The endometrial effects of isoflavones: A discussion paper

Complementary Therapies in Clinical Practice

Volumn 14, Issue 3, 2008, Pages 212-214

  Messina, Mark ^a  

^a NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 48049113938     PISSN: 17443881     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ctcp.2008.04.005     Document Type: Note

References (19)

1. Chandrareddy A., Muneyyirci-Delale O., McFarlane S.I., and Murad O.M. Adverse effects of phytoestrogens on reproductive health: a report of three cases. Complement Ther Clin Pract 14 2 (2008) 132-135
2. Lethaby A., Brown J., Marjoribanks J., Kronenberg F., Roberts H., and Eden J. Phytoestrogens for vasomotor menopausal symptoms. Cochrane Database Syst Rev 4 (2007) CD001395
3. Cheng G., Wilczek B., Warner M., Gustafsson J.A., and Landgren B.M. Isoflavone treatment for acute menopausal symptoms. Menopause 14 3 Part 1 (2007) 468-473
4. Nahas E.A., Nahas-Neto J., Orsatti F.L., Carvalho E.P., Oliveira M.L., and Dias R. Efficacy and safety of a soy isoflavone extract in postmenopausal women: a randomized, double-blind, and placebo-controlled study. Maturitas 58 3 (2007) 249-258
5. D'Anna R., Cannata M.L., Atteritano M., Cancellieri F., Corrado F., Baviera G., et al. Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo-controlled study. Menopause 14 4 (2007) 648-655
6. Messina M., Nagata C., and Wu A.H. Estimated Asian adult soy protein and isoflavone intakes. Nutr Cancer 55 1 (2006) 1-12
7. Setchell K.D., Brown N.M., Desai P., Zimmer-Nechemias L., Wolfe B.E., Brashear W.T., et al. Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements. J Nutr 131 4 (2001) 1362S-1375S
8. Chua R., Anderson K., Chen J., and Hu M. Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products. J Altern Complement Med 10 6 (2004) 1053-1060
9. Wolff L.P., Martins M.R., Bedone A.J., and Monteiro I.M. Endometrial evaluation in menopausal women after six months of isoflavones. Rev Assoc Med Bras 52 6 (2006) 419-423
10. Newbold R.R., Banks E.P., Bullock B., and Jefferson W.N. Uterine adenocarcinoma in mice treated neonatally with genistein. Cancer Res 61 11 (2001) 4325-4328
11. Murray M.J., Meyer W.R., Lessey B.A., Oi R.H., DeWire R.E., and Fritz M.A. Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: a pilot trial. Menopause 10 5 (2003) 456-464
12. Lian Z., Niwa K., Tagami K., Hashimoto M., Gao J., Yokoyama Y., et al. Preventive effects of isoflavones, genistein and daidzein, on estradiol-17beta-related endometrial carcinogenesis in mice. Jpn J Cancer Res 92 7 (2001) 726-734
13. Yavuz E., Oktem M., Esinler I., Toru S.A., and Zeyneloglu H.B. Genistein causes regression of endometriotic implants in the rat model. Fertil Steril 88 Suppl 4 (2007) 1129-1134
14. Xu W.H., Zheng W., Xiang Y.B., Ruan Z.X., Cheng J.R., Dai Q., et al. Soya food intake and risk of endometrial cancer among Chinese women in Shanghai: population based case-control study. Br Med J 328 7451 (2004) 1285-1290
15. Goodman M.T., Wilkens L.R., Hankin J.H., Lyu L.C., Wu A.H., and Kolonel L.N. Association of soy and fiber consumption with the risk of endometrial cancer. Am J Epidemiol 146 4 (1997) 294-306
16. Unfer V., Casini M.L., Costabile L., Mignosa M., Gerli S., and Di Renzo G.C. Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study. Fertil Steril 82 1 (2004) 145-148
17. Foth D., and Nawroth F. Effect of phytoestrogens on the endometrium?. Fertil Steril 83 1 (2005) 256-257 author reply 7
18. National Toxicology Program UDoHaHS, Center for the Evaluation of Risks to Human Reproduction. NTP-CERHR expert panel report on the reproductive and developmental toxicity of soy formula. 〈http://cerhrniehsnihgov〉 2006.
19. Marini H., Minutoli L., Polito F., Bitto A., Altavilla D., Atteritano M., et al. Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a randomized trial. Ann Intern Med 146 12 (2007) 839-847