Mortality of the elderly is still exceedingly high at diagnosis of AIDS despite favourable outcomes after highly active antiretroviral therapy in Recife, Brazil

International Journal of STD and AIDS

Volumn 19, Issue 7, 2008, Pages 450-454

  Lacerda, Heloisa Ramos ^a,c   Kitner, D ^a,b  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b Hospital Correia Picanço Secretaria de Saúde   (Brazil)

^c NONE   (Brazil)

Author keywords

Acquired immunodeficiency syndrome; Elderly; Highly active antiretroviral therapy

Indexed keywords

PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; BRAZIL; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DELAYED DIAGNOSIS; ELDERLY CARE; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; AGE FACTORS; AGED; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BRAZIL; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; HIV INFECTIONS; HUMANS; MIDDLE AGED; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY;

EID: 47949109551     PISSN: 09564624     EISSN: None     Source Type: Journal    
DOI: 10.1258/ijsa.2008.007317     Document Type: Article

References (29)

1. Brazilian Ministry of Health. National program of STD and AIDs. Epidemiol Bull AIDS STD 2007;1
2. Centers for Disease Control and Prevention. AIDS among persons aged ≥50 years: United States, 1991-1996. Morb Mort Wkly Rep 1998;47:21-7
3. Peate I. Human immunodeficiency virus and the older person. Br J Nurs 2007;16:606-10
4. Palella FJ Jr, Delaney MS, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998;338:853-60
5. Auerbach JD. HIV/AIDS and aging: interventions for older adults. J Acquir Immun Defic Syndr 2003;33:S57-8
6. Gordon SM, Thompson S. The changing epidemiology of human immunodeficiency virus infection in older persons. J Am Geriatr Soc 1995;43:7-9
7. Joint United Nations Programme on HIV/AIDS. Impact of AIDS on Older Populations. Report on the Global HIV/AIDS Epidemic. Geneva: UNAIDS Secretariat 2002
8. Grandon JD. HIV infection in the older population. Clin Geriatr 2004;12:37-45
9. Manfredi R. HIV disease and advanced age - an increasing therapeutic challenge. Drugs Aging 2002;19:647-69
10. Knobel H, Guelar A, Valldecillo G, Carmona A, Gonzaléz A, López-Colomés JL. Response to highly active antiretroviral therapy in HIV-infected patients aged 60 years or older after 24 months follow-up. AIDS 2001;15:1591-3
11. Tumbarello M, Rabagliati R, Donati KG, et al. Older HIV-positive patients in the era of highly active antiretroviral therapy: changing of a scenario. AIDS 2003;17:128-31
12. El-Sadr W, Welter J. Unrecognized human immunodeficiency virus infection in the elderly. Arch Int Med 1995;155:184-6
13. Chiao EY, Ries KM, Sande MA. AIDS and the elderly. Clin Infect Dis 1999;28:740-5
14. Manfredi R, Chiodo F. A case-control study of virological anda immunological effects of highly active antiretroviral therapy in HIV-infected patients with advanced age. AIDS 2000;14:1475-7
15. Goetz MB, Boscardin WJ, Dorothy W, Alasspooles S. Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy. AIDS 2001;15:1576-9
16. Brazilian Institute of Geography and Statistics [http://www.ibge.gov.br/ ibgeteen/datas/idoso/política_do_idoso_no_brasil.html]. (accessed on 8 November 2007)
17. Zelenetz PD, Epstein ME. HIV in the elderly. AIDS Patient Care 1998;12:255-62
18. Perez JL, Moore RD. Greater effect of highly active antiretroviral therapy on survival in people aged ≥ 50 years compared with younger people in an urban observational cohort. Clin Infect Dis 2003;36:212-8
19. Inungu JN, Mokotoff ED, Kent JB. Characteristics of HIV Infection in patients fifty years or older in Michigan. AIDS Patient Care STDs 2001;15:567-73
20. Skiest DJ, Rubinstien E, Carley N, Gioiella L, Lyons R. The importance of comorbidity in HIV-infected patients over 55: a retrospective case-control study. Am J Med 1996;101:605-11
21. Grimes RM, Otiniano ME, Rodriguez-Barradas MC, Lai D. Clinical experience with human immunodefficiency vírus-infected older patients in the era of effective antiretroviral therapy. Clin Infect Dis 2002;34:1530-3
22. Melo LSW, Ramos H, Ximenes RAA, Campelo EH, Moraes EF. Sobrevida dos pacientes com Aids e características dos que evoluíram para óbito, em oito anos de terapia anti-retroviral potente numa unidade de referência do Nordeste, Brasil. Brazil J Infect Dis 2007;11:S20
23. Nogueras M, Navarro G, Antón E, et al. Epidemiological and clinical features, response to HAART, and survival in HIV-infected patients diagnosed at the age of 50 or more. BMC Infect Dis 2006;6:159
24. Tumbarello M, Rabagliati R, Donati KG, et al. Older age does not influence CD4 cell recovery in HIV-1 infected patients receiving highly active anti retroviral therapy. BMC Infect Dis 2004;4:46-56
25. Raviglione MC, Snider DE, Kochi A. Global epidemiology of tuberculosis morbidity and mortality of a worldwide epidemic. JAMA 1995;273:220-6
26. Viard J, Mocroft A, Chiesi A, et al. EuroSIDA Study Group. Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J Infect Dis 2001;183:1290-4
27. Chidgey A, Dudakov J, Seach N, Boyd R. Impact of niche aging on thimic regeneration and immune reconstitution. Semin Immunol 2007;19:331-40
28. Saltzman RI, Peterson PK. Immunodeficiency of the elderly. Rev Infect Dis 1987;9:1127-9
29. Grabar S, Kousignian I, Sobel A, et al. Immunological and clinical responses to highly active antiretroviral therapy over 50 years of age. Results from the French Hospital Database on HIV. AIDS 2004;18:2029-38