A novel thermo-responsive drug delivery system with positive controlled release

International Journal of Pharmaceutics

Volumn 235, Issue 1-2, 2002, Pages 43-50

  Zhang, Xian Zheng ^a,b   Zhuo, Ren Xi ^a   Cui, Jing Zhou ^a   Zhang, Jiao Tao ^a  

^a WUHAN UNIVERSITY   (China)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Controlled release; Drug delivery system; Hydrogel; Poly(N isopropylacrylamide); Thermo responsive

Indexed keywords

FLUOROURACIL; POLY(N ISOPROPYLACRYLAMIDE);

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED DRUG RELEASE; DIALYSIS MEMBRANE; DRUG DELIVERY SYSTEM; HYDROGEL; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; COLD; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; FLUOROURACIL; HEAT; HYDROGELS;

EID: 0037139355     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00976-0     Document Type: Article

References (36)

1. Thermosensitive polymers as on-off switches for drug release
2. Insulin permeation through sensitive hydrogels
3. Temperature dependence of swelling of crosslinked poly(N,N-alkyl substituted acrylamides) in water
4. Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery
5. Gels as size selective extraction solvents
6. Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers
7. Volume phase transition in a nonionic gel
8. Application of thermally reversible polymers and hydrogels in therapeutics and diagnostics
9. Environmentally sensitive polymers and hydrogels 'Smart' biomaterials
10. Thermally reversible hydrogels. II. Delivery and selective removal of substances from aqueous solutions
11. Phase transition of N-substituted acrylamide gels
12. Synthesis of fast-response, temperature-sensitive poly(N-isopropylacrylamide) gel
13. Influence of freely mobile grafted chain length on dynamic properties of comb-type grafted poly(N-isopropylacrylamide) hydrogels
14. Rapid deswelling response of poly(N-isopropylacrylamide) hydrogels by the formation of water release channels using poly(ethylene oxide) graft chains
15. Hydrogels: Swelling, drug loading, and release
16. Core-shell type polymeric nanoparticles composed of poly(L-lactic acid) and poly(N-isopropylacrylamide)
17. Responsive polymeric delivery systems
18. Reversible surface properties of glass plate and capillary tube grafted by photopolymerization of N-isopropylacrylamide
19. Synthesis of thermal phase separating reactive polymers and their applications in immobilized enzymes
20. Kinetics of discontinuous volume-phase transition of gels
21. Thermo-responsive polymeric hydrogels and their application to pulsatile drug release
22. Temperature modulated protein release from pH/temperature-sensitive hydrogels
23. pH-sensitive hydrogels for site-specific drug delivery: II. Drug release behaviour from crosslinked alkyl acrylates/methacrylic acid copolymers
24. Poly(N-isopropylacrylamide): Experiment, theory and application
25. Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery
26. Dynamic contact angle measurement of temperature-responsive surface properties for poly(N-isopropylacrylamide) grafted surfaces
27. NMR study of poly(N-isopropylacrylamide) gels near phase transition
28. Light-scattering study of coil-to-globule transition of a poly(N-isopropylacrylamide) chain in deuterated water
29. Comparison of the coil-to-globule and the globule-to-coil transitions of a single poly (N-isopropylacrylamide) homopolymer chain in water
30. Synthesis and characterization of thermally reversible macroporous poly(N-isopropylacrylamide) hydrogels
31. Comb-type grafted hydrogels with rapid de-swelling response to temperature changes
32. Preparation of fast responsive, temperature-sensitive poly(N-isopropylacrylamide) hydrogel
33. Synthesis and characterization of a novel thermosensitive gel with fast response
34. A novel method to prepare a fast responsive, thermosensitive poly(N-isopropylacrylamide) hydrogel
35. Preparation of fast responsive, thermally sensitive poly(N-isopropylacrylamide)gel
36. Dynamic properties of temperature-sensitive poly(N-isopropylacrylamide) gel cross-linked through siloxane linkage