Blast cells with nuclear extrusions in the form of micronuclei are associated with MYC amplification in acute myeloid leukemia

Cancer Genetics and Cytogenetics

Volumn 185, Issue 1, 2008, Pages 32-36

  Villa, Olaya ^a,b   Salido, Marta ^a,c   Pérez Vila, María Encarnación ^a,c   Ferrer, Ana ^a,c   Arenillas, Leonor ^a,c   Pedro, Carmen ^a   Espinet, Blanca ^a,c   Corzo, Cristina ^a   Serrano, Sergi ^a   Woessner, Soledad ^c   Florensa, Lourdes ^a,c   Solé, Francesc ^a,c  

^a HOSPITAL DEL MAR   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c Del Mar University   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; ETOPOSIDE; IDARUBICIN; MERCAPTOPURINE;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLAST CELL; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CANCER CLASSIFICATION; CANCER REGRESSION; CASE REPORT; CELL NUCLEUS; CELL STRUCTURE; CHROMATIN; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERPHASE; LABORATORY TEST; MALE; MICRONUCLEUS; ONCOGENE MYC; PRIORITY JOURNAL; TREATMENT RESPONSE;

AGED; CELL NUCLEUS; CHROMATIN; CHROMOSOME ABERRATIONS; CHROMOSOME PAINTING; CYTOGENETIC ANALYSIS; FATAL OUTCOME; FOLLOW-UP STUDIES; GENE AMPLIFICATION; GENES, MYC; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; REMISSION INDUCTION; TIME FACTORS; TRISOMY;

EID: 47749101572     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.04.014     Document Type: Article

References (9)

1. Shimizu N., Itoh N., Utiyama H., and Wahl G.M. Selective entrapment of extrachromosomally amplified DNA by nuclear budding and micronuclei during S phase. J Cell Biol 140 (1998) 1307-1320
2. Arnaud B., Douet-Guilbert N., Morel F., Le Bris M.J., Herry A., Banzakour S., Bourquard P., Morice P., Le Calvez G., Marion V., Abgrall J.F., Berthou C., and De Braekeleer M. Screening by fluorescence in situ hybridization for MLL status at diagnosis in 239 unselected patients with acute myeloblastic leukemia. Cancer Genet Cytogenet 161 (2005) 110-115
3. Storlazzi C.T., Fioretos T., Surace C., Lonoce A., Mastrorilli A., Strömbeck B., D'Addabyo P., Iacovelli F., Minervini C., Aventin A., Dastugue N., Fonastsch C., Hagemeijer A., Jotterand M., Mühlematter D., Lafage-Pochitaloff M., Nguyen-Khac F., Schoch C., Slovak M.L., Smith A., Solé F., Van Roy N., Johansson B., and Rocchi M. MYC-containing double minutes in hematologic malignancies: evidence in favor of the episome model and exclusion of MYC as the target gene. Hum Molec Genet 15 (2006) 933-942
4. Von Hoff D.D., McGill J.R., Forseth B.J., Davison K.K., Bradley T.P., Van Devanter D.R., and Wahl G.M. Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity. Proc Natl Acad Sci USA 89 (1992) 8165-8169
5. Rodon N., Solé F., Espinet B., Salido M., Zamora L., Cigudosa J.C., Woessner S., and Florensa L. A new case of acute nonlymphocytic leukemia (French-American-British subtype M1) with double minutes and c-MYC amplification. Cancer Genet Cytogenet 132 (2002) 161-164
6. Asker C., Mareni C., Coviello D., Ingvarsson S., Sessarego M., Origone P., Klein G., and Sumeigi J. Amplification of MYC and pvt-1 homologous sequences in acute nonlymphatic leukemia. Leuk Res 12 (1988) 523-527
7. Golovleva I., Hultdin J., Roos G., Wahlin A., and Holmgren G. Co-existence of pseudo-Chediak-Higashi anomaly and double minutes containing MYC oncogene in three patients with AML M2. Leukemia 16 (2002) 152-154
8. Frater J.L., Hoover R.G., Bernreuter K., and Batanian J.R. Deletion of MYC and presence of double minutes with MYC amplification in a morphologic acute promyelocytic leukemia-like case lacking RARA rearrangement: could early exclusion of double-minutes chromosomes be a prognostic factor?. Cancer Genet Cytogenet 166 (2006) 139-145
9. Valent A., Bénard J., Clausse B., Barrois M., Valteau-Couanet D., Terrier-Lacombe M.J., Spengler B., and Bernheim A. In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei. Am J Pathol 158 (2001) 1579-1584