Hepatic steatosis in chronic hepatitis B and C: Predictors, distribution and effect on fibrosis

Journal of Hepatology

Volumn 43, Issue 1, 2005, Pages 38-44

  Gordon, Adam ^a   McLean, Catriona A ^a   Pedersen, John S ^a   Bailey, Michael J ^b   Roberts, Stuart K ^a  

^a ALFRED HOSPITAL   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Fibrosis; Hepatitis; Steatosis

Indexed keywords

C PEPTIDE; GLUCOSE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE COURSE; FATTY LIVER; FEMALE; GENOTYPE; HEPATITIS B; HEPATITIS C; HISTOLOGY; HUMAN; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; WAIST CIRCUMFERENCE;

ADULT; AGING; ALCOHOL DRINKING; ANTHROPOMETRY; BLOOD GLUCOSE; C-PEPTIDE; DISEASE PROGRESSION; FATTY LIVER; FEMALE; GENOTYPE; HEPACIVIRUS; HEPATITIS B, CHRONIC; HEPATITIS C, CHRONIC; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

EID: 20444426467     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.01.031     Document Type: Article

References (36)

1. P.J. Scheuer, P. Ashrafzdeh, S. Sherlock, D. Brown, and G.M. Dusheiko The pathology of hepatitis C Hepatology 15 1992 567 571
2. N. Bach, S.N. Thung, and F. Schaffner The histological features of chronic hepatitis C and autoimmune hepatitis Hepatology 15 1992 572 577
3. M.A. Gerber, K. Krawczynski, M.J. Alter, R.E. Sampliner, and H.S. Margolis Histopathology of community acquire chronic hepatitis C Mod Pathol 5 1992 483 486
4. J.M. Roberts, J.W. Searle, and W.G.E. Cooksley Histological patterns of prolonged hepatitis C infection Gastroenterol Jpn 28 1993 901 905
5. J.H. Lefkowitch, E.R. Schiff, G.L. Davis, R.P. Perrillo, K. Lindsay, and H.C. Bodenheimer Pathological diagnosis of chronic hepatitis C: a multicenter comparative study with chronic hepatitis B Gastroenterology 104 1993 595 603
6. A.J. Czaja, and H.A. Carpenter Sensitivity, specificity, and predictability of biopsy interpretations in chronic hepatitis Gastroenterology 105 1993 1824 1832
7. A.J. Sanyal, M.J. Contos, R.K. Sterling, V.A. Luketic, M.L. Shiffman, and R.T. Stravitz Nonalcoholic fatty liver disease in patients with hepatitis C is associated with features of the metabolic syndrome Am J Gastroenterol 98 2003 2064 2071
8. L.E. Adinolfi, M. Gambardella, A. Andreana, M.F. Tripodi, R. Utili, and G. Ruggiero Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity Hepatology 33 2001 1359 1364
9. M.G. Ghany, D.E. Kleiner, H. Alter, E. Doo, F. Khokar, and K. Promrat Progression of fibrosis in chronic hepatitis C Gastroenterology 124 2003 97 104
10. S.D. Ryder Progression of hepatic fibrosis in patients with hepatitis C: a prospective repeat liver biopsy study Gut 53 2004 451 455
11. L. Castera, C. Hezode, F. Roudot-Thoraval, A. Bastie, E.S. Zafrani, and J.M. Pawlotsky Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies Gut 52 2003 288 292
12. A. Monto, J. Alonzo, Watson, C. Grunfield, and T.L. Wright Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus and alcohol Hepatology 36 2002 729 736
13. J.M. Hui, J. Kench, G.C. Farrell, R. Lin, D. Samarasinghe, and C. Liddle Genotype-specific mechanisms for hepatic steatosis in chronic hepatitis C infection J Gastroenterol Hepatol 17 2002 873 881
14. S. Mihm, A. Fayyazi, H. Hartmann, and G. Ramadori Analysis of histological manifestations of chronic hepatitis C virus infection with respect to virus genotype Hepatology 25 1997 735 739
15. L. Rubbia-Brandt, R. Quadri, K. Abid, E. Giostra, P.J. Male, and G. Mentha Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3 J Hepatol 33 2000 106 115
16. L.M. Lagging, E.G. Clementina, J. Westin, R. Wejstal, G. Norkrans, and A.P. Dhillon Comparison of serum hepatitis C virus RNA and core antigen concentrations and determination of whether levels are associated with liver histology or affected by specimen storage time J Clin Microbiol 40 2002 4224 4229
17. H. Fujie, H. Yotsuyanagi, K. Moriya, Y. Shintani, T. Tsutsumi, and H. Yotsuyanagi Steatosis and intrahepatic hepatitis C virus in chronic hepatitis J Med Virol 59 1999 141 145
18. H. Lerat, M. Honda, M.R. Beard, K. Loesch, J. Sun, and Y. Yang Steatosis and liver cancer in transgenic mice expressing structural and nonstructural proteins of hepatitis C virus Gastroenterology 122 2002 352 365
19. P. Bedossa, and T. Pornard An algorithm for the grading of activity in chronic hepatitis C Hepatology 24 1996 289 293
20. E. Brunt, C. Janney, A. Di Bisceglie, B. Neuschwander-Tetri, and B. Bacon Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions Am J Gastroenterol 94 1999 2467 2474
21. D.R. Mathews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
22. J.B. Dixon, P.S. Bhathal, and P.E. O'Brien On alcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese Gastroenterology 121 2001 91 100
23. K. Tobe, T. Ogura, C. Tsukamoto, A. Imai, K. Matsuura, and Y. Iwasaki Relationship between serum leptin and fatty liver in Japanese male adolescent university students Am J Gastroenterol 94 1999 3328 3335
24. M. Romero-Gomez, V.M. Castellano-Megias, L. Grande, J.A. Irles, M. Cruz, and M.C. Nogales Serum leptin levels correlate with hepatic steatosis in chronic hepatitis C Am J Gastroenterol 98 2003 1135 1141
25. M. Roden, C. Anderwald, C. Furnsinn, W. Waldhausl, and A. Lohninger Effects of short-term leptin exposure on triglyceride deposition in rat liver Hepatology 32 2000 1045 1049
26. C. Couillard, P. Mauriege, D. Prud'homme, A. Nadeau, A. Tremblay, and C. Bouchard Plasma leptin concentrations: gender differences and associations with metabolic risk factors for cardiovascular disease Diabetologia 40 1997 1178 1184
27. E. Giannini, P. Ceppa, F. Botta, L. Mastracci, P. Romangnoli, and I. Comino Leptin has no role in determining severity of steatosis and fibrosis in patients with chronic hepatitis C Am J Gastroenterol 95 2000 3211 3217
28. J. Crespo, M. Rivero, E. Fabrega, A. Cayon, J.A. Amado, and M.T. Garcia-Unzeta Plasma leptin and TNF-alpha levels in chronic hepatitis C patients and their relationship to hepatic fibrosis Dig Dis Sci 47 7 2002 1604 1610
29. F. Farinati, R. Cardin, N. De Maria, G. Della Libera, C. Marafin, and E. Lecis Iron storage, lipid peroxidation and glutathione turnover in chronic anti-HCV positive hepatitis J Hepatol 22 1995 449 456
30. C.M. Leevy Fatty liver: a study of 270 patients with biopsy proven fatty liver and a review of the literature Medicine 41 1962 249 276
31. J.P. Ong, Z.M. Younossi, C. Speer, A. Olano, T. Gramlich, and N. Boparai Chronic hepatitis C and superimposed non-alcoholic fatty liver disease Liver 21 2001 266 271
32. T. Asselah, N. Boyer, M-C. Guimont, D. Cazals-Hatem, F. Tubach, and K. Nahon Liver fibrosis is not associated with steatosis but with necroinflammation in French patients with chronic hepatitis C Gut 52 2003 1638 1643
33. K. Patel, A. Muir, and J. McHutchison A link between leptin and steatosis in chronic hepatitis C? Time to weigh up the fats Am J Gastroenterol 98 2003 952 954
34. V. Ratziu, M. Saboury, and T. Poynard Worsening of steatosis and fibrosis progression Gut 52 2003 1386 1387
35. J. Hui, A. Sud, G. Farrell, P. Bandara, K. Byth, and J. Kench Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression Gastroenterology 125 2003 1695 1704
36. F. Liaw, D.I. Tai, C.M. Chu, and T.J. Chen The development of cirrhosis in patients with chronic type B hepatitis: a prospective study Hepatology 8 1988 493 496