S., Ramseshu K.V., and Duraianandakumar T. Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones. Biol Pharm Bull 27 (2004) 652-656
14. Kulkarni S.K. Heat and other physiological stress-induced analgesia: catecholamine mediated and naloxone reversible response. Life Sci 27 (1980) 185-188
15. Amour R.E., and Smith D.L. A method for determinating loss of pain sensation. J Pharmacol Exp Ther 72 (1941) 74-78
16. Winter C.A., Risely E.A., and Nuss G.W. Carregeenin induced oedema in hind paw of the rat as assay for antiinflammatory drugs. Exp Biol Med 111 (1962) 544-547
17. Goel R.K., Chakrabarti A., and Sanyal A.K. The effect of biological variables on the anti-ulcerogenic effect of vegetable plantain banana. Planta med 29 (1985) 85-88
18. Shay M., Komarov S.A., Fels D., Meranze D., Grunstein H., and Siplet H. A simple method for the uniform production of gastric ulceration in the rats. Gastroenterol 5 (1945) 43-61
19. Ganguly A.K., and Bhatnagar O.P. Effect of bilateral adrenalectomy on production of restraint ulcers in the stomach of albino rats. Can J Physilo Pharmacol 51 (1973) 748-750