The genetics of the Rhesus blood group system

Blood Transfusion

Volumn 5, Issue 2, 2007, Pages 50-57

  Flegel, Willy A ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Blood group; Molecular diagnostic; Pregnancy; Rhesus; Transfusion

Indexed keywords

RHESUS ANTIGEN; RHESUS D ANTIBODY;

ALLELE; AMINO ACID SUBSTITUTION; BLOOD DONOR; BLOOD GROUP ABO SYSTEM; BLOOD GROUP RHESUS SYSTEM; CONFERENCE PAPER; ERYTHROCYTE MEMBRANE; FRAMESHIFT MUTATION; GENE AMPLIFICATION; GENE CONVERSION; GENE DELETION; GENE DUPLICATION; HAPLOTYPE; HUMAN; HUMAN GENOME PROJECT; HYBRIDIZATION; IMMUNIZATION; MISSENSE MUTATION; MOLECULAR GENETICS; MUTATIONAL ANALYSIS; NONSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; PREGNANCY; PREGNANT WOMAN; PRENATAL DIAGNOSIS; PROPHYLAXIS; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 47749107911     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (32)

1. Flegel WA, Wagner FF. Blutgruppen: Alloantigene auf Erythrozyten. In: Mueller-Eckhardt C, Kiefel V, eds.: Transfusionsmedizin. Berlin, Berlin Springer; 2003: p. 145-85.
2. Howard H, Martlew V, McFadyen I, et al. Consequences for fetus and neonate of maternal red cell allo-immunisation. Arch Dis Child Fetal Neonatal Ed 1998; 78: F62-6.
3. Filbey D, Hanson U, Wesstrom G. The prevalence of red cell antibodies in pregnancy correlated to the outcome of the newborn: a 12 year study in central Sweden. Acta Obstet Gynecol Scand 1995; 74: 687-92.
4. Cheong YC, Goodrick J, Kyle PM, Soothill P. Management of anti-Rhesus-D antibodies in pregnancy: a review from 1994 to 1998. Fetal Diagn Ther 2001; 16: 294-8.
5. Bundesärztekammer, Paul-Ehrlich-Institut. Richtlinien zur Gewinnung von Blut und Blutbestandteilen und zur Anwendung von Blutprodukten (Hämotherapie) - Gesamtnovelle 2005. Bundesanzeiger 2005; 57(209a): 4-35.
6. Cichon S, Freudenberg J, Propping P, Nöthen MM. Variabilität im menschlichen Genom. Dtsch Arztebl 2002; 99: 3091-101.
7. Wagner FF, Eicher NI, Jorgensen JR, et al. DNB: a partial D with anti-D frequent in Central Europe. Blood 2002; 100: 2253-6. .
8. Wagner FF, Flegel WA. RHCE represents the ancestral RH position, while RHD is the duplicated gene. Blood 2002; 99: 2272-3.
9. Wagner FF, Flegel WA. RHD gene deletion occurred in the Rhesus box. Blood 2000; 95: 3662-8.
10. Wagner FF, Frohmajer A, Flegel WA. RHD positive haplotypes in D negative Europeans. BMC Genet 2001; 2: 10.
11. Wagner FF, Gassner C, Müller TH, et al. Molecular basis of weak D phenotypes. Blood 1999; 93: 385-93.
12. Shao CP, Maas JH, Su YQ, et al. Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese. Vox Sang 2002; 83: 156-61.
13. Propping P. Genetische Diagnostik vor dem Hintergrund von Millionen Polymorphismen. Dtsch Arztebl 2004; 101: 3100-1.
14. Flegel WA, Wagner FF, Müller TH, Gassner C. Rh phenotype prediction by DNA typing and its application to practice. Transfus Med 1998; 8: 281-302.
15. Wagner FF, Kasulke D, Kerowgan M, Flegel WA. Frequencies of the blood groups ABO, Rhesus, D category VI, Kell, and of clinically relevant high-frequency antigens in South-Western Germany. Infusionsther Transfusionsmed 1995; 22: 285-90.
16. Wagner FF, Gassner C, Müller TH, et al. Three molecular structures cause Rhesus D category VI phenotypes with distinct immunohematologic features. Blood 1998; 91: 2157-68.
17. Lippert H-D, Flegel WA. Kommentar zum Transfusionsgesetz (TFG) und den Hämotherapie-Richtlinien. Heidelberg: Springer 2002.
18. Flegel WA. How I manage donors and patients with a weak D phenotype. Curr Opin Hematol 2006; 13: 476-83.
19. Wagner FF, Frohmajer A, Ladewig B, et al. Weak D alleles express distinct phenotypes. Blood 2000; 95: 2699-708.
20. Garratty G. Do we need to be more concerned about weak D antigens? Transfusion 2005; 45: 1547-51.
21. Gemeinsamer Bundesausschuss. Richtlinien des Bundesausschusses der Ärzte und Krankenkassen über die ärztliche Betreuung während der Schwangerschaft und nach der Entbindung. Bundesanzeiger 1986; 60 a (Beilage), zuletzt geändert: Bundesanzeiger 2003; 126: 14.906.
22. Lo YMD, Hjelm NM, Fidler C, et al. Prenatal diagnosis of fetal RhD status by molecular analysis of maternal plasma. N Engl J Med 1998; 339: 1734-8.
23. Bianchi DW, Avent ND, Costa JM, van der Schoot CE. Noninvasive prenatal diagnosis of fetal Rhesus D: ready for prime(r) time. Obstet Gynecol 2005; 106: 841-4.
24. Wagner T, Körmöczi GF, Buchta C, et al. Anti-D immunization by DEL red blood cells. Transfusion 2005; 45: 520-6.
25. Gassner C, Doescher A, Drnovsek TD, et al. Presence of RHD in serologically D-, C/E+ individuals: a European multicenter study. Transfusion 2005; 45: 527-38.
26. Yasuda H, Ohto H, Sakuma S, Ishikawa Y. Secondary anti-D immunization by DEL red blood cells. Transfusion 2005; 45: 1581-4.
27. Flegel WA. Homing in on D antigen immunogenicity. Transfusion 2005; 45: 466-8.
28. Agre P, Saboori AM, Asimos A, Smith BL. Purification and partial characterization of the Mr 30,000 integral membrane protein associated with the erythrocyte Rh(D) antigen. J Biol Chem 1987; 262: 17497-503.
29. Marini AM, Matassi G, Raynal V, et al. The human Rhesus-associated RhAG protein and a kidney homologue promote ammonium transport in yeast. Nat Genet 2000; 26: 341-4.
30. Flegel WA. The Rhesus Site. DRK-Blutspendedienst Baden-Württemberg- Hessen. 1998-2007. www.uniulm. de/~wflegel/RH/
31. Müller TH, Hallensleben M, Schunter F, Blasczyk R. Molekulargenetische Blutgruppendiagnostik. Dtsch Arztebl 2001; 98: A317-22.
32. Northoff H, Flegel WA. Genotyping and phenotyping: the two sides of one coin. Infusionsther Transfusionsmed 1999; 26: 5.