Pharmacokinetics, dosage regimen and in vitro plasma protein binding of intramuscular levofloxacin in buffalo calves

Iranian Journal of Veterinary Research

Volumn 9, Issue 2, 2008, Pages 121-126

  Ram, D ^a   Dumka, V K ^a   Sharma, S K ^a   Sandhu, H S ^a  

^a GURU ANGAD DEV VETERINARY AND ANIMAL SCIENCES UNIVERSITY   (India)

Author keywords

Buffalo calves; Dosage; Intramuscular; Levofloxacin; Pharmacokinetics

Indexed keywords

EID: 47749100023     PISSN: 17281997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Aliabadi, FS and Lees, P (2001). Pharmacokinetics and pharmacodynamics of danofloxacin in serum and tissue fluids of goats following intravenous and intramuscular administration. Am. J. Vet. Res., 62: 1979-1989.
2. Aliabadi, FS; Landoni, MF and Lees, P (2003). Pharmacokinetics (PK), pharmacodynamics (PD) and PK-PD integration of danofloxacin in sheep biological fluids. Antimicrob. Agents Chemother., 47: 626-635.
3. Arret, B; Johnson, DP and Kirshbaum, A (1971). Outline of details for microbiological assay of antibiotics: second revision. J. Pharm. Sci., 60: 1689-1694.
4. Baggot, JD (1977). Principles of pharmacokinetics. Principles of drug disposition in domestic animals. 1st Edn., Philadelphia, W. B. Saunders Co., PP: 144-189.
5. Bakken, JS (2004). The fluoroquinolones: how long will their utility last? Scand. J. Infect. Dis., 36: 85-92.
6. Chulavatnatol, S; Chindavijak, B; Vibhagool, A; Wananukul, W; Sriapha, C and Sirisangtragul, C (1999). Pharmacokinetics of levofloxacin in healthy Thai male volunteers. J. Med. Assoc. Thai., 82: 1127-1135.
7. Davis, R and Bryson, HM (1994). Levofloxacin: a review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drugs. 47: 677-700.
8. Destache, CJ; Pakiz, CB; Larsen, C; Owens, H and Dash, AK (2001). Cerebrospinal fluid penetration and pharmacokinetics of levofloxacin in an experimental rabbit meningitis model. J. Antimicrob. Chemother., 47: 611.
9. Dumka, VK and Srivastava, AK (2006). Pharmacokinetics, urinary excretion and dosage regimen of levofloxacin following a single intramuscular administration in cross bred calves. J. Vet. Sci., 7: 333-337.
10. Edelstein, PH; Edelstein, MA; Lehr, KH and Ren, J (1996). In vitro activity of levofloxacin against clinical isolates of Legionella spp, its pharmacokinetics in guinea pigs, and use in experimental Legionella pneumophila pneumonia. J. Antimicrob. Chemother., 37: 117-126.
11. Gibaldi, M and Perrier, D (1982). Methods of residuals. Pharmacokinetics, (2nd Edn.), New York, Marcel Dekker Inc., PP: 433-444.
12. Giles, CJ; Magonigle, RA; Grimshaw, WTR; Tanner, AC; Risk, JE; Lynch, MJ and Rice, R (1991). Clinical pharmacokinetics of parenterally administered danofloxacin in cattle. J. Vet. Pharmacol. Ther., 14: 400-410.
13. Gips, M and Soback, S (1996). Norfloxacin nicotinate pharmacokinetics in unweaned and weaned calves. J. Vet. Pharmacol. Ther., 19: 130-134.
14. Ito, T; Yano, I; Masuda, S; Hashimoto, Y and Inui, K (1999). Distribution characteristics of levofloxacin and grepafloxacin in rat kidney. Pharmacol. Res., 16: 534-539.
15. Kaartinen, L; Salonen, M; Alli, L and Pyorala, S (1995). Pharmacokinetics of enrofloxacin after single intravenous, intramuscular and subcutaneous injections in lactating cows. J. Vet. Pharmacol. Ther., 18: 357-362.
16. Klesel, N; Geweniger, KH; Koletzki, P; Isert, D; Limbert, M; Markus, A; Riess, G; Schramm, H and Iyer, P (1995). Chemotherapeutic activity of levofloxacin (HR 355, DR-3355) against systemic and localized infections in laboratory animals. J. Antimicrob. Chemother., 35: 805-819.
17. Kunin, CM; Dornbus, RJ and Finland, M (1959). Distribution and excretion of tetracycline analogies in normal young man. J. Clin. Invest., 38: 1950-1963.
18. Langtry, HD and Lamb, HM (1998). Levofloxacin: its use in infections of the respiratory tract, skin, soft tissues and urinary tract. Drugs. 56: 487-515.
19. North, DS; Fish, DN and Redington, JJ (1998). Levofloxacin, a second-generation fluoroquinolone. Pharmacotherapy. 18: 915-935.
20. Schneider, M; Valle, M; Woehrle, F and Boisrame, B (2004). Pharmacokinetics of marbofloxacin in lactating cows after repeated intramuscular administrations and pharmacodynamics against mastitis isolated strains. J. Dairy Sci., 87: 202-211.
21. Shem-Tov, M; Ziv, G; Glickman, A and Saran, A (1997). Pharmacokinetics and penetration of marbofloxacin from blood into milk of cows and ewes. J. Vet. Med. Assoc., 44: 511-519.
22. TerHune, TN; Skogerboe, TC; Shostorm, VK and Weigel, DJ (2005). Comparison of pharmacokinetics of danofloxacin and enrofloxacin in calves challenged with Mannheimia haemolytica. Am. J. Vet. Res., 66: 342-349.