Beneficial effects of Kampo medicine Inchin-ko-to on liver function and regeneration after hepatectomy in rats

Hepatology Research

Volumn 38, Issue 8, 2008, Pages 818-824

  Ogasawara, Takashi ^a   Morine, Yuji ^a   Ikemoto, Tetsuya ^a   Imura, Satoru ^a   Shimada, Mitsuo ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Hepatic stellate cells; Inchin ko to; Liver regeneration; Small for size graft

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CYCLINE; HEME OXYGENASE 1; INCHIN KO TO; KAMPO;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER FUNCTION; LIVER REGENERATION; LIVER RESECTION; LIVER WEIGHT; MALE; NONHUMAN; POSTOPERATIVE PERIOD; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RAT; SURVIVAL TIME; WISTAR RAT;

EID: 47649118592     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2008.00344.x     Document Type: Article

References (38)

1. Diehl AM, Rai RM. Liver regeneration 3: Regulation of signal transduction during liver regeneration. FASEB J 1996; 10: 215-27.
2. Tuczek HV, Rabes H. Verlust der Proliferationsfähigkeit der Hepatozyten nach subtotalen Hepatektomie (in German). Experientia 1971; 27: 526.
3. Emond J, Capron-Laudereay M, Meriggi F, Bernuau J, Reynes M, Houssin D. Extent of hepatectomy in the rat: Evaluation of basal condition and effect of therapy. Eur Surg Res 1989; 21: 251-9.
4. Fukuchi T, Hirose H, Onitsuka A et al. Effects of portal-systemic shunt following 90% partial hepatectomy in rats. J Surg Res 2000; 89: 126-31.
5. Mochida S, Ogata I, Hirata K et al. Provocation of massive hepatic necrosis by endotoxin after partial hepatectomy in rats. Gastroenterology 1990; 99: 771-7.
6. Calley MP, Kamai T, Flye MW. Kupffer cell tumor necrosis factor-á production is suppressed during liver regeneration. J Surg Res 1991; 50: 515-19.
7. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A. Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol 1995; 146: 1220-34.
8. Panis Y, McMullan DM, Emond JC. Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection. Surgery 1997; 121: 142-9.
9. Andiran F, Ayhan A, Tanyel FC, Abbasoglu O, Sayek I. Regenerative capacities of normal and cirrhotic livers following 70% hepatectomy in rats and the effect of á-tocopherol on cirrhotic regeneration. J Surg Res 2000; 89: 184-8.
10. Oda H, Miyake H, Iwata T, Kusumoto K, Rokutan K, Tashiro S. Geranylgeranylacetone Suppresses Inflammatory Responses and Improves Survival After Massive Hepatectomy in Rats. J Gastrointestinal Surg 2002; 6: 464-73.
11. Komiyama T, Tsukui M, Oshio H, Studies of 'Inchinko'. I. Capillarisin, a new choleretic substance. Yakugaku Zasshi 1976; 96: 841-54.
12. Okuno I, Uchida K, Nakamura M, Sakurai K. Studies on choleretic constitutions in Artemisia capillaris THUNB. Chem Pharmacol Bull 1988; 36: 769-75.
13. Yamamoto M, Ogawa K, Morita M, Fukuda K, Komatsu Y. The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor b1. Hepatology 1996; 23: 552-9.
14. Yamamoto M, Miura N, Ohtake N et al. Genipin, a metabolite derived from the herbal medicine Inchinko-to, and suppression of Fas-induced lethal liver apoptosis in mice. Gastroenterology 2000; 118: 380-9.
15. Inao M, Mochida S, Matsui A et al. Japanese herbal medicine Inchin-ko-to as a therapeutic drug for liver fibrosis. J Hepatology 2004; 41: 584-91.
16. Shoda J, Miura T, Utsunomiya H et al. Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in Rat Liver. Hepatology 2004; 39: 167-78.
17. Higgins GM, Anderson RM. Experimental pathology of the liver. I. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 1931; 12: 186-202.
18. Kubota T, Takabe K, Yang M et al. Minimum sizes for remnant and transplanted livers in rat. J Hepatobiliary Pancreat Surg 1997; 4: 398-404.
19. Gaub J, Iversen J. Rat liver regeneration after 90% partial hepatectomy. Hepatology 1984; 4: 902-4.
20. Xu X, Man K, Zheng SS et al. Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival. Liver Transpl 2006; 12: 621-7.
21. Franco-Gou R, Rosello-Catafau J, Casillas-Ramirez A et al. How ischaemic preconditioning protects small liver grafts. J Pathol 2006; 208: 62-73.
22. Glanemann M, Schirmeier A, Lippert S, Langrehr JM, Neuhaus P, Nussler AK. Cobalt-protoporphyrin induced heme oxygenase overexpression and its impact on liver regeneration. Transplant Proc 2005; 37: 3223-5.
23. Wang XH, Wang K, Zhang F et al. Heme oxygenase-1 alleviates ischemia/ reperfusion injury in aged liver. World J Gastroenterol 2005; 11: 690-4.
24. Wang XH, Wang K, Zhang F et al. Alleviating ischemia-reperfusion injury in aged rat liver by induction of heme oxygenase-1. Transplant Proc 2004; 36: 2917-23.
25. Aoki T, Jin Z, Nishino N et al. Intrasplenic transplantation of encapsulated hepatocytes decreases mortality and improves liver functions in fulminant hepatic failure from 90% partial hepatectomy in rats. Transplantation 2005; 79: 783-90.
26. Nagamine K, Kubota T, Togo S, Nagashima Y, Mori M, Shimada H. Beneficial effect of hyperbaric oxygen therapy on liver regeneration after 90% hepatectomy in rats. Eur Surg Res 2004; 36: 350-6.
27. Okada K, Shoda J, Kano M et al. Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol 2007; 292: 1450-63.
28. Fondevila C, Shen XD, Tsuchiyashi S et al. Biliverdin therapy protects rat livers from ischemia and reperfusion injury. Hepatology 2004; 40: 1333-41.
29. Yang ZF, Tsui TY, Ho DW, Tang TC, Fan ST. Heme oxygenase-1 potentiates the survival of small-for-size liver graft. Liver Transpl 2004; 10: 784-93.
30. Chen YC, Gines P, Yang J et al. Increased vascular heme oxygenase-1 expression contributes to arterial vasodilation in experimental cirrhosis in rats. Hepatology 2004; 39: 1075-87.
31. Wang LS, Chen YW, Li DG, Lu HM. Arg-gly-asp-mannose-6-phosphate inhibits activation and proliferation of hepatic stellate cells in vitro. World J Gastroenterol 2006; 12: 1303 -7.
32. Patella S, Phillips DJ, Tchongue J, de Kretser DM, Sievert W. Follistatin attenuates early liver fibrosis: Effects on hepatic stellate cell activation and hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol 2006; 290: 137-44.
33. Oakley F, Meso M, Iredale JP etal. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 2005; 128: 108-20.
34. Fukuhara Y, Hirasawa A, Li XK et al. Gene expression profile in the regenerating rat liver after partial hepatectomy. J Hepatology 2003; 38: 784-92.
35. Nagano Y, Nagahon K, Yoshiro F et al. Gene expression profile analysis of regeneration liver after portal vein ligation in rats by cDNA microarray system. Liver Int 2004; 24: 253-8.
36. Rajagopalan P, Berthiaume F, Tilles AW, Toner M, Yarmush ML. Selective enhancement of cytochrome p-450 activity in rat hepatocytes by in vitro heat shock. Tissue Eng 2005; 11: 1527-34.
37. Arai M, Yokosuka O, Chiba T et al. Gene expression profiling reveals the mechanism and pathophysiology of mouse liver regeneration. J Biol Chem 2003; 278: 29813-18.
38. Togo S, Makino H, Kobayashi T et al. Mechanism of liver regeneration after partial hepatectomy using mouse cDNA microarray. J Hepatol 2004; 40: 464-71.