Expression levels of the human DNA repair protein metnase influence lentiviral genomic integration

Biochimie

Volumn 90, Issue 9, 2008, Pages 1422-1426

  Williamson, Elizabeth A ^a   Farrington, Jacqueline ^a   Martinez, Leah ^a   Ness, Scott ^b   O'Rourke, John ^b   Lee, Suk Hee ^c   Nickoloff, Jac ^b   Hromas, Robert ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA repair; Genomic integration; Histone methylation; Lentivirus; Transposase

Indexed keywords

BLASTICIDIN S; DOUBLE STRANDED DNA; HISTONE; PROTEIN METNASE; TRANSPOSASE;

ARTICLE; CELL LINE; CELL STRAIN HEK293; CONTROLLED STUDY; DNA INTEGRATION; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; LENTIVIRINAE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL LINE; DNA REPAIR; GENE EXPRESSION REGULATION; GENOME, VIRAL; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; LENTIVIRUS;

LENTIVIRUS;

EID: 47949106091     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2008.05.010     Document Type: Article

References (16)

1. Lee S.-H., Oshige M., Durant S.T., Rasila K.K., Williamson E.A., Ramsey H., Kwan L., Nickoloff J.A., and Hromas R. The SET domain protein Metnase mediates foreign DNA integration and links integration to nonhomologous end-joining repair. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 18075-18080
2. Li L., Olvera J.M., Yoder K.E., Mitchell R.S., Butler S.L., Lieber M., Martin S.L., and Bushman F.D. Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection. EMBO J. 20 (2001) 3272-3281
3. Daniel R., Katz R.A., and Skalka A.M. A role for DNA-PK in retroviral DNA integration. Science 284 (1999) 644-647
4. Jeanson L., Subra F., Vaganay S., Hervy M., Marangoni E., Bourhis J., and Mouscadet J.F. Effect of Ku80 depletion on the preintegrative steps of HIV-1 replication in human cells. Virology 300 (2002) 100-108
5. Gaken J.A., Tavassoil M., Gan S.U., Vallian S., Giddings I., Darling D.C., Galea-Lauri J., Thomas M.G., Abedi H., Schreiber V., Menissier-de Murcia J., Collins M.K., Shall S., and Farzaneh F. Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity. J. Virol. 70 (1996) 3992-4000
6. Ha H.C., Juruli K., Zhou Y., Leung S., Hermankova M., and Snyder S.H. Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 3364-3368
7. Daniel R., Katz R.A., Merkel G., Little J.C., Yen T.J., and Skalka A.M. Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Mol. Cell. Biol. 21 (2001) 1164-1172
8. Daniel R., Kao G., Taganov K., Greger J.G., Favorova O., Merkel G., Yen T.J., Katz R.A., and Skalka A.M. Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 4778-4783
9. Mulder L.C., Chakrabarti L.A., and Muesing M.A. Interaction of HIV-1 integrase with DNA repair protein hRad18. J. Biol. Chem. 277 (2002) 27489-27493
10. Butler S.L., Hansen M.S., and Bushman F.D. A quantitative assay for HIV DNA integration in vivo. Nat. Med. 7 (2001) 631-634
11. Baekelandt V., Claeys A., Cherepanov P., De Clercq E., De Strooper B., Nuttin B., and Debyser Z. DNA-dependent protein kinase is not required for efficient lentivirus integration. J. Virol. 74 (2000) 11278-11285
12. Ariumi Y., Turelli P., Masutani M., and Trono D. DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration. J. Virol. 79 (2005) 2973-2978
13. Kilzer J.M., Stracker T., Beitzel B., Meek K., Weitzman M., and Bushman F.D. Roles of host cell factors in circularization of retroviral DNA. Virology 314 (2003) 460-467
14. Miskey C., Papp B., Mates L., Sinzelle L., Keller H., Izsvak Z., and Ivics Z. The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends. Mol. Cell. Biol. 27 (2007) 4589-4600
15. Liu D., Bischerour J., Siddique A., Buisine N., Bigot Y., and Chalmers R. The human SETMAR protein preserves most of the activities of the ancestral Hsmar1 transposase. Mol. Cell. Biol. 27 (2007) 1125-1132
16. Cordaux R., Udit S., Batzer M.A., and Feschotte C. Birth of a chimeric primate gene by capture of the transposase gene from a mobile element. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 8101-8106