Metformin, B12 and homocysteine levels: The plausible cause or effect?

Journal of the Formosan Medical Association

Volumn 107, Issue 6, 2008, Pages 505-506

  Musarrat, Kashif ^a   Kalathil, Dhanya ^a   Varughese, George I ^a  

^a QUEEN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYANOCOBALAMIN; HOMOCYSTEINE; METFORMIN; ROSIGLITAZONE;

AMINO ACID BLOOD LEVEL; CLINICAL TRIAL; CYANOCOBALAMIN DEFICIENCY; DEEP VEIN THROMBOSIS; DIABETES MELLITUS; DIETARY INTAKE; EVIDENCE BASED MEDICINE; GENE MUTATION; HUMAN; HYPERHOMOCYSTEINEMIA; LETTER; OVARY POLYCYSTIC DISEASE; SIDE EFFECT;

EID: 48049091798     PISSN: 09296646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0929-6646(08)60160-6     Document Type: Letter

References (9)

1. Lin HY, Chung CY Chang CS, et al. Hyperhomocysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient. J Formos Med Assoc 2007;106:774-8.
2. Carlsen SM, Kjøtrød S, Vanky E, et al. Homocysteine levels are unaffected by metformin treatment in both nonpregnant and pregnant women with polycystic ovary syndrome. Acta Obstet Gynecol Scand 2007;86:145-50.
3. Pongchaidecha M, Srikusalanukul V, Chattananon A, et al. Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: a cross-sectional study in patients with type 2 diabetes meilitus. J Med Assoc Thai 2004;87:780-7.
4. Diakoumopoulou E, Tentolouris N, Kirlaki E, et al. Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors. Nutr Metab Cardiovasc Dis 2005;15:109-17.
5. Wulffelé MG, Kooy A, Lehert P, et al. Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med 2003;254:455-63.
6. Hoogeveen EK, Kostense PJ, Jakobs C, et al. Does metformin increase the serum total homocysteine level in non-insulin-dependent diabetes mellitus? J Intern Med 1997;242:389-94.
7. Sahin M, Tutuncu NB, Ertugrul D, et al. Effects of metformin or rosiglitazone on serum concentrations of homocysteine, folate, and vitamin B12 in patients with type 2 diabetes mellitus. J Diabetes Complications 2007;21:118-23.
8. Varughese GI, Scarpello JH. Metformin and vitamin B12 deficiency: the role of H2 receptor antagonists and proton pump inhibitors. Age Ageing 2007;36:110-1.
9. Varughese GI, Tahrani AA, Scarpello JH. The long and short of metformin-related vitamin B12 deficiency. Arch Intern Med 2007;167:729-30.