Older age does not influence CD4 cell recovery in HIV-1 infected patients receiving Highly Active Anti Retroviral Therapy

BMC Infectious Diseases

Volumn 4, Issue , 2004, Pages

  Tumbarello, Mario ^a   Rabagliati, Ricardo ^b   de Gaetano Donati, Katleen ^a   Bertagnolio, Silvia ^a   Montuori, Eva ^a   Tamburrini, Enrica ^a   Tacconelli, Evelina ^a   Cauda, Roberto ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ANTACID AGENT; ANTIVIRUS AGENT; CD4 ANTIGEN; CORTICOSTEROID; PROTEINASE INHIBITOR; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TUBERCULOSTATIC AGENT;

ADULT; ANEMIA; ARTICLE; CASE CONTROL STUDY; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG RESPONSE; DYSLIPIDEMIA; EPIDEMIOLOGICAL DATA; GASTROINTESTINAL SYMPTOM; HELPER CELL; HEPATITIS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERGLYCEMIA; IMMUNE RESPONSE; IMMUNE SYSTEM; KIDNEY COLIC; LIPODYSTROPHY; LOW DRUG DOSE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; OUTCOMES RESEARCH; PANCREATITIS; PERIPHERAL NEUROPATHY; PROSPECTIVE STUDY; RASH; STATISTICAL SIGNIFICANCE; THROMBOCYTOPENIA; AGE; CARDIOVASCULAR DISEASE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; DRUG EFFECT; FEMALE; GASTROINTESTINAL DISEASE; IMMUNOLOGY; ITALY; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL;

ADULT; AGE FACTORS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COMORBIDITY; DIABETES MELLITUS, TYPE 2; FEMALE; GASTROINTESTINAL DISEASES; HIV INFECTIONS; HUMANS; ITALY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 10144255904     PISSN: 14712334     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2334-4-46     Document Type: Article

References (45)

1. Centers for Disease Control and Prevention: HIV and AIDS-United States, 1981-2000. Morb Mortal Wkly Rep 2001; 50 430-434.
2. Ferro S, Salit IE: HIV infection in patients over 55 years of age. J Acquir Immune Defic Syndr 1992;5:348-355.
3. Ena J, Valls V, Lopez Aldeguer J, Garcia Gasco MP, Anon S, Navarro V, Sanchez R, Boix V, Portilla J, Roig P, Masia MM, Maestre Peiro A: Clinical presentation of HIV infection in patients aged 50 years or older. J Infect 1998;37:213-216.
4. Phillips AN, Lee CA, Elford J, Webster A, Janossy G, Timms A, Bofill M, Kernoff PB: More rapid progression to AIDS in older HIV-infected people: the role of CD4+ T-cell counts. J Acquir Immune Defic Syndr 1991;4:970-975.
5. Operskalski EA, Stram DO, Lee H, Zhou Y, Donegan E, Busch MP, Stevens CE, Schiff ER, Dietrich SL, Mosley JW: Human immunodeficiency virus type 1 infection: relationship of risk group and age to rate of progression to AIDS. J Infect Dis 1995;172:648-655.
6. O'Brien TR, Blattner WA, Waters D, Eyster E, Hilgartner MW, Cohen AR, Luban N, Hatzakis A, Aledort LM, Rosenberg PS, Miley WJ, Kroner BL, Goedert JJ: Serum HIV-1 RNA levels and time to development of AIDS in the Multicenter Hemophilia Cohort Study. JAMA 1996; 276 105-110.
7. Soriano V, Castilla J, Gomez-Cano M, Holguin A, Villalba N, Mas A, Gonzalez-Lahoz J: The decline in CD4+ T lymphocytes as a function of the duration of HIV infection, age at seroconversion, and viral load. J Infect 1998;36:307-311.
8. Ship JA, Wolff A, Selik RM: Epidemiology of acquired immune deficiency syndrome in persons aged 50 years or older. J Acquir Immune Defic Syndr 1991;4:84-88.
9. Carre N, Deveau C, Belanger F, Boufassa F, Persoz A, Jadand C, Rouzioux C, Delfraissy JF, Bucquet D: Effect of age exposure group on the onset of AIDS in heterosexual and homosexual HIV-infected patients.AIDS 1994;8:797-802.
10. Skiest DJ, Rubinstien E, Carley N, Gioiella L, Lyons R: The importance of comorbidity in HIV-infected patients over 55: a retrospective case-control study. Am J Med 1996;101: 605-611.
11. Darby SC, Ewart DW, Giangrande PLF, Spooner RJ, Rizza CR: Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. Lancet 1996; 347 1573-1579.
12. Tumbarello M, Tacconelli E, Cauda R, Ortona L: Age as a prognostic factor in AIDS. Lancet 1996;348:623-624.
13. Baslev U, D'Arminio Monforte A, Stergiou G, Antunes F, Mulcahy F, Pehrson PO, Phillips A, Pedersen C, Lundgren JD: Influence of age on rates of new AIDS defining diseases and survival in 6546 AIDS patients. Scand J Infect Dis 1997;29:337-343.
14. Butt AA, Dascomb KK, De Salvo KB, Bazzano L, Kissinger PJ, Szerlip HM: Human immunodeficiency virus infection in elderly patients. South Med J 2001;94:397-400.
15. Manfredi R, Chiodo F: A case control study of virological and immunological effects of highly active antiretroviral therapy in HIV-infected patients with advanced age. AIDS 2000;14 1475-1477.
16. Goetz MB, Boscardin WJ, Wiley D, Alkasspooles S: Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy. AIDS 2001;15 1576-1579.
17. Viard JP, Mocroft A, Chiesi A, Kirk O, Roge B, Panos G, Vetter N, Bruun JN, Johnson M, Lundgren JD; EuroSIDA Study Group: Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J Infect Dis 2001;183 1290-1294.
18. Knobel H, Guelar A, Valldecillo G, Carmona A, Gonzalez A, Lopez-Colomes JL, Saballs P, Gimeno JL, Diez A: Response to Highly Active Antiretroviral Therapy in HIV-infected patients aged 60 years or older after 24 months follow-up. AIDS 2001; 15:1591-1593.
19. Grimes RM, Otiniano ME, Rodriguez-Barradas MC, Lai D: Clinical experience with human immunodeficiency virus-infected older patients in the era of effective antiretroviral therapy. Clin Infect Dis 2002;34:1530-1533.
20. Paredes R, Mocroft A, Kirk O, Lazzarin A, Barton SE, van Lunzen J, Katzenstein TL, Antunes F, Lundgren JD, Clotet B: Predictors of virological success and ensuing failure in HIV-positive patients starting Highly Active Antiretroviral Therapy in Europe. Arch Intern Med 2000;160:1123-1132.
21. Centers for Disease Control and Prevention: 1993 Classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morb Mortal Wkly Rep 1992;41:1-19.
22. Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chron Dis 1987; 40:373-383.
23. Inungu JN, Mokotoff ED, Kent JB: Characteristics of HIV infection in patients fifty years or older in Michigan. AIDS Patient Care STDs 2001;15:567-573.
24. El-Sadr W, Gettler J: Unrecognized Human Immunodeficiency Virus infection in the elderly. Arch Intern Med 1995; 155 184-186.
25. Adler WH, Baskar PV, Chrest FJ, Dorsey-Cooper B, Winchurch RA, Nagel JE: HIV infection and aging: mechanisms to explain the accelerated rate of progression in the older patient. Mech Ageing Dev 1997;96:137-155.
26. Ginaldi L, De Martinis M, D'Ostilio A, Marini L, Loreto MF, Martorelli V, Quaglino D: The immune system in the elderly. Immunologic Res 1999;20:109-115.
27. Centers for Disease Control and Prevention: AIDS among persons aged ≥ 50 years- United States, 1991-1996. Morb Mortal Wkly Rep 1998;47:21-27.
28. Stall R, Catania J: AIDS risk behaviour among late middle-aged and elderly americans. Arch Intern Med 1994; 154 57-63.
29. Chiao EY, Ries KM, Sande MA: AIDS and the elderly. Clin Infect Dis 1999;28:740-745.
30. Vella S, Giuliano M, Floridia M, Chiesi A, Tomino C, Seeber A, Barcherini S, Bucciardini R, Mariotti S: Effect of sex, age and transmission category on the progression to AIDS and survival of zidovudine-treated symptomatic patients.AIDS 1995; 9:51-56.
31. Keller MJ, Hausdorff JM, Kyne L, Wei JY: Is age a negative prognostic indicator in HIV infection or AIDS?Aging Clin Exp Res 1999;11:35-38.
32. Tumbarello M, Rabagliati R, de Gaetano Donati K, Bertagnolio S, Tamburrini E, Tacconelli E, Cauda R: Older HIV-positive subjects in the HAART era: changing of a scenario. AIDS 2003;17 128-131.
33. Skiest DJ: The importance of co-morbidity in older HIV-infected patients. AIDS 2003;17:1577.
34. Adeyemi OM, Badri SM, Max B, Chinomona N, Barker D: HIV infection in older patients. CID 2003;36:1347.
35. Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, Wagener MM, Singh N: Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Ann Intern Med 2000;133:21-30.
36. Cingolani A, Antinori A, Rizzo MG, Murri R, Ammassari A, Baldini F, Di Giambenedetto S, Cauda R, De Luca A: Usefulness of monitoring HIV drug resistance and adherence in individuals failing highly active antiretroviral therapy: a randomized study. AIDS 2002;16:369-379.
37. Hinkin CH, Hardy DJ, Mason KI, Castellon SA, Durvasula RS, Lam MN, Stefaniak M: Medication adherence in HIV-infected adults: effect of patient age, cognitive status, and substance abuse. AIDS 2004,18 (Suppl 1):S19-S25.
38. Renaud M, Katlama C, Mallet A, Calvez V, Carcelain G, Tubiana R, Jouan M, Caumes E, Agut H, Bricaire F, Debre P, Autran B: Determinants of paradoxical CD4 cell reconstitution after protease inhibitor-containing antiretroviral regimen. AIDS 1999; 13 669-676.
39. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, Polis MA, Haase AT, Feinberg MB, Sullivan JL, Jamieson BD, Zack JA, Picker LJ, Koup RA: Changes in thymic function with age and during the treatment of HIV infection. Nature 1998;396:690-695.
40. Carcelain G, Debré P, Autran B: Reconstitution of CD4+ T lymphocytes in HIV-infected individuals following antiretroviral therapy. Curr Opin Immunol 2001;13:483-488.
41. Operskalsky EA, Mosley JW, Busch MP, Stram DO: Influences of age, viral load and CD4+ count on the rate of progression of HIV-1 infection to AIDS. J Acquired Immune Defic Syndr Hum Retrovirol 1997;15:243-244.
42. Goodkin K, Shapshak P, Asthana D, Zheng W, Concha M, Wilkie FL, Molina R, Lee D, Suarez P, Symes S, Khamis I: Older age and plasma viral load in HIV-1 infection. AIDS 2004;18 (Suppl 1):S87-S98.
43. de Gaetano Donati K, Rabagliati R, Tumbarello M, Tacconelli E, Amore C, Cauda R, Iacoviello L: Increased soluble markers of endothelial dysfunction in HIV-positive patients under Highly Active Antiretroviral Therapy. AIDS 2003;17:765-768.
44. Laurence J: Vascular complications associated with use of HIV protease inhibitors. Lancet 1998;351:1960.
45. Henry K, Melroe H, Huebsch J, Hermundson J, Levine C, Swensen L, Daley J: Severe premature coronary artery disease with protease inhibitors. Lancet 1998;351:1328.