Deletion of MYC and presence of double minutes with MYC amplification in a morphologic acute promyelocytic leukemia-like case lacking RARA rearrangement: could early exclusion of double-minute chromosomes be a prognostic factor?

Cancer Genetics and Cytogenetics

Volumn 166, Issue 2, 2006, Pages 139-145

  Frater, John L ^a   Hoover, Richard G ^a   Bernreuter, Kristen ^c   Batanian, Jacqueline R ^a,b,c  

^a The Departments of Pathology   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Cardinal Glennon Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTARABINE; DAUNORUBICIN; HYBRID PROTEIN; MYC PROTEIN; PROMYELOCYTIC LEUKEMIA PROTEIN; PROTEIN; RAR ALPHA PROTEIN; RETINOIC ACID; SWOG 9710; UNCLASSIFIED DRUG; ONCOPROTEIN; RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA;

ACTINIC KERATOSIS; ACUTE GRANULOCYTIC LEUKEMIA; AGED; ARTICLE; BLOOD CELL COUNT; BLOOD CLOTTING DISORDER; BONE MARROW BIOPSY; CASE REPORT; CHROMOSOME 8Q; CHROMOSOME TRANSLOCATION; DISEASE EXACERBATION; DISSEMINATED INTRAVASCULAR CLOTTING; DOUBLE MINUTE CHROMOSOME; DRUG ERUPTION; DYSPNEA; EPISTAXIS; GENE AMPLIFICATION; GENE DELETION; GENE REARRANGEMENT; HUMAN; MALE; ONCOGENE MYC; PRIORITY JOURNAL; PROGNOSIS; PROMYELOCYTE; PROMYELOCYTIC LEUKEMIA; PROTEIN DEFECT; RNA TRANSLATION; ADULT; CHILD; CHROMOSOME 8; GENETICS; METAPHASE; MIDDLE AGED;

ADULT; AGED; AGED, 80 AND OVER; CHILD; CHROMOSOMES, HUMAN, PAIR 8; GENE AMPLIFICATION; GENE DELETION; GENE REARRANGEMENT; GENES, MYC; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; METAPHASE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PROGNOSIS; RECEPTORS, RETINOIC ACID;

EID: 33646848571     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2005.10.013     Document Type: Article

References (24)

1. Melnick A., and Licht J.D. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood 93 (1999) 3167-3215
2. O'Malley F., Rayeroux K., Cole-Sinclair M., Tong M., and Campbell L.J. MYC amplification in two further cases of acute myeloid leukemia with trisomy 4 and double minute chromosomes. Cancer Genet Cytogenet 109 (1999) 123-125
3. Thomas L., Stamberg J., Gojo I., Ning Y., and Rapoport A.P. Double minute chromosomes in monoblastic (M5) and myeloblastic (M2) acute myeloid leukemia: two case reports and a review of literature. Am J Hematol 77 (2004) 55-61
4. Brockman S.R., Paternoster S.F., Ketterling R.P., and Dewald G.W. New highly sensitive fluorescence in situ hybridization method to detect PML/RARA fusion in acute promyelocytic leukemia. Cancer Genet Cytogenet 145 (2003) 144-151
5. Sucic M., Zadro R., Burazer B., Labar B., Nemet D., Mrsic M., Aurer I., Mrsic S., Hitrec V., Boban D., Markovic-Glamocak M., Batinic D., Uzarevic B., and Stavljenic-Rukavina A. Acute promyelocytic leukemia M3: cytomorphologic, immunophenotypic, cytogenetic, and molecular variants. J Hematother Stem Cell Res 11 (2002) 941-950
6. Najfeld V., Chen A., Scalise A., Ambinder E.P., Fernandez G., and Waxman S. Myelodysplastic syndrome transforming to acute promyelocytic-like leukemia with trisomy and rearrangement of chromosome 11. Genes Chromosomes Cancer 10 (1994) 15-25
7. Nakata Y., Mori T., Yamazaki T., Suzuki T., Okazaki T., Kurosawa Y., et al. Acute myeloid leukemia with hypergranular cytoplasm accompanied by t(X;11)(q24;q23) and rearrangement of the MLL gene. Leuk Res 23 (1999) 85-88
8. Grimwade D., Biondi A., Mozziconacci M.J., Hagemeijer A., Berger R., Neat M., Howe K., Dastugue N., Jansen J., Radford-Weiss I., Lo Coco F., Lessard M., Hernandez J.M., Delabesse E., Head D., Liso V., Sainty D., Flandrin G., Solomon E., Birg F., and Lafage-Pochitaloff M. Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Francais de Cytogenetique Hematologique, Groupe de Francais d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action "Molecular Cytogenetic Diagnosis in Haematological Malignancies". Blood 96 (2000) 1297-1308
9. Slater R.M., von Drunen E., Kroes W.G., Weghuis D.O., van den Berg E., Smit E.M., van der Does-van den Berg A., van Wering E., Hahlen K., Carroll A.J., Raimondi S.C., and Beverloo H.B. t(7;12)(q36;p13) and t(7;12)(q32;p13)-translocations involving ETV6 in children 18 months of age or younger with myeloid disorders. Leukemia 15 (2001) 915-920
10. Zhang L., Mulvihill J.J., Kern W.F., McMinn J., and Li S. Duplication 15q as the sole anomaly in an acute promyelocytic leukemia patient without t(15;17). Cancer Genet Cytogenet 138 (2002) 17-21
11. Mitelman F, Johansson B, Mertens F, editors. Mitelman Database of Chromosome Aberrations in Cancer (2004). Available at: http://www.cgap.nci.gov/Chromosomes/Mitelman. Accessed July 10, 2004.
12. Mohamed A.N., Macoska J.A., Kallioniemi A., Kallioniemi O.P., Waldman F., Ratanatharathorn V., and Wolman S.R. Extrachromosomal gene amplification in acute myeloid leukemia: characterization by metaphase analysis, comparative genomic hybridization, and semi-quantitative PCR. Genes Chromosomes Cancer 8 (1993) 185-189
13. Chim C.S., Lam C.C., Wong K.F., Man C., Kam S., and Kwong Y.L. Atypical blasts and bone marrow necrosis associated with near-triploid relapse of acute promyelocytic leukemia after arsenic trioxide treatment. Hum Pathol 33 (2002) 849-851
14. Gallagher R., Collins S., Trujillo J., McCredie K., Ahearn M., Tsai S., Metzgar R., Aulakh G., Ting R., Ruscetti F., and Gallo R. Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia. Blood 54 (1979) 713-733
15. Dalton Jr. W.T., Ahearn M.J., McCredie K.B., Freireich E.J., Stass S.A., and Trujillo J.M. HL-60 cell line was derived from a patient with FAB-M2 and not FAB-M3. Blood 71 (1988) 242-247
16. Streubel B., Valent P., Jager U., Edelhauser M., Wandt H., Wagner T., Buchner T., Lechner K., and Fonatsch C. Amplification of the MLL gene on double minutes, a homogeneously staining region, and ring chromosomes in five patients with acute myeloid leukemia or myelodysplastic syndrome. Genes Chromosomes Cancer 27 (2000) 380-386
17. Storlazzi C.T., Fioretos T., Paulsson K., Strombeck B., Lassen C., Ahlgren T., Juliusson G., Mitelman F., Rocchi M., and Johansson B. Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies. Hum Mol Genet 13 (2004) 1479-1485
18. Sambani C., Trafalis D.T., Vessalas G., Politis G., Peristeris P., Nakopoulou L., Giannopoulou J., Michaelidis C., Ayoutantis M., and Pantelias G.E. Trisomy 6 and double minute chromosomes in a case of chronic myelomonocytic leukemia. Cancer Genet Cytogenet 106 (1998) 180-181
19. Bruckert P., Kappler R., Scherthan H., Link H., Hagmann F., and Zankl H. Double minutes and c-MYC amplification in acute myelogenous leukemia: Are they prognostic factors?. Cancer Genet Cytogenet 120 (2000) 73-79
20. Shima H., Nakayasu M., Aonuma S., Sugimura T., and Nagao M. Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide. Proc Natl Acad Sci USA 86 (1989) 7442-7445
21. Haque M.M., Hirano T., Nakamura H., and Utiyama H. Granulocytic differentiation of HL-60 cells, both spontaneous and drug-induced, might require loss of extrachromosomal DNA encoding a gene(s) not c-MYC. Biochem Biophys Res Commun 288 (2001) 586-591
22. Shimizu N., Shimura T., and Tanaka T. Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei. Mutat Res 448 (2000) 81-90
23. Valent A., Benard J., Clausse B., Barrois M., Valteau-Couanet D., Terrier-Lacombe M.J., Spengler B., and Bernheim A. In vivo elimination of acentric double minutes containing amplified MYCN from neuroblastoma tumor cells through the formation of micronuclei. Am J Pathol 158 (2001) 1579-1584
24. Christacos N.C. Is the cryptic interstitial deletion of 8q24 surrounding MYC a common mechanism in the formation of double minute chromosome?. Cancer Genet Cytogenet 161 (2005) 90-92