Flavin-dependent thymidylate synthase X limits chromosomal DNA replication

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 9948-9952

  Escartin, Frédéric ^a,b,c   Skouloubris, Stéphane ^c   Liebl, Ursula ^a,b   Myllykallio, Hannu ^c  

^a LABORATOIRE D OPTIQUE ET BIOSCIENCES   (France)

^b INSERM   (France)

^c INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

Author keywords

Gene replacement; Genome evolution; Nucleotide metabolism; PBCV 1; Thymidylate synthesis

Indexed keywords

ENZYME; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHETASE A; THYMIDYLATE SYNTHETASE X;

ARCHAEBACTERIUM; ARTICLE; BACTERIUM; CATALYSIS; CHROMOSOME REPLICATION; CONTROLLED STUDY; DNA REPLICATION; GENOME; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROKARYOTE; STATISTICAL ANALYSIS;

BACTERIA (MICROORGANISMS); PARAMECIUM BURSARIA CHLORELLA VIRUS 1; PROKARYOTA;

EID: 48249142369     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801356105     Document Type: Article

References (41)

1. Myllykallio H, et al. (2002) An alternative flavin-dependent mechanism for thymidylate synthesis. Science 297:105-107.
2. Carreras CW, Santi DV (1995) The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 64:721-762.
3. Leduc D, et al. (2007) Flavin-dependent thymidylate synthase ThyX activity: Implications for the folate cycle in bacteria. J Bacteriol 189:8537-8545.
4. Finer-Moore JS, Santi DV, Stroud RM (2003) Lessons and conclusions from dissecting the mechanism of a bisubstrate enzyme: Thymidylate synthase mutagenesis, function, and structure. Biochemistry 42:248-256.
5. Galperin MY, Koonin EV (2000) Who's your neighbor? New computational approaches for functional genomics. Nat Biotechnol 18:609-613.
6. Leduc D, et al. (2004) Two distinct pathways for thymidylate (dTMP) synthesis in (hyper)thermophilic Bacteria and Archaea. Biochem Soc Trans 32:231-235.
7. Leduc D, et al. (2004) Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers. Proc Natl Acad Sci USA 101:7252-7257.
8. Graziani S, et al. (2004) Functional analysis of FAD-dependent thymidylate synthase ThyX from Paramecium bursaria Chlorella virus-1. J Biol Chem 279:54340-54347.
9. Graziani S, et al. (2006) Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX. J Biol Chem 281:24048-24057.
10. Zhong J, Skouloubris S, Dai Q, Myllykallio H, Barbour AG (2006) Function and evolution of plasmid-borne genes for pyrimidine biosynthesis in Borrelia spp. J Bacteriol 188:909-918.
11. Chernyshev A, Fleischmann T, Koehn EM, Lesley SA, Kohen A (2007) The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS). Chem Commun 27:2861-2863.
12. Helmstetter, C (1996) Timing of synthetic activities in the cell cycle. Escherichia coli and Salmonella: Cellular and Molecular Biology, eds Neidhardt FC, et al. (Am Soc Microbiol, Washington, DC), pp 1627-1639.
13. Rocha EP, Danchin A (2002) Base composition bias might result from competition for metabolic resources. Trends Genet 18:291-294.
14. Bentley SD, Parkhill J (2004) Comparative genomic structure of prokaryotes. Annu Rev Genet 38:771-792.
15. Nakabachi A, et al. (2006) The 160-kilobase genome of the bacterial endosymbiont Carsonella. Science 314:267.
16. Blanc G, et al. (2007) Reductive genome evolution from the mother of Rickettsia. PLoS Genet 3:e14.
17. Marais GA, Calteau A, Tenaillon O (2007) Mutation rate and genome reduction in endosymbiotic and free-living bacteria. Genetica 10.1007/s10709-007-9226-6.
18. Giladi M, Bitan-Banin G, Mevarech M, Ortenberg R (2002) Genetic evidence for a novel thymidylate synthase in the halophilic archaeon Halobacterium salinarum and in Campylobacter jejuni. FEMS Microbiol Lett 216:105-109.
19. Derbise A, Lesic B, Dacheux D, Ghigo JM, Carniel E (2003) A rapid and simple method for inactivating chromosomal genes in Yersinia. FEMS Immunol Med Microbiol 38:113-116.
20. Chaveroche MK, Ghigo JM, d'Enfert C (2000) A rapid method for efficient gene replacement in the filamentous fungus Aspergillus nidulans. Nucleic Acids Res 28:E97.
21. Servant P, et al. (2007) The ClpPX protease is required for radioresistance and regulates cell division after gamma-irradiation in Deinococcus radiodurans. Mol Microbiol 66:1231-1239.
22. Hallin PF, Ussery DW (2004) CBS Genome Atlas Database: A dynamic storage for bioinformatic results and sequence data. Bioinformatics 20:3682-3686.
23. Riber L, Lobner-Olesen A (2005) Coordinated replication and sequestration of oriC and dnaA are required for maintaining controlled once-per-cell-cycle initiation in Escherichia coli. J Bacteriol 187:5605-5613.
24. Bremer H, Churchward G (1977) An examination of the Cooper-Helmstetter theory of DNA replication in bacteria and its underlying assumptions. J Theor Biol 69:645-654.
25. Markowitz VM, et al. (2006) The integrated microbial genomes (IMG) system. Nucleic Acids Res 34:D344-D348.
26. Tatusov RL, et al. (2001) The COG database: New developments in phylogenetic classification of proteins from complete genomes. Nucleic Acids Res 29:22-28.
27. Tatusov RL, Koonin EV, Lipman DJ (1997) A genomic perspective on protein families. Science 278:631-637.
28. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410.
29. Altschul SF, et al. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.
30. Couturier E, Rocha EP (2006) Replication-associated gene dosage effects shape the genomes of fast-growing bacteria but only for transcription and translation genes. Mol Microbiol 59:1506-1518.
31. Liu L, Santi DV (1993) Asparagine 229 in thymidylate synthase contributes to, but is not essential for, catalysis. Proc Natl Acad Sci USA 90:8604-8608.
32. Lambden PR, Pickett MA, Clarke IN (2006) The effect of penicillin on Chlamydia trachomatis DNA replication. Microbiology 152:2573-2578.
33. Burbage CD, Binder BJ (2007) Relationship between cell cycle and light-limited growth rate in oceanic Prochlorococcus (mit9312) and Synechococcus (wh8103) (cyanobacteria). J Phycol 43:266-274.
34. Myllykallio H, et al. (2000) Bacterial mode of replication with eukaryotic-like machinery in a hyperthermophilic archaeon. Science 288:2212-2215.
35. Lundgren M, Andersson A, Chen L, Nilsson P, Bernander R (2004) Three replication origins in Sulfolobus species: Synchronous initiation of chromosome replication and asynchronous termination. Proc Natl Acad Sci USA 101:7046-7051.
36. Sharpe ME, Hauser PM, Sharpe RG, Errington J (1998) Bacillus subtilis cell cycle as studied by fluorescence microscopy: Constancy of cell length at initiation of DNA replication and evidence for active nucleoid partitioning. J Bacteriol 180:547-555.
37. Altenbern RA (1973) Chromosomal mapping of Brucella abortus, strain 19. Can J Microbiol 19:109-112.
38. Higgins ML, Koch AL, Dicker DT, Daneo-Moore L (1986) Autoradiographic studies of chromosome replication during the cell cycle of Streptococcus faecium. J Bacteriol 168:541-547.
39. Meacock PA, Pritchard RH (1975) Relationship between chromosome replication and cell division in a thymineless mutant of Escherichia coli B/r. J Bacteriol 122:931-942.
40. Altenbern RA (1968) Chromosome mapping in Staphylococcus aureus. J Bacteriol 95:1642-1646.
41. Rasmussen T, Jensen RB, Skovgaard O (2007) The two chromosomes of Vibrio cholerae are initiated at different time points in the cell cycle. EMBO J 26:3124-3131.