Hepatocellular Carcinoma in Cirrhotic Liver Disease. Functional Computed Tomography With Perfusion Imaging in the Assessment of Tumor Vascularization

Academic Radiology

Volumn 15, Issue 7, 2008, Pages 919-927

  Ippolito, Davide ^a   Sironi, Sandro ^a   Pozzi, Massimo ^a   Antolini, Laura ^a   Ratti, Laura ^a   Alberzoni, Chiara ^a   Leone, Eugenio Biagio ^a   Meloni, Franca ^b   Valsecchi, Maria Grazia ^a   Fazio, Ferruccio ^a,c,d  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b H Vimercate ^*  (Italy)

^c INSTITUTE OF MOLECULAR BIOIMAGING AND PHYSIOLOGY   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

blood flow; Computed tomography; contrast enhanced ultrasound; functional computed tomography; liver tumor; perfusion computed tomography

Indexed keywords

IOBITRIDOL; SONOVUE; XENETIX 350;

ADULT; AGED; ARTERY PERFUSION; ARTICLE; BLOOD VOLUME; CALCULATION; CANCER SIZE; CLINICAL ARTICLE; COMPUTED TOMOGRAPHY SCANNER; CONTRAST ECHOCARDIOGRAPHY; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DISEASE CLASSIFICATION; FEMALE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMAGE ENHANCEMENT; LIVER BLOOD FLOW; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER PERFUSION; MALE; MICROCIRCULATION; MULTIDETECTOR COMPUTED TOMOGRAPHY; PARAMETER; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCREENING TEST; TUMOR VASCULARIZATION; UNIVARIATE ANALYSIS; WILCOXON SIGNED RANKS TEST;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; CONTRAST MEDIA; FEMALE; HUMANS; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOLIPIDS; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; STATISTICS, NONPARAMETRIC; SULFUR HEXAFLUORIDE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 47749148381     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2008.02.005     Document Type: Article

References (27)

1. Miles K.A., Hayball M., and Dixon A.K. Colour perfusion imaging: A new application of computed tomography. Lancet 337 (1991) 643-645
2. Itai Y., and Matsui O. Blood flow and liver imaging. Radiology 202 (1997) 306-314
3. Matsui O., Kadoya M., Kameyama T., et al. Benign and malignant nodules in cirrhotic livers: Distinction based on blood supply. Radiology 178 (1991) 493-497
4. Park Y.N., Yang C.P., Fernandez G.J., Cubukcu O., Thung S.N., and Theise N.D. Neoangio-genesis and sinusoidal capillarization in dysplastic nodules of the liver. Am J Surg Pathol 22 (1998) 656-662
5. Pluda J.M. Tumor-associated angiogenesis: Mechanisms, clinical applications and therapeutic strategies. Semin Oncol 24 (1997) 203-218
6. Pandharipande P.V., Krinsky G.A., Rusinek H., and Lee V.S. Perfusion imaging of the liver: Current challenges and future goals. Radiology 234 (2005) 661-673
7. Miles K.A., Hayball M.P., and Dixon A.K. Functional images of hepatic perfusion obtained with dynamic CT. Radiology 188 (1993) 405-411
8. Miles K.A., and Griffiths M.R. Perfusion CT: A worthwhile enhancement?. Br J Radiol 76 (2003) 220-231
9. Miles K.A. Perfusion CT for the assessment of tumour vascularity: Which protocol?. Br J Radiol 76 (2003) 36-42
10. Miles K.A., Charnsangavej C., Lee F.T., Fishman E.K., Horton K., and Lee T.Y. Application of CT in the investigation of angiogenesis in oncology. Acad Radiol 7 (2000) 840-850
11. Cuenod C.A., Leconte I., Siauve N., et al. Deconvolution technique for measuring tissue perfusion by dynamic CT: Application to normal and metastatic liver. Acad Radiol 9 (2002) 205-211
12. Van Beers B.E., Leconte I., Materne R., Smith A.M., Jamart J., and Horsmans Y. Hepatic perfusion parameters in chronic liver disease: Dynamic CT measurements correlated with disease severity. AJR Am J Roentgenol 176 (2001) 667-673
13. Bruix J., Sherman M., Llovet J.M., et al. Clinical management of hepatocellular carcinoma: Conclusions of the Barcelona-2000 EASL Conference. J Hepatol 35 (2001) 421-430
14. Bruix J., and Sherman M. Management of hepatocellular carcinoma. Hepatology 42 (2005) 337-356
15. Hollander M., and Wolfe D.A. Nonparametric Statistical Methods. 2nd ed. (1999), John Wiley and Sons, New York
16. Tsushima Y., Funabasama S., and Aoki J. Quantitative perfusion map of malignant liver tumors created from dynamic computed tomography data. Acad Radiol 11 (2004) 215-223
17. Passe T.J., Bluemke D.A., and Siegelman S.S. Tumor angiogenesis: Tutorial on implications for imaing. Radiology 203 (1997) 593-600
18. Li W.W. Tumor angiogenesis: Molecular pathology, therapeutic targeting, and imaging. Acad Radiol 7 (2000) 800-811
19. Hayashi M., Matsui O., Ueda K., et al. Correlation between the blood supply and grade of malignancy of hepatocellular nodules associated with liver cirrhosis: Evaluation by CT during intraarterial injection of contrast medium. AJR Am J Roentgenol 172 (1999) 969-976
20. Kim C.K., Lim J.H., Park C.K., et al. Neoangiogenesis and sinusoidal capillarization in hepatocellular carcinoma: Correlation between dynamic CT and density of tumor microvessels. Radiology 237 (2005) 529-534
21. Fournier L.S., Cuenod C.A., de Bazelaire C., et al. Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol 14 (2004) 2125-2133
22. Kan Z., Kobayashi S., Phongkitkarun S., and Charnsangavej C. Functional CT quantification of tumor perfusion after transhepatic arterial embolization in a rat model. Radiology 1 (2005) 144-150
23. Kan Z., Phongkitkarun S., Kobayashi S., et al. Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology 237 (2005) 151-158
24. Swensen S.J., Brown L.R., Colby T.V., Weaver A.L., and Midthun D.E. Lung nodule enhancement at CT: Prospective findings. Radiology 201 (1996) 447-455
25. Zhang M., and Kono M. Solitary pulmonary nodules: Evaluation of blood flow patterns with dynamic CT. Radiology 205 (1997) 471-478
26. Dugdale P.E., Miles K.A., Kelly B.B., Bunce I.H., and Legget D.A.C. CT measurements of perfusion and permeability within lymphoma masses: Relationship to grade, activity and chemotherapeutic response. J Comput Assist Tomogr 23 (1999) 540-547
27. Boone J.M. Multidetector CT: Opportunities, challenges, and concerns associated with scanners with 64 or more detector rows. Radiology 241 (2006) 334-337