AT1 blockade during lactation as a model of chronic nephropathy: Mechanisms of renal injury

American Journal of Physiology - Renal Physiology

Volumn 294, Issue 6, 2008, Pages

  Machado, Flavia Gomes ^a   Poppi, Elizabete Pereira Barros ^a   Fanelli, Camilla ^a   Malheiros, Denise Maria Avancini Costa ^a   Zatz, Roberto ^a,b   Fujihara, Clarice Kazue ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Laboratorio de Fisiopatologia Renal   (Brazil)

Author keywords

Angiotensin II; Nephrogenesis

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; LOSARTAN; ANGIOTENSIN RECEPTOR ANTAGONIST;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DISEASE COURSE; GLOMERULOSCLEROSIS; GLOMERULUS FILTRATION RATE; HYPERTENSION; KIDNEY FUNCTION; KIDNEY INJURY; LACTATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; ANIMAL; CHEMICALLY INDUCED DISORDER; CHRONIC KIDNEY FAILURE; DISEASE MODEL; FEMALE; KIDNEY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; RENOVASCULAR HYPERTENSION; WISTAR RAT;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HYPERTENSION, RENAL; KIDNEY; LACTATION; LOSARTAN; PREGNANCY; RATS; RATS, WISTAR; RECEPTOR, ANGIOTENSIN, TYPE 1; RENAL INSUFFICIENCY, CHRONIC;

EID: 48249090438     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00020.2008     Document Type: Article

References (36)

1. Abbate M, Zoja C, Remuzzi G. How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17: 2974-2984, 2006.
2. Friberg P, Sundelin B, Bohman SO, Bobik A, Nilsson H, Wickman A, Gustafsson H, Petersen J, Adams MA. Renin-angiotensin system in neonatal rats: induction of a renal abnormality in response to ACE inhibition or angiotensin II antagonism. Kidney Int 45: 485-492, 1994.
3. Fujihara CK, Malheiros DMAC, Zatz R, Noronha IL. Mycophenolate mofetil attenuates renal injury in the rat remnant kidney. Kidney Int 54: 1510-1519, 1998.
4. Gandhi M, Olson JL, Meyer TW. Contribution of tubular injury to loss of remnant kidney function. Kidney Int 54: 1157-1165, 1998.
5. Gilbert JS, Lang AL, Grant AR, Nijland MJ. Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age. J Physiol 565: 137-147, 2005.
6. Goncalves AR, Fujihara CK, Mattar AL, Malheiros DMAC, Noronha IL, De Nucci G, Zatz R. Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory. Am J Physiol Renal Physiol 286: F945-F954, 2004.
7. Guron G, Adams MA, Sundelin B, Friberg P. Neonatal angiotensin-converting enzyme inhibition in the rat induces persistent abnormalities in renal function and histology. Hypertension 29: 91-97, 1997.
8. Guron G, Friberg P. An intact renin-angiotensin system is a prerequisite for normal renal development. J Hypertens 18: 123-137, 2000.
9. Guron G, Nilsson A, Nitescu N, Nielsen S, Sundelin B, Frokiaer J, Friberg P. Mechanisms of impaired urinary concentrating ability in adult rats treated neonatally with enalapril. Acta Physiol Scand 165: 103-112, 1999.
10. Hirose K, Osterby R, Nozawa M, Gundersen HJ. Development of glomerular lesions in experimental long-term diabetes in the rat. Kidney Int 21: 889-895, 1982.
11. Iosipiv IV, Schroeder M. A role for angiotensin II AT1 receptors in ureteric bud cell branching. Am J Physiol Renal Physiol 285: F199-F207, 2003.
12. Jepsen FL, Mortensen PB. Interstitial fibrosis of the renal cortex in minimal change lesion and its correlation with renal function. A quantitative study. Virchows Arch A Pathol Anat Histol 383: 265-270, 1979.
13. Krege JH, Hodgin JB, Hagaman JR, Smithies O. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension 25: 1111-1115, 1995.
14. Kriz W, Hosser H, Hahnel B, Gretz N, Provoost AP. From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: a histopathological study in rat models and human glomerulopathies. Nephrol Dial Transplant 13: 2781-2798, 1998.
15. Laemmli U. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
16. Lasaitiene D, Friberg P, Sundelin B, Chen Y. Neonatal RAS inhibition changes the phenotype of the developing thick ascending limb of Henle. Am J Physiol Renal Physiol 286: F1144-F1153, 2004.
17. Loria A, Reverte V, Salazar F, Saez F, Llinas MT, Salazar FJ. Sex and age differences of renal function in rats with reduced ANG II activity during the nephrogenic period. Am J Physiol Renal Physiol 293: F506-F510, 2007.
18. Mancini G, Carbonara AO, Heremans JF. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry 2: 235-254, 1965.
19. McCausland JE, Bertram JF, Ryan GB, Alcorn D. Glomerular number and size following chronic angiotensin II blockade in the postnatal rat. Exp Nephrol 5: 201-209, 1997.
20. Mundel P, Shankland SJ. Podocyte biology and response to injury. J Am Soc Nephrol 13: 3005-3015, 2002.
21. Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS, Ruiz P, Smithies O, Coffman TM. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest 104: 1693-1701, 1999.
22. Neuringer JR, Brenner BM. Hemodynamic theory of progressive renal disease: a 10-year update in brief review. Am J Kidney Dis 22: 98-104, 1993.
23. Ng YY, Huang TP, Yang WC, Chen ZP, Yang AH, Mu W, Nikolic-Paterson DJ, Atkins RC, Lan HY. Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats. Kidney Int 54: 864-876, 1998.
24. Nilsson AB, Nitescu N, Chen Y, Guron GS, Marcussen N, Matejka GL, Friberg P. IGF-I treatment attenuates renal abnormalities induced by neonatal ACE inhibition. Am J Physiol Regul Integr Comp Physiol 279: R1050-R1060, 2000.
25. Riser BL, Cortes P, Heilig C, Grondin J, Ladson-Wofford S, Patterson D, Narins RG. Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells. Am J Pathol 148: 1915-1923, 1996.
26. Riser BL, Cortes P, Zhao X, Bernstein J, Dumler F, Narins RG. Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat. J Clin Invest 90: 1932-1943, 1992.
27. Riser BL, Varani J, Cortes P, Yee J, Dame M, Sharba AK. Cyclic stretching of mesangial cells up-regulates intercellular adhesion molecule-1 and leukocyte adherence: a possible new mechanism for glomerulosclerosis. Am J Pathol 158: 11-17, 2001.
28. Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Suzuki Y, Mezzano S, Plaza JJ, Egido J. Role of the renin-angiotensin system in vascular diseases: expanding the field. Hypertension 38: 1382-1387, 2001.
29. Saez F, Castells MT, Zuasti A, Salazar F, Reverte V, Loria A, Salazar FJ. Sex differences in the renal changes elicited by angiotensin II blockade during the nephrogenic period. Hypertension 49: 1429-1435, 2007.
30. Schwartz MM, Lewis EJ. Focal segmental glomerular sclerosis: the cellular lesion. Kidney Int 28: 968-974, 1985.
31. Spence SG, Zacchei AG, Lee LL, Baldwin CL, Berna RA, Mattson BA, Eydelloth RS. Toxicokinetic analysis of losartan during gestation and lactation in the rat. Teratology 53: 245-252, 1996.
32. Tufro-McReddie A, Romano LM, Harris JM, Ferder L, Gomez RA. Angiotensin II regulates nephrogenesis and renal vascular development. Am J Physiol Renal Fluid Electrolyte Physiol 269: F110-F115, 1995.
33. Utimura R, Fujihara CK, Mattar AL, Malheiros DM, Noronha IL, Zatz R. Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney Int 63: 209-216, 2003.
34. Wallenstein S, Zucker CL, Fleiss JL. Some statistical methods useful in circulation research. Circ Res 47: 1-9, 1980.
35. Woods LL, Rasch R. Perinatal ANG II programs adult blood pressure, glomerular number, and renal function in rats. Am J Physiol Regul Integr Comp Physiol 275: R1593-R1599, 1998.
36. Zatz R. Haemodynamically mediated glomerular injury: the end of a 15-year-old controversy? Curr Opin Nephrol Hypertens 5: 468-475, 1996.