Cervical biopsy and excision procedure specimens lack sufficient predictive value for lymph-vascular space invasion seen at hysterectomy for cervical cancer

American Journal of Obstetrics and Gynecology

Volumn 199, Issue 2, 2008, Pages 151.e1-151.e4

  Bidus, Michael A ^a   Caffrey, Angela S ^b   You, Whitney B ^a   Amezcua, Charles A ^c   Chernofsky, Mildred R ^a   Barner, Ross ^a   Seidman, Jeffrey ^d   Rose, G Scott ^a  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d WASHINGTON HOSPITAL CENTER   (United States)

Author keywords

cervix cancer; lymph vascular space invasion (LVSI)

Indexed keywords

ADULT; ARTICLE; CANCER INVASION; CHI SQUARE TEST; CONFIDENCE INTERVAL; DATA ANALYSIS; EXCISION; FEMALE; HUMAN; HUMAN TISSUE; HYSTERECTOMY; LYMPH NODE; MAJOR CLINICAL STUDY; PREDICTIVE VALIDITY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; STATISTICAL SIGNIFICANCE; UTERINE CERVIX BIOPSY; UTERINE CERVIX CANCER;

EID: 47949115756     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2008.02.017     Document Type: Article

References (16)

1. Landoni F., Maneo A., Colombo A., et al. Randomized study of radical surgery versus radiotherapy for stage IB-IIA cervical cancer. Lancet 350 (1997) 535-540
2. Sedlis A., Bundy B.N., Rotman M.Z., Lentz S.S., Muderspach L.I., and Zaino R.J. A randomized trial of pelvic radiation therapy versus no further therapy in selected patients with stage IB carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy: a Gynecologic Oncology Group study. Gynecol Oncol 73 (1999) 177-183
3. Peters III W.A., Liu P.Y., Barrett II R.J., et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18 (2000) 1606-1613
4. Rose P.G., Bundy B.N., Watkins E.B., et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer. N Eng J Med 340 (1999) 1144-1153
5. Takeda N., Sakuragi N., Takeda M., et al. Multivariate analysis of histopathologic prognostic factors for invasive cervical cancer treated with radical hysterectomy and systemic retroperitoneal lymphadenectomy. Acta Obstet Gynecol Scand 81 (2002) 144-151
6. Ayhan A., Al R.A., Baykai C., Demirtas E., Ayhan A., and Yuce K. Prognostic factors in FIGO stage IB cervical cancer without lymph node metastasis and the role of adjuvant radiotherapy after radical hysterectomy. Int J Gynecol Cancer 14 (2004) 286-292
7. Ho C.M., Chien T.Y., Huang S.H., Wu C.J., Shih B.Y., and Chang S.C. Multivariate analysis of the prognostic factors and outcomes in early cervical cancer patients undergoing radical hysterectomy. Gynecol Oncol 93 (2004) 458-464
8. Sevin B.U., Lu Y., Bioch D.A., Nadji M., Koetchli O.R., and Averette H.E. Surgically defined prognostic parameters in patients with early cervical carcinoma: a multivariate survival tree analysis. Cancer 78 (1996) 1438-1446
9. Kamelle S.A., Rutledge T.L., Tillmanns T.D., et al. Surgical-pathological predictors of disease-free survival and risk groupings for IB2 cervical cancer: do the traditional models still apply?. Gynecol Oncol 94 (2004) 249-255
10. Raspagliesi F., Ditto A., Quattrone P., et al. Prognostic factors in microinvasive cervical squamous cell cancer: long-term results. Int J Gynecol Cancer 15 (2005) 88-93
11. Marchiole P., Buenerd A., Benchaib M., Nezhat K., Dargent D., and Mathevet P. Clinical significance of lymphovascular space involvement and lymph node micrometastases in early-stage cervical cancer: a retrospective case-control surgico-pathological study. Gynecol Oncol 97 (2005) 727-732
12. Chernofsky M.R., Felix J.C., Muderspach L.I., et al. Influence of quantity of lymph vascular space invasion on time to recurrence in women with early-stage squamous cancer of the cervix. Gynecol Oncol 100 (2006) 288-293
13. Rutledge T.L., Kamelle S.A., Tillmanns T.D., et al. A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy: is size the real difference?. Gynecol Oncol 95 (2004) 70-76
14. Alexander-Sefre F., Singh N., Ayhan A., Thomas J.M., and Jacobs I.J. Clinical value of immunohistochemically detected lymphovascular invasion in endometrioid endometrial cancer. Gynecol Oncol 92 (2004) 653-659
15. Tsuruchi N., Kaku T., Kamura T., et al. The prognostic significance of lymphovascular space invasion in endometrial cancer when conventional hematoxylin and eosin staining is compared to immunohistochemical staining. Gynecol Oncol 57 (1995) 307-312
16. Alexander-Sefre F., Singh N., Ayhan A., Salverson H.B., Wilbanks G., and Jacobs I.J. Detection of tumour lymphovascular space invasion using dual cytokeratin and CD31 immunohistochemistry. J Clin Pathol 56 (2003) 786-788