Purinergic P2X receptors facilitate inhibitory GABAergic and glycinergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus

Brain Research

Volumn 1224, Issue , 2008, Pages 53-62

  Jameson, Heather S ^a   Pinol, Ramon A ^a   Mendelowitz, David ^a  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

ATP; GABA; Glycine; Heart rate; Nucleus ambiguus; Purinergic

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; GLYCINE RECEPTOR; PURINERGIC P2X RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; VOLTAGE GATED CALCIUM CHANNEL;

AMBIGUUS NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; BRAIN SLICE; CONTROLLED STUDY; EXPERIMENTAL RAT; IN VITRO STUDY; NEUROTRANSMISSION; NONHUMAN; PARASYMPATHETIC NERVE CELL; PRIORITY JOURNAL; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; GAMMA-AMINOBUTYRIC ACID; GLYCINE; HEART; INHIBITORY POSTSYNAPTIC POTENTIALS; MEDULLA OBLONGATA; NEURAL INHIBITION; NEURONS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SYNAPTIC TRANSMISSION; VAGUS NERVE;

RATTUS;

EID: 47649114845     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.06.012     Document Type: Article

References (22)

1. Bardoni R., Goldstein P.A., Lee C.J., Gu J.G., and MacDermott A.B. ATP P2X receptors mediate fast synaptic transmission in the dorsal horn of the rat spinal cord. J Neurosci 17 (1997) 5297-5304
2. Burnstock G., and Wood J.N. Purinergic receptors: their role in nociception and primary afferent neurotransmission. Curr Opin Neurobiol 6 (1996) 526-532
3. Edwards F.A., Robertson S.J., and Gibb A.J. Properties of ATP receptor-mediated synaptic transmission in the rat medial habenula. Neuropharmacology 36 (1997) 1253-1268
4. Evans R.J., Lewis C., Virginio C., Lundstrom K., Buell G., Surprenant A., and North R.A. Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol 497 Pt 2 (1996) 413-422
5. Gomez-Villafuertes R., Gualix J., and Miras-Portugal M.T. Single GABAergic synaptic terminals from rat midbrain exhibit functional P2X and dinucleotide receptors, able to induce GABA secretion. J Neurochem 77 (2001) 84-93
6. Griffioen K.J., Gorini C., Jameson H., and Mendelowitz D. Purinergic P2X receptors mediate excitatory transmission to cardiac vagal neurons in the nucleus ambiguus after hypoxia. Hypertension 50 (2007) 75-81
7. Griffioen K.J., Kamendi H.W., Gorini C.J., Bouairi E., and Mendelowitz D. Reactive oxygen species mediate central cardiorespiratory network responses to acute intermittent hypoxia. J Neurophysiol 97 (2007) 2059-2066
8. Huang Z.G., Griffioen K.J., Wang X., Dergacheva O., Kamendi H., Gorini C., and Mendelowitz D. Nicotinic receptor activation occludes purinergic control of central cardiorespiratory network responses to hypoxia/hypercapnia. J Neurophysiol 98 (2007) 2429-2438
9. Hugel S., and Schlichter R. Presynaptic P2X receptors facilitate inhibitory GABAergic transmission between cultured rat spinal cord dorsal horn neurons. J Neurosci 20 (2000) 2121-2130
10. Jameson H.S., Pinol R.A., Kamendi H., and Mendelowitz D. ATP facilitates glutamatergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Brain Res 1201 (2008) 88-92
11. Jang I.S., Rhee J.S., Kubota H., and Akaike N. Developmental changes in P2X purinoceptors on glycinergic presynaptic nerve terminals projecting to rat substantia gelatinosa neurones. J Physiol 536 (2001) 505-519
12. Jo Y.H., and Role L.W. Cholinergic modulation of purinergic and GABAergic co-transmission at in vitro hypothalamic synapses. J Neurophysiol 88 (2002) 2501-2508
13. Jo Y.H., and Schlichter R. Synaptic corelease of ATP and GABA in cultured spinal neurons. Nat Neurosci 2 (1999) 241-245
14. Kamendi H.W., Cheng Q., Dergacheva O., Frank J.G., Gorini C., Jameson H.S., Pinol R.A., Wang X., and Mendelowitz D. Recruitment of excitatory serotonergic neurotransmission to cardiac vagal neurons in the nucleus ambiguus post hypoxia and hypercapnia. J Neurophysiol 99 (2008) 1163-1168
15. Nakatsuka T., Furue H., Yoshimura M., and Gu J.G. Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord. J Neurosci 22 (2002) 1228-1237
16. Neff R.A., Humphrey J., Mihalevich M., and Mendelowitz D. Nicotine enhances presynaptic and postsynaptic glutamatergic neurotransmission to activate cardiac parasympathetic neurons. Circ Res 83 (1998) 1241-1247
17. Neff R.A., Simmens S.J., Evans C., and Mendelowitz D. Prenatal nicotine exposure alters central cardiorespiratory responses to hypoxia in rats: implications for sudden infant death syndrome. J Neurosci 24 (2004) 9261-9268
18. North R.A., and Barnard E.A. Nucleotide receptors. Curr Opin Neurobiol 7 (1997) 346-357
19. Rhee J.S., Wang Z.M., Nabekura J., Inoue K., and Akaike N. ATP facilitates spontaneous glycinergic IPSC frequency at dissociated rat dorsal horn interneuron synapses. J Physiol 524 Pt 2 (2000) 471-483
20. Sorimachi M., Ishibashi H., Moritoyo T., and Akaike N. Excitatory effect of ATP on acutely dissociated ventromedial hypothalamic neurons of the rat. Neuroscience 105 (2001) 393-401
21. Wang Z.M., Katsurabayashi S., Rhee J.S., Brodwick M., and Akaike N. Substance P abolishes the facilitatory effect of ATP on spontaneous glycine release in neurons of the trigeminal nucleus pars caudalis. J Neurosci 21 (2001) 2983-2991
22. Wollmann G., Acuna-Goycolea C., and van den Pol A.N. Direct excitation of hypocretin/orexin cells by extracellular ATP at P2X receptors. J Neurophysiol 94 (2005) 2195-2206