Manipulating the metazoan mitochondrial genome with targeted restriction enzymes

Science

Volumn 321, Issue 5888, 2008, Pages 575-577

  Xu, Hong ^a   DeLuca, Steven Z ^a   O'Farrell, Patrick H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA; RESTRICTION ENDONUCLEASE;

ENZYME ACTIVITY; FLY; GENETIC ANALYSIS; GENOME; METAZOAN; MITOCHONDRIAL DNA; MUTATION;

ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA CLEAVAGE; DROSOPHILA; GENE MUTATION; GERM LINE; GROWTH RETARDATION; LIFESPAN; MALE FERTILITY; MALE STERILITY; METAZOON; MITOCHONDRIAL GENETICS; MUSCLE ATROPHY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BACTERIAL PROTEINS; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA RESTRICTION ENZYMES; DNA, MITOCHONDRIAL; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; EYE; FEMALE; GENOME, INSECT; GENOME, MITOCHONDRIAL; INFERTILITY, MALE; MALE; MITOCHONDRIAL DISEASES; MORPHOGENESIS; MUSCLES; MUSCULAR DYSTROPHY, ANIMAL; MUTATION; SPERMATOGENESIS;

METAZOA;

EID: 48249139446     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1160226     Document Type: Article

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13. We thank members of O'Farrell laboratory for comments on the manuscripts; M.-L. Wong and M. Sepanski for technical help with TEM; M. Fuller and A. W. Shermoen for help with examination of spermatogenesis and sperm in female reproductive organs; and Bloomington Stock Center for providing some Drosophila stocks. This work is supported by an NIH RO1 grant and a Sandler Family Supporting Foundation award to P.H.O. H.X. is supported by a postdoctoral fellowship from the Larry L. Hillblom Foundation.