Hyperhomacysteinemia, deep vein thrombosis and vitamin B12 deficiency in a metformin-treated diabetic patient

Journal of the Formosan Medical Association

Volumn 106, Issue 9, 2007, Pages 774-778

  Lin, Hsuan Yu ^a   Chung, Chih Yuan ^a   Chang, Cheng Shyong ^a   Wang, Ming Lun ^a   Lin, Jen Shiou ^a   Shen, Ming Ching ^a,b  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Diabetes mellitus; Hyperhomocysteinemia; Metformin; Venous thrombosis

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ANTICOAGULANT AGENT; CYANOCOBALAMIN; GLIBENCLAMIDE; INSULIN; METFORMIN; ANTIDIABETIC AGENT;

AGED; ARTICLE; CASE REPORT; CLINICAL FEATURE; CYANOCOBALAMIN DEFICIENCY; DEEP VEIN THROMBOSIS; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GENE MUTATION; HOMOZYGOSITY; HUMAN; HYPERHOMOCYSTEINEMIA; LABORATORY TEST; MEGALOBLASTIC ANEMIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PHLEBOGRAPHY; PHYSICAL EXAMINATION; SHORT COURSE THERAPY; VITAMIN SUPPLEMENTATION; CHEMICALLY INDUCED DISORDER; VEIN THROMBOSIS;

AGED; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPERHOMOCYSTEINEMIA; HYPOGLYCEMIC AGENTS; METFORMIN; VENOUS THROMBOSIS; VITAMIN B 12 DEFICIENCY;

EID: 35348910882     PISSN: 09296646     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0929-6646(08)60039-X     Document Type: Article

References (20)

1. Undas A, Brozek J, Szczeklik A. Homocysteine and thrombosis: from basic science to clinical evidence. Thromb Haemost 2005;94:907-15.
2. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995; 10:111-3.
3. Refsum H, Smith AD, Ueland PM, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 2004;50:3-32.
4. Callaghan TS, Hadden DR, Tomkin GH. Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment. Br Med J 1980;280: 1214-5.
5. Gilligan MA. Metformin and vitamin B12 deficiency. Arch Intern Med 2002;162:484-5.
6. Rosendaal FR. Venous thrombosis: the role of genes, environment, and behavior. Hematology Am Soc Hematol Educ Program 2005;1-12.
7. Shen MC, Lin JS, Tsai W. High prevalence of antithrombin III, protein C and protein S deficiency, but no factor V Leiden mutation in venous thrombophilic Chinese patients in Taiwan. Thromb Res 1997;87:377-85.
8. Lin JS, Shen MC, Tsai W. The mutation at position 20210 in the 3′-untranslated region of the prothrombin gene is extremely rare in Taiwanese Chinese patients with venous thrombophilia. Thromb Haemost 1998;80:343.
9. Lin JS, Shen MC, Cheng WC, et al. Age, sex and vitamin status affect plasma level of homocysteine, but hyperhomocysteinaemia is possibly not an important risk factor for venous thrombophilia in Taiwanese Chinese. Br J Haematol 2002;117:159-63.
10. Frederiksen J, Juul K, Grande P, et al. Methylenetetrahydrofolate reductase polymorphism (C677T), hyperhomocysteinemia, and risk of ischemic cardiovascular disease and venous thromboembolism: prospective and case-control studies from the Copenhagen City Heart Study. Blood 2004;10:3046-51.
11. den Heijer M, Rosendaal FR, Blom HJ, et al. Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 1998;80:874-7.
12. Wald SW, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002;325:1202-6.
13. Lin JS, Shen MC, Tsai W, et al. The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese. Thromb Res 2000;97:89-94.
14. Tomkin GH, Hadden DR, Weaver JA, et al. Vitamin B12 status of patients on long-term metformin therapy. Br Med J 1971;2:685-7.
15. Schafer G. Some new aspects on the interaction of hypolycemia-producing biguanides with biological membranes. Biochem Pharmacol 1976;25:2015-24.
16. Carmel R, Rosenberg AH, Lau KS, et al. Vitamin B12 uptake by human small bowel homogenate and its enhancement by intrinsic factor. Gastroenterology 1969;56: 548-55.
17. Bauman WA, Shaw S, Javatilleke F, et al. Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin. Diabetes Care 2000;23:1227-31.
18. Caspary WF, Zavada I, Reimold W, et al. Alteration of bile acid metabolism and vitamin B12 absorption in diabetics on biguanides. Diabetologia 1977;3:187-93.
19. Filioussi K, Bonovas S, Katsaros T. Should we screen diabetic patients using biguanides for megaloblastic anaemia? Aust Fam Physician 2003;32:383-4.
20. Creager MA, Luscher TF, Cosentino F, et al. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy. Circulation 2003;108:1527-32.