메뉴 건너뛰기




Volumn 18, Issue 3, 2008, Pages 401-413

The Molecular Biology of Gastrointestinal Cancer: Implications for Diagnosis and Therapy

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; FLUOROURACIL; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P130; PROTEIN P16; PROTEIN P53; TUMOR MARKER; WNT PROTEIN;

EID: 47949116532     PISSN: 10525157     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.giec.2008.03.003     Document Type: Review
Times cited : (15)

References (42)
  • 1
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61 5 (1990) 759-767
    • (1990) Cell , vol.61 , Issue.5 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 2
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa J.P. CpG island methylator phenotype in cancer. Nat Rev Cancer 4 12 (2004) 988-993
    • (2004) Nat Rev Cancer , vol.4 , Issue.12 , pp. 988-993
    • Issa, J.P.1
  • 3
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler K.W., and Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87 2 (1996) 159-170
    • (1996) Cell , vol.87 , Issue.2 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 4
    • 0024514647 scopus 로고
    • Allelotype of colorectal carcinomas
    • Vogelstein B., Fearon E.R., Kern S.E., et al. Allelotype of colorectal carcinomas. Science 244 4901 (1989) 207-211
    • (1989) Science , vol.244 , Issue.4901 , pp. 207-211
    • Vogelstein, B.1    Fearon, E.R.2    Kern, S.E.3
  • 5
    • 0024959672 scopus 로고
    • Clinical and pathological associations with allelic loss in colorectal carcinoma
    • [corrected]
    • Kern S.E., Fearon E.R., Tersmette K.W., et al. Clinical and pathological associations with allelic loss in colorectal carcinoma. [corrected]. JAMA 261 21 (1989) 3099-3103
    • (1989) JAMA , vol.261 , Issue.21 , pp. 3099-3103
    • Kern, S.E.1    Fearon, E.R.2    Tersmette, K.W.3
  • 6
    • 0027285475 scopus 로고
    • Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
    • Ionov Y., Peinado M.A., Malkhosyan S., et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363 6429 (1993) 558-561
    • (1993) Nature , vol.363 , Issue.6429 , pp. 558-561
    • Ionov, Y.1    Peinado, M.A.2    Malkhosyan, S.3
  • 7
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen L.A., Peltomaki P., Leach F.S., et al. Clues to the pathogenesis of familial colorectal cancer. Science 260 5109 (1993) 812-816
    • (1993) Science , vol.260 , Issue.5109 , pp. 812-816
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 8
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • Lengauer C., Kinzler K.W., and Vogelstein B. Genetic instabilities in human cancers. Nature 396 6712 (1998) 643-649
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 9
    • 0032534069 scopus 로고    scopus 로고
    • A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer
    • Boland C.R., Thibodeau S.N., Hamilton S.R., et al. A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 58 22 (1998) 5248-5257
    • (1998) Cancer Res , vol.58 , Issue.22 , pp. 5248-5257
    • Boland, C.R.1    Thibodeau, S.N.2    Hamilton, S.R.3
  • 10
    • 0036569940 scopus 로고    scopus 로고
    • Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability
    • Duval A., and Hamelin R. Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res 62 9 (2002) 2447-2454
    • (2002) Cancer Res , vol.62 , Issue.9 , pp. 2447-2454
    • Duval, A.1    Hamelin, R.2
  • 11
    • 33645396945 scopus 로고    scopus 로고
    • Genetic clonal diversity predicts progression to esophageal adenocarcinoma
    • Maley C.C., Galipeau P.C., Finley J.C., et al. Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat Genet 38 4 (2006) 468-473
    • (2006) Nat Genet , vol.38 , Issue.4 , pp. 468-473
    • Maley, C.C.1    Galipeau, P.C.2    Finley, J.C.3
  • 12
    • 0033887693 scopus 로고    scopus 로고
    • Progression model for pancreatic cancer
    • Hruban R.H., Goggins M., Parsons J., et al. Progression model for pancreatic cancer. Clin Cancer Res 6 8 (2000) 2969-2972
    • (2000) Clin Cancer Res , vol.6 , Issue.8 , pp. 2969-2972
    • Hruban, R.H.1    Goggins, M.2    Parsons, J.3
  • 13
    • 33645875880 scopus 로고    scopus 로고
    • A review of the genomics of gastric cancer
    • Hamilton J.P., and Meltzer S.J. A review of the genomics of gastric cancer. Clin Gastroenterol Hepatol 4 4 (2006) 416-425
    • (2006) Clin Gastroenterol Hepatol , vol.4 , Issue.4 , pp. 416-425
    • Hamilton, J.P.1    Meltzer, S.J.2
  • 14
    • 0032568370 scopus 로고    scopus 로고
    • E-cadherin germline mutations in familial gastric cancer
    • Guilford P., Hopkins J., Harraway J., et al. E-cadherin germline mutations in familial gastric cancer. Nature 392 6674 (1998) 402-405
    • (1998) Nature , vol.392 , Issue.6674 , pp. 402-405
    • Guilford, P.1    Hopkins, J.2    Harraway, J.3
  • 15
    • 0033594909 scopus 로고    scopus 로고
    • JC virus DNA is present in the mucosa of the human colon and in colorectal cancers
    • Laghi L., Randolph A.E., Chauhan D.P., et al. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U S A 96 13 (1999) 7484-7489
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.13 , pp. 7484-7489
    • Laghi, L.1    Randolph, A.E.2    Chauhan, D.P.3
  • 16
    • 12744280719 scopus 로고    scopus 로고
    • Detection of JC virus DNA sequences and expression of viral T antigen and agnoprotein in esophageal carcinoma
    • Del V.L., White M.K., Enam S., et al. Detection of JC virus DNA sequences and expression of viral T antigen and agnoprotein in esophageal carcinoma. Cancer 103 3 (2005) 516-527
    • (2005) Cancer , vol.103 , Issue.3 , pp. 516-527
    • Del, V.L.1    White, M.K.2    Enam, S.3
  • 17
    • 33746286876 scopus 로고    scopus 로고
    • Oncogenic T-antigen of JC virus is present frequently in human gastric cancers
    • Shin S.K., Li M.S., Fuerst F., et al. Oncogenic T-antigen of JC virus is present frequently in human gastric cancers. Cancer 107 3 (2006) 481-488
    • (2006) Cancer , vol.107 , Issue.3 , pp. 481-488
    • Shin, S.K.1    Li, M.S.2    Fuerst, F.3
  • 18
    • 10744227638 scopus 로고    scopus 로고
    • Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus
    • Ricciardiello L., Baglioni M., Giovannini C., et al. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res 63 21 (2003) 7256-7262
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7256-7262
    • Ricciardiello, L.1    Baglioni, M.2    Giovannini, C.3
  • 19
    • 33744516138 scopus 로고    scopus 로고
    • Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers
    • Goel A., Li M.S., Nagasaka T., et al. Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology 130 7 (2006) 1950-1961
    • (2006) Gastroenterology , vol.130 , Issue.7 , pp. 1950-1961
    • Goel, A.1    Li, M.S.2    Nagasaka, T.3
  • 20
    • 84865402298 scopus 로고    scopus 로고
    • JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract
    • Ricciardiello L., Laghi L., Ramamirtham P., et al. JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract. Gastroenterology 119 5 (2000) 1228-1235
    • (2000) Gastroenterology , vol.119 , Issue.5 , pp. 1228-1235
    • Ricciardiello, L.1    Laghi, L.2    Ramamirtham, P.3
  • 21
    • 0037379737 scopus 로고    scopus 로고
    • Characterization of sporadic colon cancer by patterns of genomic instability
    • Goel A., Arnold C.N., Niedzwiecki D., et al. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res 63 7 (2003) 1608-1614
    • (2003) Cancer Res , vol.63 , Issue.7 , pp. 1608-1614
    • Goel, A.1    Arnold, C.N.2    Niedzwiecki, D.3
  • 22
    • 34447251079 scopus 로고    scopus 로고
    • Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study
    • Jenkins M.A., Hayashi S., O'Shea A.M., et al. Pathology features in Bethesda guidelines predict colorectal cancer microsatellite instability: a population-based study. Gastroenterology 133 1 (2007) 48-56
    • (2007) Gastroenterology , vol.133 , Issue.1 , pp. 48-56
    • Jenkins, M.A.1    Hayashi, S.2    O'Shea, A.M.3
  • 23
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane M.F., Loda M., Gaida G.M., et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57 5 (1997) 808-811
    • (1997) Cancer Res , vol.57 , Issue.5 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3
  • 24
    • 33646196845 scopus 로고    scopus 로고
    • Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications
    • Lynch H.T., Boland C.R., Gong G., et al. Phenotypic and genotypic heterogeneity in the Lynch syndrome: diagnostic, surveillance and management implications. Eur J Hum Genet 14 4 (2006) 390-402
    • (2006) Eur J Hum Genet , vol.14 , Issue.4 , pp. 390-402
    • Lynch, H.T.1    Boland, C.R.2    Gong, G.3
  • 25
    • 0035866792 scopus 로고    scopus 로고
    • Genetic pathways in the evolution of morphologically distinct colorectal neoplasms
    • Yashiro M., Carethers J.M., Laghi L., et al. Genetic pathways in the evolution of morphologically distinct colorectal neoplasms. Cancer Res 61 6 (2001) 2676-2683
    • (2001) Cancer Res , vol.61 , Issue.6 , pp. 2676-2683
    • Yashiro, M.1    Carethers, J.M.2    Laghi, L.3
  • 26
    • 0029075933 scopus 로고
    • Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression
    • Boland C.R., Sato J., Appelman H.D., et al. Microallelotyping defines the sequence and tempo of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nat Med 1 9 (1995) 902-909
    • (1995) Nat Med , vol.1 , Issue.9 , pp. 902-909
    • Boland, C.R.1    Sato, J.2    Appelman, H.D.3
  • 27
    • 0032527902 scopus 로고    scopus 로고
    • Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas
    • Grady W.M., Rajput A., Myeroff L., et al. Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas. Cancer Res 58 14 (1998) 3101-3104
    • (1998) Cancer Res , vol.58 , Issue.14 , pp. 3101-3104
    • Grady, W.M.1    Rajput, A.2    Myeroff, L.3
  • 28
    • 20244383984 scopus 로고    scopus 로고
    • BRAF mutations in aberrant crypt foci and hyperplastic polyposis
    • Beach R., Chan A.O., Wu T.T., et al. BRAF mutations in aberrant crypt foci and hyperplastic polyposis. Am J Pathol 166 4 (2005) 1069-1075
    • (2005) Am J Pathol , vol.166 , Issue.4 , pp. 1069-1075
    • Beach, R.1    Chan, A.O.2    Wu, T.T.3
  • 29
    • 0842329668 scopus 로고    scopus 로고
    • Hyperplastic polyps and colorectal cancer: is there a link?
    • Jass J.R. Hyperplastic polyps and colorectal cancer: is there a link?. Clin Gastroenterol Hepatol 2 1 (2004) 1-8
    • (2004) Clin Gastroenterol Hepatol , vol.2 , Issue.1 , pp. 1-8
    • Jass, J.R.1
  • 30
    • 33750682008 scopus 로고    scopus 로고
    • High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy
    • Spring K.J., Zhao Z.Z., Karamatic R., et al. High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology 131 5 (2006) 1400-1407
    • (2006) Gastroenterology , vol.131 , Issue.5 , pp. 1400-1407
    • Spring, K.J.1    Zhao, Z.Z.2    Karamatic, R.3
  • 31
    • 0037468517 scopus 로고    scopus 로고
    • Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH
    • Sieber O.M., Lipton L., Crabtree M., et al. Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N Engl J Med 348 9 (2003) 791-799
    • (2003) N Engl J Med , vol.348 , Issue.9 , pp. 791-799
    • Sieber, O.M.1    Lipton, L.2    Crabtree, M.3
  • 32
    • 20244386256 scopus 로고    scopus 로고
    • Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X
    • Lindor N.M., Rabe K., Petersen G.M., et al. Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. JAMA 293 16 (2005) 1979-1985
    • (2005) JAMA , vol.293 , Issue.16 , pp. 1979-1985
    • Lindor, N.M.1    Rabe, K.2    Petersen, G.M.3
  • 34
    • 27744511296 scopus 로고    scopus 로고
    • Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis
    • Sweet K., Willis J., Zhou X.P., et al. Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis. JAMA 294 19 (2005) 2465-2473
    • (2005) JAMA , vol.294 , Issue.19 , pp. 2465-2473
    • Sweet, K.1    Willis, J.2    Zhou, X.P.3
  • 35
    • 0035927967 scopus 로고    scopus 로고
    • Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations
    • Huntsman D.G., Carneiro F., Lewis F.R., et al. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. N Engl J Med 344 25 (2001) 1904-1909
    • (2001) N Engl J Med , vol.344 , Issue.25 , pp. 1904-1909
    • Huntsman, D.G.1    Carneiro, F.2    Lewis, F.R.3
  • 36
    • 3142670867 scopus 로고    scopus 로고
    • Familial pancreatic cancer
    • Rieder H., and Bartsch D.K. Familial pancreatic cancer. Fam Cancer 3 1 (2004) 69-74
    • (2004) Fam Cancer , vol.3 , Issue.1 , pp. 69-74
    • Rieder, H.1    Bartsch, D.K.2
  • 37
    • 30044447282 scopus 로고    scopus 로고
    • Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome
    • Wong P., Verselis S.J., Garber J.E., et al. Prevalence of early onset colorectal cancer in 397 patients with classic Li-Fraumeni syndrome. Gastroenterology 130 1 (2006) 73-79
    • (2006) Gastroenterology , vol.130 , Issue.1 , pp. 73-79
    • Wong, P.1    Verselis, S.J.2    Garber, J.E.3
  • 38
    • 0028321495 scopus 로고
    • Allelic loss of chromosome 18q and prognosis in colorectal cancer
    • Jen J., Kim H., Piantadosi S., et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 331 4 (1994) 213-221
    • (1994) N Engl J Med , vol.331 , Issue.4 , pp. 213-221
    • Jen, J.1    Kim, H.2    Piantadosi, S.3
  • 39
    • 0034642605 scopus 로고    scopus 로고
    • Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer
    • Gryfe R., Kim H., Hsieh E.T., et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 342 2 (2000) 69-77
    • (2000) N Engl J Med , vol.342 , Issue.2 , pp. 69-77
    • Gryfe, R.1    Kim, H.2    Hsieh, E.T.3
  • 40
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic C.M., Sargent D.J., Moore M.J., et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 349 3 (2003) 247-257
    • (2003) N Engl J Med , vol.349 , Issue.3 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 41
    • 10744228074 scopus 로고    scopus 로고
    • Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer
    • Carethers J.M., Smith E.J., Behling C.A., et al. Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer. Gastroenterology 126 2 (2004) 394-401
    • (2004) Gastroenterology , vol.126 , Issue.2 , pp. 394-401
    • Carethers, J.M.1    Smith, E.J.2    Behling, C.A.3
  • 42
    • 10844281210 scopus 로고    scopus 로고
    • Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population
    • Imperiale T.F., Ransohoff D.F., Itzkowitz S.H., et al. Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N Engl J Med 351 26 (2004) 2704-2714
    • (2004) N Engl J Med , vol.351 , Issue.26 , pp. 2704-2714
    • Imperiale, T.F.1    Ransohoff, D.F.2    Itzkowitz, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.