Molecular clock debate: Time dependency of molecular rate estimates for mtDNA: This is not the time for wishful thinking

Heredity

Volumn 101, Issue 2, 2008, Pages 107-108

  Howell, N ^a,b   Howell, C ^a   Elson, J L ^c  

^a Matrilinex LLC   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

GENETIC SELECTION; GENETICS; HUMAN; MEDICAL GENETICS; MOLECULAR EVOLUTION; NOTE; PEDIGREE;

DNA, MITOCHONDRIAL; EVOLUTION, MOLECULAR; GENETICS, MEDICAL; HUMANS; PEDIGREE; SELECTION (GENETICS);

EID: 47949127353     PISSN: 0018067X     EISSN: 13652540     Source Type: Journal    
DOI: 10.1038/hdy.2008.52     Document Type: Note

References (11)

1. Bandelt H-J (2008). Time dependency of molecular rate estimates: tempest in a teacup. Heredity 100: 1-2.
2. Burridge CP, Craw D, Fletcher D, Waters JM (2008). Geological dates and molecular rates: fish DNA sheds light on time dependency. Mol Biol Evol 25: 624-633.
3. Cree LM, Samuels DC, De Sousa Lopes SC, Rajasimha HK, Wonnapinij P, Mann JR et al. (2008). A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes. Nat Genet 40: 249-254.
4. Elson JL, Turnbull DM, Howell N (2004). Comparative genomics and the evolution of human mitochondrial DNA: assessing the effects of selection. Am J Hum Genet 74: 229-238.
5. Ho SYW, Shapiro B, Phillips M, Cooper A, Drummond AJ (2007). Evidence for time dependency of molecular rate estimates. Syst Biol 56: 515-522.
6. Howell N, Elson JL, Howell C, Turnbull DM (2007). Relative rates of evolution in the coding and control regions of African mtDNAs. Mol Biol Evol 24: 2213-2221.
7. Howell N, Smejkal CB, Mackey DA, Chinnery PF, Turnbull DM, Herrnstadt C (2003). The pedigree rate of sequence divergence in the human mitochondrial genome. There is a difference between phylogenetic and pedigree rates. Am J Hum Genet 72: 659-670.
8. Kivisild T, Shen P, Wall DP, Do B, Sung R, Davis K et al. (2006). The role of selection in the evolution of human mitochondrial genomes. Genetics 172: 373-387.
9. Pulquério MJF, Nichols RA (2007). Dates from the molecular clock: how wrong can we be? Trends Ecol Evol 22: 180-184.
10. Stewart JB, Freyer C, Elson JE, Wredenberg A, Cansu Z, Trifunovic A et al. (2008). Strong purifying selection in transmission of mammalian mitochondrial DNA. PLoS Biol 6: e10.
11. Zhivotovsky LA, Underhill PA, Feldman MW (2006). Difference between evolutionarily effective and germ line mutation rate due to stochastically varying haplogroup size. Mol Biol Evol 23: 2268-2270.