Proinsulin C-peptide stimulates a PKC/IκB/NF-κB signaling pathway to activate COX-2 gene transcription in Swiss 3T3 fibroblasts

Journal of Biochemistry

Volumn 139, Issue 6, 2006, Pages 1083-1088

  Kitazawa, Masashi ^a   Shibata, Yasutaka ^b   Hashimoto, Seiichi ^b   Ohizumi, Yasushi ^a,c   Yamakuni, Tohru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b ASTELLAS PHARMA INC   (Japan)

^c YOKOHAMA COLLEGE OF PHARMACY   (Japan)

Author keywords

C peptide; Cyclooxygenase 2; Diabetes; NF B dependent transcription; PKC

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; C PEPTIDE; CYCLOOXYGENASE 2; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME INHIBITION; FIBROBLAST; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; BLOTTING, WESTERN; C-PEPTIDE; CARBAZOLES; CYCLOOXYGENASE 2; FIBROBLASTS; I-KAPPA B PROTEINS; INDOLES; LUCIFERASES; MALEIMIDES; MICE; NF-KAPPA B; NITRILES; PHOSPHORYLATION; PLASMIDS; PROINSULIN; PROMOTER REGIONS (GENETICS); PROTEIN KINASE C; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SULFONES; SWISS 3T3 CELLS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 33746885152     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/jb/mvj122     Document Type: Article

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