Respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate in guinea pigs: Comparison with trimellitic anhydride

Inhalation Toxicology

Volumn 11, Issue 3, 1999, Pages 187-214

  Pauluhn, Jürgen ^a   Dearman, R ^b   Doe, J ^b   Hext, P ^b   Landry, T D ^c  

^a BAYER AG   (Germany)

^b ASTRAZENECA   (United Kingdom)

^c DOW CHEMICAL COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0032895721     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/089583799197140     Document Type: Article

References (54)

1. Backman, K. S., Shaughnessy, M. A., Harris, K. E., and Grammer, L. C. 1996. Total serum IgE in trimellitic anhydride-induced asthma. Journal of Occupational and Environmental Medicine 38:347-351.
2. Baur, X. 1995. Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J. Allergy Clin. Immunol. 95:1004-1010.
3. Blaikie, L., Morrow, T., Wilson, A. P., Hext, P., Hartop, P. J., Rattray, N. J., Woodcock, D., and Botham, P. A. 1995. A two-centre study for the evaluation and validation of an animal model for the assessment of the potential of small molecular weight chemicals to cause respiratory allergy. Toxicology 96:37-50.
4. Bos, P. M. J., Zwart, A., Reuzel, J., and Bragt, P. C. 1992. Evaluation of sensory irritation test for the assessment of occupational health risk. Crit. Rev. Toxicol. 21:423-450.
5. Botham, P. A., Hext, P. M., Rattray, N. J., Walsh, S. T., and Woodcock, D. R. 1988. Sensitization of guinea-pigs by inhalation exposure to low-molecular-weight chemicals. Toxicol. Lett. 41:159-173.
6. Botham, P. A., Rattray, N. J., Woodcock, D. R., Walsh, S. T., and Hext, P. 1989. The induction of respiratory allergy in guinea pigs following i.d. injection of trimellitic anhydride. A comparison of response to 2,4-dinitrochlorobenzene. Toxicol. Lett. 47:25-39.
7. Briatico-Vangosa, C., Braun, C. J. L., Cookman, G., Hofmann, T., Kimber, I., Loveless, S. E., Morrow, T., Pauluhn, J., Sørensen, T., and Niessen, H. J. 1994. Review. Respiratory allergy: Hazard identification and risk assessment. Fundam. Appl. Toxicol. 23:145-158.
8. Dodd, D. E., Fowler, E. H., Snellings, W. M., Pritts, I. M., and Baron, R. L. 1986. Acute inhalation studies with methyl isocyanate vapor. Fundam. Appl. Toxicol. 6:747-755.
9. Dunlap, K. L., Sandridge, R. L., and Keller, J. 1976. Determination of isocyanates in working atmosphere by high performance liquid chromatography. Anal. Chem. 48:497-499.
10. Gad, S. C., and Weil, C. S. 1982. Statistics for toxicologists. Principles and methods of toxicology, ed. A. W. Hayes, p. 280. New York: Raven Press.
11. Griffiths-Johnson, D. A., and Karol, M. H. 1991. Validation of a non-invasive technique to assess development of airway hyperreactivity in an animal model of immunologic respiratory hypersensitivity. Toxicology 65:283-294.
12. Hayes, J. P., and Newman-Taylor, A. J. 1995. In vivo models of occupational asthma due to low molecular weight chemicals. Occup. Environ. Med. 52:539-543.
13. Hayes, J. P., Daniel, H. R., Tee, R. D., Barnes, P. J., Newman-Taylor, A. J., and Chung, K. F. 1990. The effect of free trimellitic anhydride dust on airway responses in guinea pigs sensitised to the free hapten. Eur. Respir. J. 3:(Suppl. 10):340S.
14. Hayes, J. P., Daniel, H. R., Tee, R. D., Barnes, P. J., Chung, K. F., and Newman-Taylor, A. J. 1992a. Specific immunological and bronchopulmonary responses following intradermal sensitization to free trimellitic anhydride in guinea-pigs. Clin. Exp. Allergy 22:694-700.
15. Hayes, J. P., Daniel, H. R., Tee, R. D., Barnes, P. J., Newman-Taylor, A. J., and Chung, K. F. 1992b. Bronchial hyperreactivity after inhalation of trimellitic anhydride dust in guinea pigs after intradermal sensitization to the free hapten. Am. Rev. Respir. Dis. 146:1311-1314.
16. Hayes, J. P., Lotvall, J. O., Barnes, P. J., Newman-Taylor, A. J., and Chung, K. F. 1992c. Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea pigs. Br. J. Pharmacol. 106:828-832.
17. Huang, J., Aoyama, K., and Ueda, A. 1993. Experimental study on respiratory sensitivity to inhaled toluene diisocyanate. Arch. Toxicol. 67:373-378.
18. Karol, M. H. 1983. Concentration-dependent immunologic response to toluene diisocyanate (TDI) following inhalation exposure. Toxicol. Appl. Pharmacol. 68:229-241.
19. Karol, M. H. 1988. The development of an animal model for TDI asthma. Bull. Eur. Physiopathol. Respir. 23:571-576.
20. Karol, M. H. 1994. Animal models of occupational asthma. Eur. Respir. J. 7:555-568.
21. Karol, M. H., and Thorne, P. S. 1988. Respiratory hypersensitivity and hyperreactivity: implications for assessing allergic responses. In Toxicology of the lung, eds. D. E. Gardner, J. D. Crapo, and E. J. Massaro, pp. 427-448. New York: Raven Press.
22. Keskinen, H., Tupasela, O., Tiikkainen, U., and Norman, H. 1988. Experience of specific IgE in asthma due to diisocyanates. Clin. Allergy 18:597-604.
23. Kimber, I., Bernstein, I. L., Karol, M. H., Robinson, M. K., Sarlo, K., and Selgrade, M. J. K. 1996. Workshop overview: Identification of respiratory allergens. Fundam. Appl. Toxicol. 33:1-10.
24. Levine, S. P., Hillig, K. J. D., Dharmarajan, V., Spence, M. W., and Baker, M. D. 1995. Critical review of methods of sampling, analysis, and monitoring for TDI and MDI. Am. Ind. Hyg. Assoc. J. 56:581-589.
25. Lillie, R. D., and Fullmer, H. M. 1976. Histopathologic technique and practical histochemistry, 4th ed., Table 7-6, p. 206. New York: McGraw-Hill.
26. Liu, B. Y. H., Whitby, K. T., and Yu, H. H. S. 1966. A condensation aerosol generator for producing monodispersed aerosols in the size range, 0.036μ to 1.3μ. J. Rech. Atm. 99:397-406.
27. Lushniak, B. D., Reh, C. M., Bernstein, D. I., and Gallagher, J. S. 1998. Indirect assessment of 4,4′-diphenylmethane diisocyanate (MDI) exposure by evaluation of specific humoral immune responses to MDI conjugated to human serum albumin. Am. J. Ind. Med. 33:471-477.
28. McGrath, K. G., Zeiss, C., and Patterson, R. 1983. Allergic reactions to industrial chemicals. Clin. Immunol. Rev. 2:1-58.
29. Murlas, C. G., and Roum, J. H. 1985. Sequence of pathologic changes in the airway mucosa of guinea-pigs during ozone-induced bronchial hyperreactivity. Am. Rev Respir. Dis. 131:314-320.
30. Newman-Taylor, A. J., Venables, K. M., Durham, S. R., Graneek, B. J., and Topping, M. D. 1987. Acid anhydrides and asthma. Int. Arch. Allergy Clin. Immunol. 82:435-439.
31. Obata, H., Tao, Y., Kido, M., Nagata, N., Tanaka, I., and Kuroiwa, A. 1992. Guinea-pig model of immunologic asthma induced by inhalation of trimellitic anhydride. Am. Rev. Respir. Dis. 146: 1553-1558.
32. Patterson, R., Addington, W., Banner, A. S., Byron, G. E., Franco, M., Herbert, F. A., Nicotra, M. B., Pruzansky, J. J., Rivera, M., Roberts, M., Yawn, D., and Zeiss, R. 1979. Antihapten antibodies in workers exposed to trimellitic anhydride fumes: A potential immunopathogenic mechanism for the trimellitic anhydride pulmonary disease-anemia syndrome. Am. Rev. Respir. Dis. 120:1259-1267.
33. Pauluhn, J. 1994a. Assessment of chemicals for their potential to induce respiratory allergy in guinea pigs: A comparison of different routes of induction and confounding effects due to pulmonary hyperreactivity. Toxicol. In Vitro 8:981-985.
34. Pauluhn, J. 1994b. Test methods for respiratory sensitisation. In Use of mechanistic information in risk assessment, eds. H. M. Bolt, B. Hellman, and L. Dencker. Arch. Toxicol. Suppl. 16:77-86.
35. Pauluhn, J. 1994c. Validation of an improved nose-only exposure system for rodents. J. Appl. Toxicol. 14:5-62.
36. Pauluhn, J. 1997. Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene diisocyanate: Improvements on analysis of response. Fundam. Appl. Toxicol. 40:211-219.
37. Pauluhn, J., and Eben, A. 1991. Validation of a non-invasive technique to assess immediate or delayed onset of airway hypersensitivity in guinea-pigs. J. Appl. Toxicol. 11:423-431.
38. Pauluhn, J., and Mohr, U. 1994. Assessment of respiratory hypersensitivity in guinea-pigs sensitized to diphenylmethane-4,4′-diisocyanate (MDI) and challenged with MDI, acetylcholine or MDI-albumin conjugate. Toxicology 92:53-74.
39. Pretolani, M., and Vargaftig, B. B. 1993. Commentary: From lung hypersensitivity to bronchial hyperreactivity. Biochem. Pharmacol. 45:791-800.
40. Rapaport, E., and Weinstock, S. E. 1955. A generator for homogeneous aerosols. Experimentia 11:63-64.
41. Rattray, N. J., Botham, P. A., Hext, P. M., Woodcock, D. R., Fielding, I., Dearman, R. J., and Kimber, I. 1994. Induction of respiratory hypersensitivity to diphenylmethane-4,4′-diisocyanate (MDI) in guinea pigs. Influence of route of exposure. Toxicology 88:15-30.
42. Sarlo, K., and Clark, E. D. 1992. A tier approach for evaluating the respiratory allergenicity of low-molecular-weight chemicals. Fundam. Appl. Toxicol. 18:107-114.
43. Sarlo, K., and Karol, M. H. 1994. Guinea pig predictive tests for respiratory allergy. In Immunotoxicology and immunopharmacology, 2nd ed., eds. J. H. Dean, M. I. Luster, A. E. Munson, and I. Kimber, pp. 703-720. New York: Raven Press.
44. Sugawara, Y., Okamoto, Y., Sawahata, T., and Tanaka, K. 1993. An asthma model developed in the guinea pig by intranasal application of 2,4-toluene diisocyanate. Int. Arch. Allergy Immunol. 101: 95-101.
45. Sun, J., and Chung, K. F. 1997. Interaction of ozone exposure with airway hyperresponsiveness and inflammation induced by trimellitic anhydride in sensitized guinea pigs. J. Toxicol. Environ. Health 51:77-87.
46. Tan, W. C., and Bethel, R. A. 1992. The effect of platelet activating factor antagonist on ozone-induce airway inflammation and bronchial hyperresponsiveness in guinea pigs. Am. Rev. Respir. Dis. 146:916-922.
47. Tansar, A. R., Bourke, M. P., and Blandford, A. G. 1973. Isocyanate asthma: Respiratory symptoms caused by diphenylmethane diisocyanate. Thorax 28:596-600.
48. Vandenplas, O., Malo, J.-L., Saetta, M., Mapp, C. E., and Fabbri, L. M. 1993. Occupational asthma and extrinsic alveolitis due to isocyanates: Current status and perspectives. Br. J. Ind. Med. 50: 213-228.
49. Venables, K. M. 1989. Low molecular weight chemicals, hypersensitivity and direct toxicity: The acid anhydrides. Br. J. Med. 46:222-232.
50. Verdier, F., Chazal, I., and Descotes, J. 1994. Review paper: Anaphylaxis models in the guinea pig. Toxicology 93:55-61.
51. Welinder, H., Zhang, X., Gustavsson, C., Björk, B., and Skerfving, S. 1995. Structure-activity relationship of organic anhydrides as antigens in an animal model. Toxicology 103:127-136.
52. Weyel, D. A., and Schaffer, R. B. 1985. Pulmonary and sensory irritation of diphenylmethane-4,4′- and dicyclohexylmethane-4,4′-diisocyanate. Toxicol. Appl. Pharmacol. 77:427-433.
53. Zammit-Tabona, M., Sherkin, M., Kijek, K., Chan, H., and Chan-Yeung, M. 1983. Asthma caused by diphenylmethane diisocyanate in foundry workers. Clinical, bronchial provocation and immunologic studies. Am. Rev. Respir. Dis. 128:226-230.
54. Zeiss, C. R., Kanellakes, T. M., Bellone, J. D., Levitz, D., Pruzansky, J. J., and Patterson, R. 1980. Immunoglobulin E-mediated asthma and hypersensitivity pneumonitis with precipitating anti-hapten antibodies due to diphenylmethane diisocyanate (MDI) exposure. J. Allergy Clin. Immunol. 65:346-352.