Retinal and cerebral microvascular signs and diabetes the age, gene/environment susceptibility-reykjavik study

Diabetes

Volumn 57, Issue 6, 2008, Pages 1645-1650

  Qiu, Chengxuan ^a,h   Cotch, Mary Frances ^b   Sigurdsson, Sigurdur ^c   Garcia, Melissa ^a   Klein, Ronald ^d   Jonasson, Fridbert ^e,f   Klein, Barbara E K ^d   Eiriksdottir, Gudny ^c   Harris, Tamara B ^a   Van Buchem, Mark A ^g   Gudnason, Vilmundur ^c,e   Launer, Lenore J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

^c ICELANDIC HEART ASSOCIATION   (Iceland)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e UNIVERSITY OF ICELAND   (Iceland)

^f LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^h AGING RESEARCH CENTER   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTIHYPERTENSIVE AGENT;

ADULT; AGE DETERMINATION; AGED; ARTICLE; BRAIN DAMAGE; BRAIN HEMORRHAGE; BRAIN INFARCTION; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CLINICAL EVALUATION; COGNITIVE DEFECT; CONTROLLED STUDY; DEMOGRAPHY; DIABETES MELLITUS; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; FEMALE; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROANEURYSM; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION BASED CASE CONTROL STUDY; PRIORITY JOURNAL; RETINA DISEASE; RETINAL FOCAL ARTERIOLAR NARROWING; RETINAL MICROVASCULAR LESION; RETINOPATHY; RISK FACTOR; WHITE MATTER; ARTERIOLE; BRAIN CIRCULATION; CLINICAL TRIAL; ENVIRONMENT; GENETIC PREDISPOSITION; GENETICS; ICELAND; MICROCIRCULATION; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA; RETINA BLOOD VESSEL; VENULE;

AGED; AGED, 80 AND OVER; ARTERIOLES; CEREBRAL HEMORRHAGE; CEREBROVASCULAR CIRCULATION; DIABETES MELLITUS; ENVIRONMENT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ICELAND; MAGNETIC RESONANCE IMAGING; MALE; MICROCIRCULATION; MIDDLE AGED; RETINA; RETINAL VESSELS; VENULES;

EID: 48249133296     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1455     Document Type: Article

References (40)

1. Wong TY, Mcintosh R: Systemic associations of retinal microvascular signs: a review of recent population-based studies. Ophthalmic Physiol Opt 25:195-204, 2005
2. Patton N, Aslam T, Macgillivray T, Pattie A, Deary IJ, Dhillon B: Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures. J Anat 206:319-348, 2005
3. Wong TY, Klein R, Sharrett AR, Manolio TA, Hubbard LD, Marino EK, Kuller L, Burke G, Tracy RP, Polak JF, Gottdiener JS, Siscovick DS: The prevalence and risk factors of retinal microvascular abnormalities in older persons: the Cardiovascular Health Study. Ophthalmology 110:658-666, 2003
4. Wong TY, Duncan BB, Golden SH, Klein R, Couper DJ, Klein BE, Hubbard LD, Sharrett AR, Schmidt MI: Associations between the metabolic syndrome and retinal microvascular signs: the Atherosclerosis Risk in Communities Study. Invest Ophthalmol Vis Sci 45:2949-2954, 2004
5. Wong TY, Klein R, Couper DJ, Cooper LS, Shahar E, Hubbard LD, Wofford MR, Sharrett AR: Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study. Lancet 358:1134-1140, 2001
6. Wong TY, Klein R, Sharrett AR, Couper DJ, Klein BE, Liao DP, Hubbard LD, Mosley TH: Cerebral white matter lesions, retinopathy, and incident clinical stroke. JAMA 288:67-74, 2002
7. Mitchell P, Wang JJ, Wong TY, Smith W, Klein R, Leeder SR: Retinal microvascular signs and risk of stroke and stroke mortality. Neurology 65:1005-1009, 2005
8. Longstreth W Jr, Larsen EK, Klein R, Wong TY, Sharrett AR, Lefkowitz D, Manolio TA: Associations between findings on cranial magnetic resonance imaging and retinal photography in the elderly: the Cardiovascular Health Study. Am J Epidemiol 165:78-84, 2007
9. Cordonnier C, Al-Shahi Salman R, Wardlaw J: Spontaneous brain microb- leeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 130:1988-2003, 2007
10. Fazekas F, Kleinert R, Roob G, Kleinert G, Kapeller P, Schmidt R, Hartung HP: Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. Am J Neuroradiol 20:637-642, 1999
11. Rosand J, Muzikansky A, Kumar A, Wisco JJ, Smith EE, Betensky RA, Greenberg SM: Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 58:459 -462, 2005
12. Smith EE, Eichler F: Cerebral amyloid angiopathy and lobar intracerebral hemorrhage. Arch Neurol 63:148-151, 2006
13. Peila R, Rodriguez BL, Launer LJ: Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study. Diabetes 51:1256-1262, 2002
14. Launer LJ: Diabetes and brain aging: epidemiologic evidence. Curr Diab Rep 5:59 -63, 2005
15. Xu W, Qiu C, Winblad B, Fratiglioni L: The effect of borderline diabetes on the risk of dementia and Alzheimer's disease. Diabetes 56:211-216, 2007
16. Schmidt R, Launer LJ, Nilsson LG, Pajak A, Sans S, Berger K, Breteler MM, de Ridder M, Dufouil C, Fuhrer R, Giampaoli S, Hofman A: Magnetic resonance imaging of the brain in diabetes: the Cardiovascular Determinants of Dementia (CASCADE) Study. Diabetes 53:687-692, 2004
17. Korf ES, White LR, Scheltens P, Launer LJ: Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study. Diabetes Care 29:2268-2274, 2006
18. Harris T, Launer LJ, Eiriksdottir G, Kjartansson O, Jonsson PV, Sigurdsson G, Thorgeirsson G, Aspelund T, Garcia ME, Cotch MF, Hoffman HJ, Gudnason V: Age, Gene/Environment Susceptibility-Reykjavik Study: mul- tidisciplinary applied phenomics. Am J Epidemiol 165:1076-1087, 2007
19. Klein R, Davis MD, Magli YL, Segal P, Klein BE, Hubbard L: The Wisconsin age-related maculopathy grading system. Ophthalmology 98:1128-1134, 1991
20. Sveinbjornsdottir S, Sigurdsson S, Aspelund T, Kjartansson O, Eiriksdottir G, Valtysdottir B, Lopez OL, van Buchem MA, Jonsson PV, Gudnason V, Launer LJ: Cerebral microbleeds in the population based AGES Reykjavik Study: prevalence and location. J Neurol Neurosurg Psychiatry.12 February 2008 [Epub ahead of print]
21. Achten E, Breteler MM, de Leeuw FE, de Groot JC, Scheltens P, Heyboer R, Oudkerk M: Rating scale for age related brain changes. Imaging Decisions MRI 4:10-19, 2000
22. Jonsdottir LS, Sigfusson N, Gudnason V, Sigvaldason H, Thorgeirsson G: Do lipids, blood pressure, diabetes, and smoking confer equal risk of myocardial infarction in women as in men? The Reykjavik Study. J Car- diovasc Risk 9:67-76, 2002
23. American Diabetes Association: Position Statement: Diagnosis and classification of diabetes mellitus. Diabetes Care 31 (Suppl. 1):S55-S60, 2008
24. Cooper LS, Wong TY, Klein R, Sharrett AR, Bryan RN, Hubbard LD, Couper DJ, Heiss G, Sorlie PD: Retinal microvascular abnormalities and MRI- defined subclinical cerebral infarction: the Atherosclerosis Risk in Communities Study. Stroke 37:82-86, 2006
25. Koennecke HC: Cerebral microbleeds on MRI: prevalence, associations, and potential clinical implications. Neurology 66:165-171, 2006
26. Wong TY, Mitchell P: The eye in hypertension. Lancet 369:425-435, 2007
27. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL III, Klein R, for the American Diabetes Association: Retinopathy in diabetes. Diabetes Care 27 (Suppl. 1):S84-S87, 2004
28. Sharrett AR, Hubbard LD, Cooper LS, Sorlie PD, Brothers RJ, Nieto FJ, Pinsky JL, Klein R: Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study. Am J Epidemiol 150:263-270, 1999
29. Wong TY, Hubbard LD, Klein R, Marino EK, Kronmal R, Sharrett AR, Siscovick DS, Burke G, Tielsch JM: Retinal microvascular abnormalities and blood pressure in older people: the Cardiovascular Health Study. Br J Ophthalmol 86:1007-1013, 2002
30. Wong TY, Mitchell P: Hypertensive retinopathy. N Engl J Med 351:23102317, 2004
31. de Leeuw FE, de Groot JC, Oudkerk M, Witteman JC, Hofman A, van Gijn J, Breteler MM: Hypertension and cerebral white matter lesions in a prospective cohort study. Brain 125:765-772, 2002
32. Launer LJ: Epidemiology of white matter lesions. Top Magn Reson Imaging 15:365-367, 2004
33. Craft S, Watson GS: Insulin and neurodegenerative disease: shared and specific mechanisms. Lancet Neurol 3:169-178, 2004
34. Dickson DW, Sinicropi S, Yen SH, Ko LW, Mattiace LA, Bucala R, Vlassara H: Glycation and microglial reaction in lesions of Alzheimer's disease. Neurobiol Aging 17:733-743, 1996
35. Goldin A, Beckman JA, Schmidt AM, Creager MA: Advanced glycation end products: sparking the development of diabetic vascular injury. Circulation 114:597-605, 2006
36. Pfeifer LA, White LR, Ross GW, Petrovitch H, Launer LJ: Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study. Neurology 58:1629-1634, 2002
37. Johnson LV, Leitner WP, Rivest AJ, Staples MK, Radeke MJ, Anderson DH: The Alzheimer's Ap-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad SciUSA99:11830-11835, 2002
38. Klein R, Klein BE, Tomany SC, Wong TY: The relation of retinal microvas- cular characteristics to age-related eye disease: the Beaver Dam eye study. Am J Ophthalmol 137:435-444, 2004
39. Werring DJ, Frazer DW, Coward LJ, Losseff NA, Watt H, Cipolotti L, Brown MM, Jager HR: Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI. Brain 127:2265-2275, 2004
40. Baker ML, Larsen EKM, Kuller LH, Klein R, Klein BEK, Siscovick DS, Bernick C, Manolio TA, Wong TY: Retinal microvascular signs, cognitive function, and dementia in older persons: the Cardiovascular Health Study. Stroke 38:2041-2047, 2007