Drug release behavior from in situ gelatinized thermosensitive nanogel aqueous dispersions

International Journal of Pharmaceutics

Volumn 361, Issue 1-2, 2008, Pages 189-193

  Wang, Qin ^a   Xu, Huibi ^a   Yang, Xiangliang ^a   Yang, Yajiang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Drug release; In situ gelatinized nanogel dispersion; Thermosensitive

Indexed keywords

BOVINE SERUM ALBUMIN; COPOLYMER; CROSS LINKING REAGENT; FLUOROURACIL; NANOPARTICLE; POLY(N ISOPROPYLACRYLAMIDE CO ACRYLAMIDE);

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; DRUG RELEASE; GELATINIZATION; HEAT SENSITIVITY; MACROMOLECULE; MALE; MOLECULAR WEIGHT; NONHUMAN; PHASE TRANSITION; POLYMERIZATION; PRECIPITATION; PRIORITY JOURNAL; RAT; TISSUE ENGINEERING;

ACRYLIC RESINS; ANIMALS; CATTLE; CROSS-LINKING REAGENTS; DRUG CARRIERS; FLUOROURACIL; GELS; MOLECULAR WEIGHT; NANOPARTICLES; PHASE TRANSITION; SERUM ALBUMIN, BOVINE; TEMPERATURE;

EID: 47949115467     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.05.011     Document Type: Article

References (19)

1. Bradford M. A rapid and sensitive method for the quantitation of mircogram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
2. Crowther H.M., and Vincent B. Swelling behavior of poly-N-isopropylacrylamide microgel particles in alcoholic solutions. Colloid Polym. Sci. 276 (1998) 46-51
3. Huang G., Gao J., Hu Z.B., John J.V.St., Ponder B.C., and Moro D. Controlled drug release from hydrogel nanoparticle networks. J. Controlled Release 94 (2004) 303-311
4. Huo D.X., Li Y.N., Qian Q.W., and Kobayashi T. Temperature-pH sensitivity of bovine serum albumin protein-microgels based on cross-linked poly(N-isopropylacrylamide-co-acrylic acid). Colloids Surf. B: Biointerfaces 50 (2006) 36-42
5. Hu Z.B., and Xia X.H. Hydrogel nanoparticle dispersions with inverse thermoreversible gelation. Adv. Mater. 16 (2004) 305-309
6. Jeong B., Bae Y.H., and Kim S.W. Thermoreversible gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions. Macromolecules 32 (1999) 7064-7069
7. Kawaguchi H., Fujimoyo K., and Mizuhara Y. Temperature-dependent adsorption of proteins on poly(N-isopropylacrylamide) hydrogel microspheres. J. Colloid Polym. Sci. 270 (1992) 53-57
8. Li S.K., and D'Emanuele A. On-off transport through a thermoresponsive hydrogel composite membrane. J. Controlled Release 75 (2001) 55-67
9. Matsumura Y., and Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor vehicles smancs. Cancer Res. 46 (1986) 6387-6392
10. Ogawa K., Nakayama A., and Kokufuta E. Preparation and characterization of thermosensitive polyampholyte nanogels. Langmuir 19 (2003) 3178-3184
11. Pelton R.H., and Chibante P. Preparation of aqueous lattices with N-isopropylacrylamide. Colloids Surf. 20 (1986) 247-256
12. Pelton R.H. Temperature-sensitive aqueous microgels. Adv. Colloid Interface Sci. 85 (2000) 1-33
13. Senff H., and Richtering W. Influence of crosslink density on rheological properties of temperature sensitive microgel suspensions. Colloid Polym. Sci. 278 (2000) 830-840
14. Siepmann J., Faisant N., Akiki J., Richard J., and Benoit J.P. Effect of the size of biodegradable microparticles on drug release: experiment and theory. J. Controlled Release 96 (2004) 123-134
15. Tanaka T. Collapse of gels and the critical endpoint. Phys. Rev. Lett. 40 (1978) 820-823
16. Wang Q., Zhao Y.B., Yang Y.J., Xu H.B., and Yang X.L. Thermosensitive phase behavior and drug release of in situ gelable poly(N-isopropylacrylamide-co-acrylamide) microgels. Colloid Polym. Sci. 285 (2007) 515-521
17. Zhang X.Z., Zhuo R.X., Cui J.Z., and Zhang J.T. A novel thermo-responsive drug delivery system with positive controlled release. Int. J. Pharm. 235 (2002) 43-50
18. Zhang Y., Zhu W., Wang B.B., and Ding J.D. A novel microgel and associated post-fabrication encapsulation technique of proteins. J. Controlled Release 105 (2005) 260-268
19. Zhao Y., Zhang G.Z., and Wu C. Nonergodic dynamics of a novel thermally sensitive hybrid gel. Macromolecules 34 (2001) 7804-7808