A simple one-step protocol for preparing small-sized doxorubicin-loaded liposomes

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 27, Issue 3, 2008, Pages 181-189

  Sonar, Shailesh ^a   D'Souza, Sandra E ^a   Mishra, Kaushala Prasad ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Cancer therapy; Doxorubicin encapsulation; Ethanol injection method; Factors affecting size; Liposomes; SCOL

Indexed keywords

ALCOHOL; DOXORUBICIN; LIPID; LIPOSOME; PHOSPHOLIPID;

ARTICLE; DRUG DELIVERY SYSTEM; ENCAPSULATION; INJECTION; LIPID COMPOSITION; PARAMETER; PRIORITY JOURNAL;

EID: 48149107716     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: 10.1615/JEnvironPatholToxicolOncol.v27.i3.20     Document Type: Article

References (20)

1. Ahl PL, Bhatia SK, Meers P, Roberts P, Stevens R, Dause R, Perkins WR, Janoff AS. Enhancement of the in vivo circulation lifetime of L-a-distearoylphosphatidylcholine liposomes: importance of liposomal aggregation versus complement opsonization. Biochim Biophys Acta. 1997;1329:370-82.
2. Hobbs SK, Monsky WL, Yuan F, Roberts WG, Griffith L, Torchilin VP, Jain RK. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci USA. 1998;95:4607-12.
3. Nakhla, T, Marek M, Kovalcik T. Issues associated with large-scale production of liposomal formulations, Drug Delivery Technology. http://www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=53.
4. Batzri S, Korn ED. Single bilayer liposomes prepared without sonication,. Biochim Biophys Acta. 1973;298:1015-9.
5. Forssen, EA, Tokes ZA. In vitro and in vivo studies with adriamycin liposomes. Biochem Biophys Res Commun. 1979;91:1295-8.
6. Andresen TL, Jensen SS, Jorgensen K. Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release. Prog in Lipid Res. 2005;44:68-97.
7. Working PK, Newman MS, Huang SK, Mayhew E, Vaage J, Lasic. D. Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth® liposomes (Doxil). J Liposome Res. 1994;4:667-87.
8. Mayer LD, Bally MB, Cullis PR. Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient. Biochim Biophys Acta. 1986;857:123-6.
9. Chiu GNC, Abraham SA, Ickenstein LM, Karlsson G, Edwards K, Wasan EK, Bally MB. Encapsulation of doxorubicin into thermosensitive liposomes via comlpexation with the transition metal manganese. J Controlled Rel. 2005;104:271-88.
10. Abraham SA, Edwards K, Karlsson G, MacIntosh S, Mayer LD, McKenzie C, Bally MB. Formation of transition metal-doxorubicin complexes inside liposomes. Biochim Biophys Acta. 2002;1565:41-54.
11. Shabbits JA, Chiu GNC, Mayer LD. Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems. J Controlled Rel. 2002;84:161-70.
12. Stewart JCM. Colorimetric determination of phospholipids with ferrothiocyanate. Anal Biochem. 1980;104:10-4.
13. Abraham SA, Waterhouse DN, Mayer LD, Cullis PR, Madden TD, Bally MB. The liposomal formulation of doxorubicin, Methods Enzymol. 2005;391:71-96.
14. Wang JP, Maitani Y, Takayama K, Nagai T. Pharmacokinetics and antitumor effect of doxorubicin carried by stealth and remote loading proliposome. Pharm Res. 2000;17:782-7.
15. Domazou AS, Luigi PL, Size distribution of spontaneously formed liposomes by the alcohol injection method. J Liposome Res. 2002;12:205-20.
16. Edgerly-Plug, Laura M. Method of controlling the size of liposomes, U.S. Patent 6,596,305, 2003.
17. El Maghraby GMM, Williams AC, Barry BW. Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes. Int J Pharmaceutics. 2004;276:143-61.
18. McIntosh TJ. The effect of cholesterol on the structure of phosphatidylcholine bilayers. Biochim Biophys Acta. 1978;513:43-58.
19. Wagner A, Vorauer-Uhl K, Kreismayr G, Katinger H. The crossflow injection technique: An improvement of the ethanol injection method. J Liposome Res. 2002;12:259-70.
20. Wagner A, Vorauer-Uhl K, Katinger H. Liposomes produced in a pilot scale: production, purification and efficiency aspects. Eur J Pharm Biopharm. 2002;54:213-9.