Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism

Psychoneuroendocrinology

Volumn 33, Issue 7, 2008, Pages 951-963

  Ashcraft, Kathleen A ^a   Hunzeker, John ^a   Bonneau, Robert H ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

CD8+ T lymphocytes; Glucocorticoids; HSV 1; Mucosal immunity; Stress

Indexed keywords

CORTICOSTERONE; GLUCOCORTICOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CERVICAL LYMPH NODE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENCEPHALITIS; HERPES SIMPLEX VIRUS 1; LYMPHOCYTE COUNT; LYMPHOID TISSUE; MALE; MEDIASTINUM LYMPH NODE; MENTAL STRESS; MOUSE; NONHUMAN; NOSE CAVITY; PATHOGENICITY; PRIORITY JOURNAL; VIRUS REPLICATION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CORTICOSTERONE; DOWN-REGULATION; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HORMONE ANTAGONISTS; IMMUNITY, MUCOSAL; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; MIFEPRISTONE; RECEPTORS, GLUCOCORTICOID; STRESS, PSYCHOLOGICAL;

EID: 48149103528     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2008.04.010     Document Type: Article

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