Upper respiratory tract resistance to influenza infection is not prevented by the absence of either nasal-associated lymphoid tissue or cervical lymph nodes

Journal of Immunology

Volumn 175, Issue 5, 2005, Pages 3186-3196

  Wiley, James A ^a   Tighe, Michael P ^b   Harmsen, Allen G ^a  

^a MONTANA STATE UNIVERSITY   (United States)

^b TRUDEAU INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CERVICAL LYMPH NODE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; INFLUENZA; LYMPHOID TISSUE; MALE; MOUSE; NONHUMAN; NOSE MUCOSA; PRIORITY JOURNAL; UPPER RESPIRATORY TRACT INFECTION;

EID: 23844549266     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.5.3186     Document Type: Article

References (21)

1. Zuercher, A. W., S. E. Coffin, M. C. Thurnheer, P. Fundova, and J. J. Cebra. 2002. Nasal-associated lymphoid tissue is a mucosal inductive site for viral-specific humoral and cellular immune responses. J. Immunol. 168: 1796-1803.
2. + T cells persist in the upper respiratory tract following influenza virus infection. J. Immunol. 167: 3292-3299.
3. Wu, H.-Y., S. Abdu, D. Stinson, and M. W. Russell. 2000. Generation of female genital tract antibody responses by local or central (common) mucosal immunization. Inf. Immunity 68: 5539-5545.
4. Yao, Q., V. Vuong, M. Li, and D. W. Compans. 2002. Intranasal immunization with SIV virus-like particles (VLPs) elicits systemic and mucosal immunity. Vaccine 20: 2537-2545.
5. Velge-Roussel, F., P. Marcelo, A. C. Lepage, D. Buzoni-Gatel, and D. T. Bout. 2000, Intranasal immunization with Toxoplasma gondii SAG1 induces protective cells into both NALT and GALT compartments. Infect. Immun. 68: 969-972.
6. Perry, M., and A. Whyte. 1998. Immunology of the tonsils. Immun. Today 19: 414-421.
7. Wolvers, D. A. W., C. J. J. C.-d. Roo, R. E. Mebius, M. J. F. v. d. Cammen, F. Tirion, A. M. M. Miltenburg, and G. Kraal. 1999. Intranasal induced immunological tolerance is determined by characteristics of the draining lymph nodes: studies with OVA and human cartilage gp-39. J. Immunol. 162: 1994-1998.
8. Harmsen, A., K. Kusser, L. Hartson, M. Tighe, M. J. Sunshine, J. D. Sedgwick, Y. Choi, D. R. Littman, and T. D. Randall. 2002. Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-α (LTα) and retinoic acid receptor-related orphan receptor-α, but the organization of NALT is LTα dependent. J. Immunol. 168: 986-990.
9. Lund, F. E., S. Partida-Sanchez, B. O. Lee, K. L. Kusser, L. Hartson, R. J. Hogan, D. L. Woodland, and T. D. Randall. 2002. Lymphotoxin-α-deficient mice make delayed, but effective, T and B cell responses to influenza. J. Immunol. 169: 5236-5243.
10. Banks, T., B. Rouse, M. Kerley, P. Blair, V. Godfrey, N. Kuklin, D. Bouley, J. Thomas, S. Kanangat, and M. Mucenski. 1995. Lymphotoxin-α- deficient mice: effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155: 1685-1693.
11. Popesko, P., V. Rajtova, and J. Horak. 1992. Mouse. In A Colour Atlas of Anatomy of Small Laboratory Animals. English Translation Vol. 2. Wolf, London, pp. 105-166.
12. + T cells in primary and secondary influenza pneumonia. Immunity 8: 683-691.
13. Wiley, J. A., A. Cerwenka, J. R. Harkema, R. W. Dutton, and A. G. Harmsen. 2001. Production of IFNγ by influenza HA-specific CD8 effector T cells influences the development of pulmonary immunopathology. Am. J. Pathol. 158: 119-130.
14. Renegar, K. B., P. A. Small, L. G. Boykins, and P. F. Wright. 2004. Role of TgA versus TgG in the control of influenza viral infection in the murine respiratory tract. J. Immunol. 173: 1978-1986.
15. Wu, H.-Y., E. B. Nikolova, K. W. Beagley, J. H. Eldridge, and M. W. Russell. 1997. Development of antibody-secreting cells and antigen-specific T cells in cervical lymph nodes after intranasal immunization. Infect. Immun. 65: 227-235.
16. Kris, R., RA Yetter, R Cogliano, R Ramphal, PA Small. 1988. Passive serum antibody causes temporary recovery from influenza virus infection of the nose, trachae and lung of nude mice. Immunology 63: 349-353.
17. Tamura, S., T. Iwasaki, A. H. Thompson, H. Asanuma, Z. Chen, Y. Suzuki, C. Aizawa, and T. Kurata. 1998. Antibody-forming cells in the nasal-associated lymphoid tissue during primary influenza virus infection. J. Gen. Virol. 79: 291-299.
18. + cytotoxic T lymphocyte responses induced in mucosa-associated tissues. Virology 254: 50-60.
19. Gallichan, W. S., and K. L. Rosenthal. 1996. Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization. J. Exp. Med. 184: 1879-1890.
20. Masopust, D., J. Jiang, H. Shen, and L. Lefrancois. 2001. Direct analysis of the dynamics of the intestinal mucosa CD8 T cell response to systemic virus infection. J. Immunol. 166: 2348-2356.
21. Wu, Y., X. Wang, K. L. Csencsits, A. Haddad, N. Walters, and D. W. Pascual. 2001. M cell-targeted DNA vaccination. Proc. Natl. Acad. Sci. USA 98: 9318-9323.