Hepatic steatosis in chronic hepatitis B patients is associated with metabolic factors more than viral factors

Journal of Gastroenterology and Hepatology (Australia)

Volumn 23, Issue 7 PT1, 2008, Pages 1082-1088

  Peng, Dandan ^b   Han, Ying ^c   Ding, Huiguo ^c   Wei, Lai ^a,b  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Fibrosis; Hepatitis B virus; Necroinflammation; Steatosis

Indexed keywords

ALANINE AMINOTRANSFERASE;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; FATTY LIVER; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HISTOPATHOLOGY; HUMAN; LABORATORY DIAGNOSIS; LIVER BIOPSY; LIVER FIBROSIS; LIVER METABOLISM; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; UNIVARIATE ANALYSIS; VIRUS INFECTION;

EID: 47649133015     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2008.05478.x     Document Type: Article

References (27)

1. Angulo P. Nonalcoholic fatty liver disease. N. Engl. J. Med. 2002 346 : 1221 31.
2. Sass DA, Chang P, Chopra KB. Nonalcoholic fatty liver disease: a clinical review. Dig. Dis. Sci. 2005 50 : 171 80.
3. Asselah T, Rubbia-Brandt L, Marcellin P, Negro F. Steatosis in chronic hepatitis C: why does it really matter? Gut 2006 55 : 123 30.
4. World Health Organization. Hepatitis B Fact Sheet No. 204. Cited 10 Jan 2007. Available from URL: http://www.who.int/mediacentre/factsheets/fs204/en.
5. Asselah T, Boyer N, Guimont MC et al. Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C. Gut 2003 52 : 1638 43.
6. Altlparmak E, Koklu S, Yalinkilic M et al. Viral and host causes of fatty liver in chronic hepatitis B. World J. Gastroenterol. 2005 11 : 3056 9.
7. Thomopoulos KC, Arvaniti V, Tsamantas AC et al. Prevalence of liver steatosis in patients with chronic hepatitis B: a study of associated factors and of relationship with fibrosis. Eur. J. Gastroenterol. Hepatol. 2006 18 : 233 7.
8. Malhotra V, Sakhuja P, Gondal R, Sarin SK, Siddhu M, Dutt N. Histological comparison of chronic hepatitis B and C in an Indian population. Trop. Gastroenterol. 2000 21 : 20 1.
9. Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Host- and disease-specific factors affecting steatosis in chronic hepatitis C. J. Hepatol. 1998 29 : 198 206.
10. Czaja AJ, Carpenter HA. Sensitivity, specificity, and predictability of biopsy interpretations in chronic hepatitis. Gastroenterology 1993 105 : 1824 32.
11. Bondini S, Gramlich T, Ramsey L et al. The impact of non-alcoholic fatty liver disease (NAFLD) on chronic hepatitis B. Hepatology 2006 44 (S1 655A.
12. Tsochatzis E, Papatheodoridis GV, Manesis EK, Chrysanthos N, Kafiri G, Archimandritis AJ. Hepatic steatosis in chronic hepatitis B (CHB) is due to host metabolic factors. Hepatology 2006 44 (S1 A652 3.
13. American Gast Roenterological Association. American Gastroenterological Association Medical Position statement: nonalcoholiic fatty liver disease. Gastroenterology 2002 123 : 1702 4.
14. Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981 1 : 431 5.
15. Fan JG, Zhu J, Li XJ et al. Fatty liver and the metabolic syndrome among Shanghai adults. J. Gastroenterol. Hepatol. 2005 20 : 1825 32.
16. Lonardo A, Loria P, Adinolfi LE, Carulli N, Ruggiero G. Hepatitis C and steatosis: a reappraisal. J. Viral Hepat. 2006 13 : 73 80.
17. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006 444 : 840 6.
18. Meek SE, Nair KS, Jensen MD. Insulin regulation of regional free fatty acid metabolism. Diabetes 1999 48 : 10 14.
19. Gordon A, McLean CA, Pedersen JS, Bailey MJ, Roberts SK. Hepatic steatosis in chronic hepatitis B and C: predictors, distribution and effect on fibrosis. J. Hepatol. 2005 43 : 38 44.
20. Weston SR, Leyden W, Murphy R et al. Racial and ethnic distribution of nonalcoholic fatty liver in persons with newly diagnosed chronic liver disease. Hepatology 2005 41 : 372 9.
21. Omagari K, Kadokawa Y, Masuda J et al. Fatty liver in non-alcoholic non-overweight Japanese adults: incidence and clinical characteristics. J. Gastroenterol. Hepatol. 2002 17 : 1098 105.
22. Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV and visceral obesity. Hepatology 2001 33 : 1358 64.
23. Poynard T, Ratziu V, McHutchison J et al. Effect of treatment with peginterferon or interferon alfa-2b and Ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003 38 : 75 85.
24. Hui JM, Sud A, Farrell GC et al. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression. Gastroenterology 2003 125 : 1695 704.
25. Westin J, Nordlinder H, Lagging M, Norkrans G, Wejstal R. Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients. J. Hepatol. 2002 37 : 837 42.
26. Ohata K, Hamasaki K, Toriyama K et al. Hepatic steatosis is a risk factor for hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Cancer 2003 15 97 3036 43.
27. Antunez I, Aponte N, Fernandez-Carbia A, Rodriguez-Perez F, Toro DH. Steatosis as a predictive factor for treatment response in patients with chronic hepatitis C. P. R. Health Sci. J. 2004 23 (Suppl 2 57 60.