Impaired response to interferon-γ in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric oxide

British Journal of Pharmacology

Volumn 132, Issue 2, 2001, Pages 419-426

  Llovera, Marta ^a   Pearson, Jeremy D ^a   Moreno, Carlos ^a   Riveros Moreno, Valentina ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Endotoxin; Interferon ; Macrophage; Nitric oxide; Nitrotyrosine; Peroxynitrite

Indexed keywords

ENDOTOXIN; GAMMA INTERFERON; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; STAT1 PROTEIN; TYROSINE;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NEGATIVE FEEDBACK; NITRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

EID: 0035129270     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703838     Document Type: Article

References (48)

1. iNOS expression and nitrotyrosine formation in the myocardium in response to inflammation is controlled by the interferon regulatory transcription factor 1
2. Activation of the inducible form of nitric oxide synthase in the brains of patients with multiple sclerosis
3. Potentiation of nitric oxide synthase expression by superoxide in interleukin 1β-stimulated rat mesangial cells
4. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
5. Oxidative chemistry of peroxynitrite
6. Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry
7. L-arginine transport is increased in macrophages generating nitric oxide
8. Nitric oxide as a competitive inhibitor of oxygen consumption in the mitochondrial respiratory chain
9. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite
10. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signalling proteins
11. Formation of nitric-oxide derived inflammatory oxidants by myeloperoxidase in neutrophils
12. Nitric oxide reversibly inhibits the epidermal growth factor receptor tyrosine kinase
13. Inactivation of tissue inhibitor metalloproteinase-1 by peroxynitrite
14. 2-terminal kinase
15. Two-dimensional polyacrylamide gel elctrophoresis with immobilized pH gradients in the first dimension (IPG-Dalt): The state of the art and the controversy of vertical versus horizontal systems
16. Effects of peroxynitrite-induced protein modifications on tyrosine phosphorylation and degradation
17. Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury
18. What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo?
19. Induction of nitric oxide synthase in asthma
20. L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells
21. Signalling through the hematopoietic cytokine receptors
22. Peroxynitrite formation from macrophage-derived nitric oxide
23. Expression of inducible nitric oxide synthase and formation of nitric oxide by alveolar macrophages: An interspecies comparison
24. Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients
25. Interleukin-4 stimulates cGMP production by IFN-gamma-activated human monocytes. Involvement of the nitric oxide synthase pathway
26. 2 peptide
27. Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages
28. Peroxynitrite modulates tyrosine phosphorylation and phosphoinositide signalling in human neuroblastoma SH-SY5Y cells: Attenuated effects ill human 1321N1 astrocytoma cells
29. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumour cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide
30. Inhibition of nitric oxide synthesis enhances the expression of inducible nitric oxide synthase mRNA and protein in a model of chronic liver inflammation
31. Tyrosine nitration of c-SRC tyrosine kinase in human pancreatic ductal adenocarcinoma
32. Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta stimulated rat mesangial cells
33. Role of nitric oxide synthesis in macrophage antimicrobial activity
34. Comparative resistance of the 20S and 26S proteasome to oxidative stress
35. Inhibition of NF-κB and HIV-1 long terminal repeat transcriptional activation by inducible nitric oxide synthase 2 activity
36. Oxidative stress: From basic research to clinical application
37. Widespread peroxynitrite-mediated damage in Alzheimer's disease
38. Biochemistry of nitric oxide and its redox-activated forms
39. Rapid and irreversible inactivation of protein tyrosine phosphatases PTP1B, CD45, and LAR by peroxynitrite
40. Cytokine signalling through nonreceptor protein tyrosine kinases
41. Peroxynitrite inhibits glutamate transporter subtypes
42. Nitrotyrosine formation after activation of murine macrophages with mycobacteria and mycobacterial lipoarabinomannan
43. Accumulation of nitrotyrosine on the SERCA2a isoform of SR Ca-ATPase of rat skeletal muscle during aging: A peroxynitrite-mediated process?
44. G-monomethylL-arginine
45. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
46. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages
47. Interleukin 1β decreases prostacyclin synthase activity in rat mesangial cells via endogenous peroxynitrite formation