From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: A histopathological study in rat models and human gomerulopathies

Nephrology Dialysis Transplantation

Volumn 13, Issue 11, 1998, Pages 2781-2798

  Kriz, Wilhelm ^a   Hosser, Hiltraud ^a   Hähnel, Brunhilde ^a   Gretz, Norbert ^b   Provoost, Abraham P ^c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Chronic renal disease; Glomerulosclerosis; Interstitial fibrosis; Misdirected filtration; Renal histopathology

Indexed keywords

ADHESION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS CAPILLARY; HISTOPATHOLOGY; HYPERTENSION; KIDNEY FIBROSIS; KIDNEY TUBULE BASEMENT MEMBRANE; MALE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; AUTOPSY; BIOPSY; FIBROSIS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY GLOMERULUS; MALE; NEPHRONS; RATS;

EID: 0031756766     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/13.11.2781     Document Type: Article

References (50)

1. Rennke HG. How does glomerular epithelial cell injury contribute to progressive glomerular damage? Kidney Int 1994; [Suppl 45]: S58 S63
2. d'Agati V, Suh JI, Carbone L, Cheng JT, Appel G. Pathology of HIV-associated nephropathy: A detailed morphologic and comparative study. Kidney Int 1989; 35: 1358-1370
3. Detwiler RK, Falk RJ, Hogan SL, Jennette JC. Collapsing glomerulopathy: A clinically and pathologically distinct variant of focal segmental glomerulosclerosis. Kidney Int 1994; 45: 1416-1424
4. Valeri A, Barisoni L, Appel GB, Seigle R, d'Agati V. Idiopathic collapsing focal segmental glomerulosclerosis: a clinicopathologic study. Kidney Int 1996; 50: 1734-1746
5. Nagata M, Kriz W. Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int 1992; 42: 148-160
6. Kretzler M, Koeppen-Hagemann I, Kriz W. Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomized desoxycorticosterone rat. Virchows Arch A Path Anat Histol 1994; 425: 181-193
7. Kriz W, Hähnel B, Rösener S, Elger M. Long-term treatment of rats with FGF-2 results in focal segmental glomerulosclerosis. Kidney Int 1995; 48: 1435 1450
8. Kriz W, Hosser H, Hähnel B, Simons JL, Provoost AP. Development of vascular pole associated glomerulosclerosis in the Fawn-hooded rat. J Am Soc Nephrol 1998; 9: 381-396
9. Shirato I, Hosser H, Kimura K, Sakai T, Tomino Y, Kriz W. The development of focal segmental glomerulosclerosis in Masugi nephritis is based on progressive podocytc damage. Virchows Arch 1996; 429: 255 273
10. Bohle A, Strutz F, Müller GA. On the pathogenesis of chronic renal failure in primary glomerulopathies: A view from the interstitium. Exp Nephrol 1994; 2: 205 210
11. Schena FP, Gesualdo L, Grandaliano G, Montinaro V. Progression of renal damage in human glomerulonephritides: Is there sleight of hand in winning the game? Kidney Int 1997; 52: 1439 1457
12. Ong ACM, Fine LG. Loss of glomerular function and tubulointerstitial fibrosis: Cause or effect? Kidney Int 1994; 45: 345-351
13. Strutz F, Müller GA. The role of tubulo-interstitial processes in progression of primary renal diseases. Nephrol Dial Transplant 1994; 9: S10-S22
14. Fine LG, Ong ACM, Norman JT. Mechanisms of tubulo-interstitial injury in progression of renal diseases. Eur J Clin Invest 1993; 23: 259-265
15. D'Amico G, Ferrario F, Rastaldi MP. Tubulointerstitial damage in glomerular diseases: Its role in the progression of renal damage. Am J Kidney Dis 1995; 26: 124-132
16. Jacobson HR. Chronic renal failure:pathophysiology. Lancet 1991; 338: 419-423
17. Border WA, Noble NA. TGF-β in kidney fibrosis: A target for gene therapy. Kidney Int 1997; 51: 1388 1396
18. Kerjaschki D, Exner M, Ullrich R et al. Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis. J Clin Invest 1997; 100: 2303-2309
19. Pichler R, Giachelli CM, Lombardi D et al. Tubulointerstitial disease in glomerulonephritis: Potential role of osteopontin (uropontin). Am J Pathol 1994; 144: 915 926
20. Tang WW, Ulich TR, Lacey DL et al. Platelet-derived growth factor-BB induces renal tubulointerstitial myofibroblasts formation and tubulointerstitial fibrosis. Am J Pathol 1996; 148: 1169-1180
21. Grandaliano G, Gesualdo L, Ranieri E et al. Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: A pathogenetic role in interstitial monocytes recruitment. J Am Soc Nephrol 1996; 7: 906 913
22. Ketteler M, Noble NA, Border WA. Transforming growth factor-and the kidney. J Nephrol 1995; 8: 143-147
23. Johnson RJ, Schreiner GF. Hypothesis: The role of acquired tubulointerstitial disease in the pathogenesis of salt-dependent hypertension. Kidney Int 1997; 52: 1169-1179
24. Giachelli CM, Pichler R, Lombardi D et al. Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis. Kidney Int 1994; 45: 515-524
25. Wu LL, Cox A, Roe CJ, Dziadck M, Cooper ME, Gilbert RE. Transforming growth factor 1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system. Kidney Int 1997; 51: 1553-1567
26. Bohle A, Gise HV, Mackensen-Haen S, Stark-Jakob B. The obliteration of the postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Klin Wochenschr 1981; 59: 1043-1051
27. Egido J. Vasoactive hormones and renal sclerosis. Kidney Int 1996; 49: 578 597
28. Remuzzi G, Ruggenenti P, Benigni A. Understanding the nature of renal disease progression. Kidney Int 1997; 51: 2-15
29. Burton C, Harris KPG. The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 1996; 27: 765-775
30. Rubin-Kelly VE, Jevnikar AM. Antigen presentation by renal tubular epithelial cells. J Am Soc Nephrol 1991; 2: 13-26
31. Floege J, Hackmann B, Kliem V et al. Age-related glomerulosclerosis and interstital fibrosis in Milan normotensive rats: a podocyte disease. Kidney Int 1997; 51: 230-243
32. Deppe M. Altersabhängige morphologische Veränderungen der Glomeruli bei Mailänder Ratten. Diplomarbeit Biologie, Medizinische Hochschule Hannover, 1983
33. Marcussen N. Biology of disease: Atubular glomeruli and structural basis for chronic renal failure. Lab Invest 1992; 66: 265-284
34. Marcussen N, Christensen S, Petersen JS, Shalmi M. Atubular glomeruli, renal function and hypertrophic response in rats with chronic lithium nephropathy. Virchows Arch 1991; 419: 281 289
35. Marcussen N. Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. An experimental stereological investigation. APMIS 1990; 98: 1087 1097
36. Marcussen N, Jacobsen NO. The progression of cisplatin-induced tubulointerstitial nephropathy in rats. APMIS 1992; 100: 256 268
37. Marcussen N. Atubular glomeruli in renal artery stenosis. Lab Invest 1991; 65: 558-565
38. Scherberich JE, Wolf G, Albers C, Nowack A, Stuckhardt C, Schoeppe W. Glomerular and tubular membrane antigens reflecting cellular adaptation in human renal failure. Kidney Int 1989; 36: 38-51
39. Elema JD, Arends A. Focal and segmental glomerular hyalinosis and sclerosis in the rat. Lab Invest 1975; 33: 554-561
40. Grond J, Schilthuis MS, Koudstaal J, Elema JD. Mesangial function and glomerular sclerosis in rats afte UNX. Kidney Int 1982; 22: 338-343
41. El Nahas AM. Glomerular sclerosis: from rat to man. Renal Failure 1993; 15: 385-388
42. Risdon RA, Sloper JC, de Wardener HE. Relationship between renal function and histologic changes found in renal-biopsy specimens from patients with persistent glomerular nephritis. Lancet 1968; 2: 363 366
43. Bohle A, Glomb D, Grund KE, Mackensen S. Correlations between relative interstitial volume of the renal cortex and serum creatinine concentration in minimal changes with nephrotic syndrome and in focal sclerosing glomerulonephritis. Virchows Arch A Path Anat Histol 1977; 376: 221-232
44. Wehrmann M, Bohle A, Bogenschütz O et al. Long-term prognosis of chronic idiopathic membranous glomerulonephritis. An analysis of 334 cases with particular regard to tubulo-interstitial changes. Clin Nephrol 1989; 31: 67 76
45. Schainuck LI, Striker GE, Cutler RE, Benditt EP. Structural-functional correlations in renal disease. Part II: The correlations. Hum Pathol 1970; 1: 631-641
46. Yee J, Kuncio GS, Neilson EG. Tubulointerstitial injury following glomerulonephritis. Semin Nephrol 1991; 11: 361 366
47. Kaplan C, Pasternack B, Shah H, Gallo G. Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 1975; 80: 227-234
48. McLachlan MS, Guthrie JC, Anderson CK, Fulker MJ. Vascular and glomerular changes in the ageing kidney. J Pathol 1977; 121 (2): 65-78
49. Chan KW, Leung CY, Chan CW. Age-related glomerular sclerosis: baseline values in Hong Kong. Pathology 1990; 22: 177-180
50. Nyengaard JR, Bendtsen TF. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec 1992; 232: 194-201