The LDL receptor-related protein can form homo-dimers in neuronal cells

Neuroscience Letters

Volumn 442, Issue 2, 2008, Pages 91-95

  Makarova, Alexandra ^a   Bercury, Kathryn K ^a   Adams, Kenneth W ^a   Joyner, Daniel ^a   Deng, Meihua ^a   Spoelgen, Robert ^a   Koker, Mirjam ^a   Strickland, Dudley K ^b   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Dimer; Homo dimerization; Low density lipoprotein receptor related protein; LRP

Indexed keywords

HOMODIMER; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

ANIMAL CELL; ARTICLE; DIMERIZATION; ENDOCYTOSIS; FLUORESCENCE; GENETIC COMPLEMENTATION; GLIOMA; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGHT CHAIN; MICROSCOPY; NERVE CELL; NERVE CELL CULTURE; NEUROBLASTOMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO, MAMMALIAN; ENDOCYTOSIS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GREEN FLUORESCENT PROTEINS; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; MICE; NEURONS; PROTEIN PROCESSING, POST-TRANSLATIONAL; SEQUENCE HOMOLOGY, AMINO ACID; TRANSFECTION;

EID: 48149099238     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.06.070     Document Type: Article

References (26)

1. S. Fedoroff, A. Richardson, Protocols For Neural Cell Culture, 3rd ed., Human Press, 2001.
2. Alvarez E., Girones N., and Davis R.J. Intermolecular disulfide bonds are not required for the expression of the dimeric state and functional activity of the transferrin receptor. EMBO J. 8 (1989) 2231-2240
3. Bacskai B.J., Skoch J., Hickey G.A., Allen R., and Hyman B.T. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. J. Biomed. Opt. 8 (2003) 368-375
4. Bacskai B.J., Xia M.Q., Strickland D.K., Rebeck G.W., and Hyman B.T. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-d-aspartate receptors. Proc. Natl. Acad. Sci. USA 97 (2000) 11551-11556
5. Barnes H., Larsen B., Tyers M., and van Der Geer P. Tyrosine-phosphorylated low density lipoprotein receptor-related protein 1 (Lrp1) associates with the adaptor protein SHC in SRC-transformed cells. J. Biol. Chem. 276 (2001) 19119-19125
6. Chen C.D., Oh S.Y., Hinman J.D., and Abraham C.R. Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. J. Neurochem. 97 (2006) 30-43
7. Conner S.D., and Schmid S.L. Differential requirements for AP-2 in clathrin-mediated endocytosis. J. Cell Biol. 162 (2003) 773-779
8. Gotthardt M., Trommsdorff M., Nevitt M.F., Shelton J., Richardson J.A., Stockinger W., Nimpf J., and Herz J. Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J. Biol. Chem. 275 (2000) 25616-25624
9. Herz J., and Strickland D.K. LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest. 108 (2001) 779-784
10. Jares-Erijman E.A., and Jovin T.M. FRET imaging. Nat. Biotechnol. 21 (2003) 1387-1395
11. Kerppola T.K. Visualization of molecular interactions by fluorescence complementation. Nat. Rev. Mol. Cell Biol. 7 (2006) 449-456
12. Kinoshita A., Shah T., Tangredi M.M., Strickland D.K., and Hyman B.T. The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65. J. Biol. Chem. 278 (2003) 41182-41188
13. Kowal R.C., Herz J., Goldstein J.L., Esser V., and Brown M.S. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins. Proc. Natl. Acad. Sci. USA 86 (1989) 5810-5814
14. Lillis A.P., Mikhailenko I., and Strickland D.K. Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. J. Thromb. Haemost. 3 (2005) 1884-1893
15. Loukinova E., Ranganathan S., Kuznetsov S., Gorlatova N., Migliorini M.M., Loukinov D., Ulery P.G., Mikhailenko I., Lawrence D.A., and Strickland D.K. Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF. J. Biol. Chem. 277 (2002) 15499-15506
16. Matsunaga S., Xie Q., Kumano M., Niimi S., Sekizawa K., Sakakibara Y., Komba S., and Machida S. Lectin-like oxidized low-density lipoprotein receptor (LOX-1) functions as an oligomer and oligomerization is dependent on receptor density. Exp. Cell Res. 313 (2007) 1203-1214
17. May P., Reddy Y.K., and Herz J. Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain. J. Biol. Chem. 277 (2002) 18736-18743
18. Outeiro T.F., Putcha P., Tetzlaff J.E., Spoelgen R., Koker M., Carvalho F., Hyman B.T., and McLean P.J. Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS ONE 3 (2008) e1867
19. Peltan I.D., Thomas A.V., Mikhailenko I., Strickland D.K., Hyman B.T., and von Arnim C.A. Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons. Biochem. Biophys. Res. Commun. 349 (2006) 24-30
20. Qiu Z., Strickland D.K., Hyman B.T., and Rebeck G.W. alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-d-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons. J. Biol. Chem. 277 (2002) 14458-14466
21. Robenek H., Harrach B., and Severs N.J. Display of low density lipoprotein receptors is clustered, not dispersed, in fibroblast and hepatocyte plasma membranes. Arterioscler. Thromb. 11 (1991) 261-271
22. Scheuermann S., Hambsch B., Hesse L., Stumm J., Schmidt C., Beher D., Bayer T.A., Beyreuther K., and Multhaup G. Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J. Biol. Chem. 276 (2001) 33923-33929
23. Strasser V., Fasching D., Hauser C., Mayer H., Bock H.H., Hiesberger T., Herz J., Weeber E.J., Sweatt J.D., Pramatarova A., Howell B., Schneider W.J., and Nimpf J. Receptor clustering is involved in Reelin signaling. Mol. Cell Biol. 24 (2004) 1378-1386
24. Su H.P., Brugnera E., Van Criekinge W., Smits E., Hengartner M., Bogaert T., and Ravichandran K.S. Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cells. J. Biol. Chem. 275 (2000) 9542-9549
25. Su H.P., Nakada-Tsukui K., Tosello-Trampont A.C., Li Y., Bu G., Henson P.M., and Ravichandran K.S. Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J. Biol. Chem. 277 (2002) 11772-11779
26. van Driel I.R., Davis C.G., Goldstein J.L., and Brown M.S. Self-association of the low density lipoprotein receptor mediated by the cytoplasmic domain. J. Biol. Chem. 262 (1987) 16127-16134