메뉴 건너뛰기




Volumn 9, Issue 2, 1996, Pages 183-205

Aerosol bolus dispersion and aerosol-derived airway morphometry: Assessment of lung pathology and response to therapy, part 1

(1)  Blanchard, James D a  

a NONE   (United States)

Author keywords

aerosols; bolus; diagnosis; gas transport; lung anatomy; particle deposition; respiratory function tests

Indexed keywords

AEROSOL; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CYSTIC FIBROSIS; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; GAS MIXING; HUMAN; LUNG EMPHYSEMA; LUNG FUNCTION; LUNG GAS EXCHANGE; REVIEW; SPIROMETRY; TISSUE DISTRIBUTION;

EID: 0029955206     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.1996.9.183     Document Type: Review
Times cited : (35)

References (67)
  • 1
    • 2242420922 scopus 로고    scopus 로고
    • Aerosol bolus dispersion and aerosol-derived airway morphometry: Assessment of lung pathology and response to therapy, Part 2
    • in press
    • Blanchard, J.D. 1996. Aerosol bolus dispersion and aerosol-derived airway morphometry: Assessment of lung pathology and response to therapy, Part 2. J. Aerosol Med. 9 (in press).
    • (1996) J. Aerosol Med. , vol.9
    • Blanchard, J.D.1
  • 2
    • 0023832558 scopus 로고
    • Convective mixing in the human respiratory tract: Estimates with aerosol boli
    • Heyder, J., J.D. Blanchard, H.A. Feldman, and J.D. Brain. 1988. Convective mixing in the human respiratory tract: Estimates with aerosol boli. J. Appl. Physiol. 64:1273-1278.
    • (1988) J. Appl. Physiol. , vol.64 , pp. 1273-1278
    • Heyder, J.1    Blanchard, J.D.2    Feldman, H.A.3    Brain, J.D.4
  • 3
    • 0026700228 scopus 로고
    • Aerosol bolus dispersion and convective mixing in human and dog lungs and in physical models
    • Rosenthal, F.S., J.D. Blanchard, and P.J. Anderson. 1992. Aerosol bolus dispersion and convective mixing in human and dog lungs and in physical models. J. Appl. Physiol. 73:862-873.
    • (1992) J. Appl. Physiol. , vol.73 , pp. 862-873
    • Rosenthal, F.S.1    Blanchard, J.D.2    Anderson, P.J.3
  • 6
    • 84909715238 scopus 로고
    • Assessment of airway geometry with inert aerosols
    • Heyder, J. 1989. Assessment of airway geometry with inert aerosols. J. Aerosol Med. 2:89-97.
    • (1989) J. Aerosol Med. , vol.2 , pp. 89-97
    • Heyder, J.1
  • 7
    • 0028840942 scopus 로고
    • Peripheral airspace dimensions in patients with COPD
    • Beinert, T., P. Brand, J. Behr, C. Vogelmeier, and J. Heyder. 1995. Peripheral airspace dimensions in patients with COPD. Chest 108:998-1003.
    • (1995) Chest , vol.108 , pp. 998-1003
    • Beinert, T.1    Brand, P.2    Behr, J.3    Vogelmeier, C.4    Heyder, J.5
  • 9
    • 0014976153 scopus 로고
    • Validation of screening procedures
    • Cochrane, A.L., and W.W. Holland. 1971. Validation of screening procedures. Br. Med. Bull. 27:3-8.
    • (1971) Br. Med. Bull. , vol.27 , pp. 3-8
    • Cochrane, A.L.1    Holland, W.W.2
  • 11
    • 0028079818 scopus 로고
    • Detection of small air way dysfunction in asymptomatic smokers using aerosol bolus behavior
    • Anderson, P.J., K.G. Hardy, L.P. Gann, R. Cole, and F.C. Hiller. 1994. Detection of small air way dysfunction in asymptomatic smokers using aerosol bolus behavior. Am. J. Respir. Crit. Care Med. 150:995-1001.
    • (1994) Am. J. Respir. Crit. Care Med. , vol.150 , pp. 995-1001
    • Anderson, P.J.1    Hardy, K.G.2    Gann, L.P.3    Cole, R.4    Hiller, F.C.5
  • 12
    • 0023904246 scopus 로고
    • Use of aerosols to estimate mean air-space size in chronic obstructive pulmonary disease
    • Bennett, W.D., and G.C. Smaldone. 1988. Use of aerosols to estimate mean air-space size in chronic obstructive pulmonary disease. J. Appl. Physiol. 64:1554-1560.
    • (1988) J. Appl. Physiol. , vol.64 , pp. 1554-1560
    • Bennett, W.D.1    Smaldone, G.C.2
  • 13
    • 0023893855 scopus 로고
    • Development of an aerosol dispersion test to detect early changes in lung function
    • McCawley, M., and M. Lippmann. 1988. Development of an aerosol dispersion test to detect early changes in lung function. Am. Ind. Hyg. Assoc. J. 49:357-366.
    • (1988) Am. Ind. Hyg. Assoc. J. , vol.49 , pp. 357-366
    • McCawley, M.1    Lippmann, M.2
  • 14
    • 0014983776 scopus 로고
    • An aerosol inhalation apparatus for human single breath deposition studies
    • Palmes, E.D., and C.S. Wang. 1971. An aerosol inhalation apparatus for human single breath deposition studies. Am. Ind. Hyg. Assoc. J. 32:43-46.
    • (1971) Am. Ind. Hyg. Assoc. J. , vol.32 , pp. 43-46
    • Palmes, E.D.1    Wang, C.S.2
  • 15
    • 0021832870 scopus 로고
    • A model for determining alveolar and small airway dimensions from aerosol recovery data
    • Rosenthal, F.S. 1985. A model for determining alveolar and small airway dimensions from aerosol recovery data. J. Appl. Physiol. 58:582-591.
    • (1985) J. Appl. Physiol. , vol.58 , pp. 582-591
    • Rosenthal, F.S.1
  • 17
    • 0027487082 scopus 로고
    • Aerosol derived airway morphometry at different levels of lung inflation
    • Brand, P., T. Beinert, G. Fruhmann, A. Hillebrecht, and J. Heyder. 1993. Aerosol derived airway morphometry at different levels of lung inflation. J. Aerosol Med. 6:165-176.
    • (1993) J. Aerosol Med. , vol.6 , pp. 165-176
    • Brand, P.1    Beinert, T.2    Fruhmann, G.3    Hillebrecht, A.4    Heyder, J.5
  • 19
    • 0029046709 scopus 로고
    • Measuring alveolar dimensions at total lung capacity by aerosol-derived airway morphometry
    • Zeman, K.L., and W.D. Bennett. 1995. Measuring alveolar dimensions at total lung capacity by aerosol-derived airway morphometry. J. Aerosol Med. 8:135-147.
    • (1995) J. Aerosol Med. , vol.8 , pp. 135-147
    • Zeman, K.L.1    Bennett, W.D.2
  • 21
    • 15844428250 scopus 로고
    • Dispersion and deposition of aerosol bolus in human respiratory tract: Effect of particle size and flow rate
    • Hu, S.C., C.S. Kim, and P. Dewitt. 1995. Dispersion and deposition of aerosol bolus in human respiratory tract: Effect of particle size and flow rate. J. Aerosol Med. 8:125.
    • (1995) J. Aerosol Med. , vol.8 , pp. 125
    • Hu, S.C.1    Kim, C.S.2    Dewitt, P.3
  • 22
    • 0019427846 scopus 로고
    • Use of aerosols to estimate pulmonary air-space dimensions
    • Gebhart, J., J. Heyder, and W. Stahlhofen. 1981. Use of aerosols to estimate pulmonary air-space dimensions. J. Appl. Physiol. 51:465-476.
    • (1981) J. Appl. Physiol. , vol.51 , pp. 465-476
    • Gebhart, J.1    Heyder, J.2    Stahlhofen, W.3
  • 23
    • 0014112319 scopus 로고
    • The deposition of 0.5 μ diameter aerosols in the lungs of man
    • Muir, D.C.F., and C.N. Davies. 1967. The deposition of 0.5 μ diameter aerosols in the lungs of man. Ann. Occup. Hyg. 10:161-174.
    • (1967) Ann. Occup. Hyg. , vol.10 , pp. 161-174
    • Muir, D.C.F.1    Davies, C.N.2
  • 24
    • 0029747229 scopus 로고    scopus 로고
    • Relative toxicity of di(2-ethylhexyl) sebacate and related compounds in an in vivo hamster bioassay
    • Brain, J.D., J.D. Blanchard, J. Heyder, S.P. Wolfthal, and B.D. Beck. 1996. Relative toxicity of di(2-ethylhexyl) sebacate and related compounds in an in vivo hamster bioassay. Inhalation Toxicol. 8:579-593.
    • (1996) Inhalation Toxicol. , vol.8 , pp. 579-593
    • Brain, J.D.1    Blanchard, J.D.2    Heyder, J.3    Wolfthal, S.P.4    Beck, B.D.5
  • 26
    • 0000217553 scopus 로고
    • Interregional gas mixing and distribution
    • L.A. Engel and M. Pavia, eds. Marcel Dekker, New York
    • Engel, L.A. 1985. Interregional gas mixing and distribution. In L.A. Engel and M. Pavia, eds. Gas Mixing and Distribution in the Lung. Lung Biology in Health and Disease, Vol. 25. Marcel Dekker, New York, 287-358.
    • (1985) Gas Mixing and Distribution in the Lung. Lung Biology in Health and Disease , vol.25 , pp. 287-358
    • Engel, L.A.1
  • 28
    • 0016799804 scopus 로고
    • Measurement of axial diffusivities in a model of the bronchial airways
    • Scherer, P.W., L.H. Shendalman, N.M. Greene, and A. Bouhuys. 1975. Measurement of axial diffusivities in a model of the bronchial airways. J. Appl. Physiol. 38:719-723.
    • (1975) J. Appl. Physiol. , vol.38 , pp. 719-723
    • Scherer, P.W.1    Shendalman, L.H.2    Greene, N.M.3    Bouhuys, A.4
  • 29
    • 0014589699 scopus 로고
    • Flow patterns in models of the human bronchial airways
    • Schroter, R.C., and M.F. Sudlow. 1969. Flow patterns in models of the human bronchial airways. Respir. Physiol. 7:341-355.
    • (1969) Respir. Physiol. , vol.7 , pp. 341-355
    • Schroter, R.C.1    Sudlow, M.F.2
  • 31
    • 15844362924 scopus 로고
    • Chaotic mixing of aerosol particles in a rhythmically expanding pulmonary ascinus: Experimental studies
    • Tsuda, A., J.P. Butler, and Y. Otani. 1995. Chaotic mixing of aerosol particles in a rhythmically expanding pulmonary ascinus: Experimental studies. J. Aerosol Med. 8:71.
    • (1995) J. Aerosol Med. , vol.8 , pp. 71
    • Tsuda, A.1    Butler, J.P.2    Otani, Y.3
  • 32
    • 9444241096 scopus 로고
    • Behavior of airborne particles in the respiratory tract
    • G.E.W. Wolstenholme and J. Knight, eds. Churchill, London
    • Altshuler, B. 1969. Behavior of airborne particles in the respiratory tract. In G.E.W. Wolstenholme and J. Knight, eds. Circulatory and Mass Transport. Churchill, London, 215-235.
    • (1969) Circulatory and Mass Transport , pp. 215-235
    • Altshuler, B.1
  • 33
    • 0014918223 scopus 로고
    • Inhaled aerosol boluses in man
    • W.H. Walton, ed. Unwin Bros., Old Woking, England
    • Muir, D.C.F., K. Sweetland, and R.G. Love. 1971. Inhaled aerosol boluses in man. In W.H. Walton, ed. Inhaled Particles III. Unwin Bros., Old Woking, England, 81-89.
    • (1971) Inhaled Particles III , pp. 81-89
    • Muir, D.C.F.1    Sweetland, K.2    Love, R.G.3
  • 34
    • 0025788850 scopus 로고
    • The effect of ozone exposure on the dispersion of inhaled aerosol boluses in healthy human subjects
    • Keefe, M.J., W.D. Bennett, P. Dewitt, E. Seal, A.A. Strong, and T.R. Gerrity. 1991. The effect of ozone exposure on the dispersion of inhaled aerosol boluses in healthy human subjects. Am. Rev. Respir. Dis. 144:23-30.
    • (1991) Am. Rev. Respir. Dis. , vol.144 , pp. 23-30
    • Keefe, M.J.1    Bennett, W.D.2    Dewitt, P.3    Seal, E.4    Strong, A.A.5    Gerrity, T.R.6
  • 35
    • 0024819425 scopus 로고
    • Lung structure parameters estimated from modelling aerosol deposition in isolated dog lungs
    • Rosenthal, F.S. 1989. Lung structure parameters estimated from modelling aerosol deposition in isolated dog lungs. J. Appl. Physiol. 67:2014-2025.
    • (1989) J. Appl. Physiol. , vol.67 , pp. 2014-2025
    • Rosenthal, F.S.1
  • 36
    • 0025800406 scopus 로고
    • Effect of heart rate on aerosol recovery and dispersion in human conducting airways after periods of breathholding
    • Scheuch, G., and W. Stahlhofen. 1991. Effect of heart rate on aerosol recovery and dispersion in human conducting airways after periods of breathholding. Exp. Lung Res. 17:763-787.
    • (1991) Exp. Lung Res. , vol.17 , pp. 763-787
    • Scheuch, G.1    Stahlhofen, W.2
  • 38
    • 0025631414 scopus 로고
    • Pharmacon-induced airway obstruction in healthy subjects: Dose dependent changes of inspired aerosol boluses
    • Siekmeier, R., C.F. Schiller-Scotland, J. Gebhart, and H. Kronenberger. 1990. Pharmacon-induced airway obstruction in healthy subjects: Dose dependent changes of inspired aerosol boluses. J. Aerosol Sci. 21(Suppl. 1):S423-S426.
    • (1990) J. Aerosol Sci. , vol.21 , Issue.1 SUPPL.
    • Siekmeier, R.1    Schiller-Scotland, C.F.2    Gebhart, J.3    Kronenberger, H.4
  • 39
    • 0022465559 scopus 로고
    • Studies of gas mixing in the human lung by means of aerosols
    • Ramm, U., G. Rudolf, J. Heyder, and J. Gebhart. 1987. Studies of gas mixing in the human lung by means of aerosols. J. Aerosol Sci. 18:753-756.
    • (1987) J. Aerosol Sci. , vol.18 , pp. 753-756
    • Ramm, U.1    Rudolf, G.2    Heyder, J.3    Gebhart, J.4
  • 41
    • 0026985027 scopus 로고
    • Use of aerosol pulse parameters as a sensitive discriminator between middle-aged healthy smokers and non-smokers
    • Siekmeier, R., C.F. Schiller-Scotland, H. Kronenberger, and J. Gebhart. 1992. Use of aerosol pulse parameters as a sensitive discriminator between middle-aged healthy smokers and non-smokers. J. Aerosol Sci. 23(Suppl. 1):S483-S486.
    • (1992) J. Aerosol Sci. , vol.23 , Issue.1 SUPPL.
    • Siekmeier, R.1    Schiller-Scotland, C.F.2    Kronenberger, H.3    Gebhart, J.4
  • 42
    • 15844419238 scopus 로고
    • Aerosol bolus dispersion and recovery: Comparison with tests of ventilation distribution
    • Brown, J.S., W.D. Bennett, K. Hohneker, and T.R. Gerrity. 1995. Aerosol bolus dispersion and recovery: Comparison with tests of ventilation distribution. J. Aerosol Med. 8:123.
    • (1995) J. Aerosol Med. , vol.8 , pp. 123
    • Brown, J.S.1    Bennett, W.D.2    Hohneker, K.3    Gerrity, T.R.4
  • 44
    • 15844386634 scopus 로고
    • Diagnostic utility of aerosol bolus behavior during bronchoprovocation in mild asthmatics
    • Anderson, P.J., L.P. Gann, R.C. Walls, K.B. Tennal, and F.C. Hiller. 1995. Diagnostic utility of aerosol bolus behavior during bronchoprovocation in mild asthmatics. J. Aerosol Med. 8:122.
    • (1995) J. Aerosol Med. , vol.8 , pp. 122
    • Anderson, P.J.1    Gann, L.P.2    Walls, R.C.3    Tennal, K.B.4    Hiller, F.C.5
  • 46
    • 0028424092 scopus 로고
    • Influence of asthma bronchiale on convective gas transport in patients with asthma bronchiale
    • Siekmeier, R., C.F. Schiller-Scotland, and W. Stahlhofen. 1994. Influence of asthma bronchiale on convective gas transport in patients with asthma bronchiale. J. Aerosol Sci. 25(Suppl. 1):S501-S502.
    • (1994) J. Aerosol Sci. , vol.25 , Issue.1 SUPPL.
    • Siekmeier, R.1    Schiller-Scotland, C.F.2    Stahlhofen, W.3
  • 47
    • 2242452985 scopus 로고
    • Aerosol morphometry and aerosol dispersion to study obstructive lung disease
    • Beinert, T., P. Brand, A. Huber, W. Stahlhofen, and J. Heyder. 1990. Aerosol morphometry and aerosol dispersion to study obstructive lung disease. Am. Rev. Respir. Dis. 141(Suppl.):A236.
    • (1990) Am. Rev. Respir. Dis. , vol.141 , Issue.SUPPL.
    • Beinert, T.1    Brand, P.2    Huber, A.3    Stahlhofen, W.4    Heyder, J.5
  • 48
    • 85016521507 scopus 로고
    • Aerosol dispersion and shape of the pressure-flow curve in patients with obstructive lung disease
    • Rieger, C., T. Beinert, P. Brand, and J. Heyder. 1993. Aerosol dispersion and shape of the pressure-flow curve in patients with obstructive lung disease. J. Aerosol Med. 6(Suppl.):66.
    • (1993) J. Aerosol Med. , vol.6 , Issue.SUPPL. , pp. 66
    • Rieger, C.1    Beinert, T.2    Brand, P.3    Heyder, J.4
  • 53
    • 0011831352 scopus 로고
    • Dose-dependent changes of airway resistance and aerosol pulse dispersion in cases of pharmacologically induced airway obstruction
    • Inhaled Particles VII
    • Siekmeier, R., C.F. Schiller-Scotland, J. Gebhart, and H. Kronenberger. 1994. Dose-dependent changes of airway resistance and aerosol pulse dispersion in cases of pharmacologically induced airway obstruction. Ann. Occup. Hyg. 38(Suppl. 1, Inhaled Particles VII):175-180.
    • (1994) Ann. Occup. Hyg. , vol.38 , Issue.1 SUPPL. , pp. 175-180
    • Siekmeier, R.1    Schiller-Scotland, C.F.2    Gebhart, J.3    Kronenberger, H.4
  • 55
    • 85035166916 scopus 로고
    • Effect of inspired oxitropiumbromide on conventional lung function and pulmonary convective gas mixing
    • Los Angeles, August 29-September 2
    • Siekmeier, R., C.F. Schiller-Scotland, J. Gebhart, and H. Kronenberger. 1994. Effect of inspired oxitropiumbromide on conventional lung function and pulmonary convective gas mixing. Presented Fourth Int. Aerosol Conf., Los Angeles, August 29-September 2, 544-545.
    • (1994) Fourth Int. Aerosol Conf. , pp. 544-545
    • Siekmeier, R.1    Schiller-Scotland, C.F.2    Gebhart, J.3    Kronenberger, H.4
  • 57
    • 0028951603 scopus 로고
    • Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema
    • Rosenthal, F.R. 1995. Aerosol deposition and dispersion characterize lung injury in a canine model of emphysema. J. Appl. Physiol. 78:1585-1595.
    • (1995) J. Appl. Physiol. , vol.78 , pp. 1585-1595
    • Rosenthal, F.R.1
  • 58
    • 0027380498 scopus 로고
    • The effect of nonuniform ventilation on the dispersion of inspired aerosol boluses - A modeling study
    • Rosenthal, F.R. 1993. The effect of nonuniform ventilation on the dispersion of inspired aerosol boluses - A modeling study. J. Aerosol Med. 6:177-197.
    • (1993) J. Aerosol Med. , vol.6 , pp. 177-197
    • Rosenthal, F.R.1
  • 59
    • 85035169987 scopus 로고
    • Mechanisms determining convective gas mixing in healthy lungs
    • Brand, P., C. Reiger, T. Beinert, and J. Heyder. 1994. Mechanisms determining convective gas mixing in healthy lungs. Eur. Respir. J. 7(Suppl. 18):333s.
    • (1994) Eur. Respir. J. , vol.7 , Issue.18 SUPPL.
    • Brand, P.1    Reiger, C.2    Beinert, T.3    Heyder, J.4
  • 60
    • 0011871447 scopus 로고
    • Intra- and inter-subject variability of pulmonary convective gas mixing determined by aerosol pulse inhalation
    • Los Angeles, August 29-September 2
    • Siekmeier, R., C.F. Schiller-Scotland, and J. Gebhart. 1994. Intra- and inter-subject variability of pulmonary convective gas mixing determined by aerosol pulse inhalation. Presented Fourth Int. Aerosol Conf., Los Angeles, August 29-September 2, 762-763.
    • (1994) Fourth Int. Aerosol Conf. , pp. 762-763
    • Siekmeier, R.1    Schiller-Scotland, C.F.2    Gebhart, J.3
  • 61
    • 0001422926 scopus 로고
    • Evaluation of tests of lung function for "screening" for early detection of chronic obstructive lung disease
    • P.T. Macklem and S. Permutt, eds. Lung Biology in Health and Disease, Marcel Dekker, New York
    • Becklake, M.R., and S. Permutt. 1979. Evaluation of tests of lung function for "screening" for early detection of chronic obstructive lung disease. In P.T. Macklem and S. Permutt, eds. The Lung in Transition between Health and Disease. Lung Biology in Health and Disease, Vol. 12. Marcel Dekker, New York, 345-387.
    • (1979) The Lung in Transition between Health and Disease , vol.12 , pp. 345-387
    • Becklake, M.R.1    Permutt, S.2
  • 62
    • 10344256422 scopus 로고
    • Influence of the oropharyngeal region on aerosol dispersion
    • Scheuch, G., Westenberger, and W. Stahlhofen. 1995. Influence of the oropharyngeal region on aerosol dispersion. J. Aerosol Med. 8:127.
    • (1995) J. Aerosol Med. , vol.8 , pp. 127
    • Scheuch, G.1    Westenberger2    Stahlhofen, W.3
  • 66
    • 0020374822 scopus 로고
    • Early diagnosis of chronic obstructive pulmonary disease
    • Black, L.F. 1982. Early diagnosis of chronic obstructive pulmonary disease. Mayo Clin. Proc. 57:765-772.
    • (1982) Mayo Clin. Proc. , vol.57 , pp. 765-772
    • Black, L.F.1
  • 67
    • 0028091157 scopus 로고
    • Outcome measures for clinical trials in cystic fibrosis. Summary of a cystic fibrosis foundation research consensus conference
    • Ramsey, B.W., and T.F. Boat. 1994. Outcome measures for clinical trials in cystic fibrosis. Summary of a cystic fibrosis foundation research consensus conference. J. Pediatr. 124: 177-192.
    • (1994) J. Pediatr. , vol.124 , pp. 177-192
    • Ramsey, B.W.1    Boat, T.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.