Influence of load of hepatitis A virus on disease severity and its relationship with clinical manifestations in patients with hepatitis A

Journal of Gastroenterology and Hepatology (Australia)

Volumn 20, Issue 8, 2005, Pages 1165-1175

  Sainokami, Shigehiko ^a,c   Abe, Koichi ^a   Ishikawa, Kazuyoshi ^b   Suzuki, Kazuyuki ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b IWATE PREFECTURAL UNIVERSITY   (Japan)

^c Mizusawa City Hospital   (Japan)

Author keywords

Acute hepatitis A; C reactive protein; Extrahepatic manifestation; Real time polymerase chain reaction; Thrombocytopenia

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; PROTHROMBIN;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEPATITIS A; HEPATITIS A VIRUS; HUMAN; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; THROMBOCYTE COUNT; VIRUS LOAD;

EID: 27744471606     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2005.03908.x     Document Type: Article

References (35)

1. Robertson BH, Jansen RW, Khanna B et al. Genetic relatedness of hepatitis A virus strains recovered from different geographic regions. J. General Virol 1992; 73: 1365-77.
2. Keeffe EB. Is hepatitis A more severe in patients with chronic hepatitis B and other chronic liver diseases? Am. J. Gastroenterol. 1995; 90: 201-5.
3. Huo TI, Wu JC, Chiu CF, Lee SD. Severe hyperbilirubinemia due to acute hepatitis A superimposed on a chronic hepatitis B carrier with glucose-6-phosphate dehydrogenase deficiency. Am. J. Gastroenterol. 1996; 91: 158-9.
4. Domenech P, Palomeque A, Martinez-Gutierrez A, Vinolas N, Vela E, Jimenez R. Severe aplastic anemia following hepatitis A. Acta Haematol. 1986; 76: 227-9.
5. Cohen O, Mevorach D, Ackerman Z, Oren R. Thrombocytopenic purpura as a manifestation of acute hepatitis A. J. Clin. Gastroenterol. 1993; 17: 166-7.
6. Simmons J, Stein L, Kaufman A. Pure red cell aplasia and hepatitis A. South Med. J. 1993; 86: 1274-6.
7. Mourani S, Dobbs SM, Genta RM, Tandon AK, Yoffe B. Hepatitis A virus-associated cholecystitis. Ann. Intern. Med. 1994; 120: 398-400.
8. Davis TV, Keeffe EB. Acute pancreatitis associated with acute hepatitis A. Am. J. Gastroenterol. 1992; 87: 1648-50.
9. Chio F Jr, & Bakir AA. Acute renal failure in hepatitis A. Int. J. Artif. Organs 1992; 15: 413-16.
10. Ilan Y, Hillman M, Oren R, Zlotogorski A, Shouval D. Vasculitis and cryoglobulinemia associated with persisting cholestatic hepatitis A virus infection. Am. J. Gastroenterol. 1990; 85: 586-7.
11. Pelletier G, Elghozi D, Trepo C, Laverdant C, Benhamou JP. Mononeuritis in acute viral hepatitis. Digestion 1985; 32: 53-6.
12. Safadi R, Ben-Hur T, Shouval D. Mononeuritis multiplex: a rare complication of acute hepatitis A. Liver 1996; 16: 288-9.
13. Tabor E. Guillain-Barre syndrome and other neurologic syndromes in hepatitis A, B, and non-A, non-B. J. Med. Virol. 1987; 21: 207-16.
14. Davis LE, Brown JE, Robertson BH, Khanna B, Polish LB. Hepatitis A post-viral encephalitis. Acta Neurol. Scand. 1993; 87: 67-9.
15. Fujiwara K, Yokosuka O, Fukai K, Imazeki F, Saisho H, Omata M. Analysis of full-length hepatitis A virus genome in sera from patients with fulminant and self-limited acute type A hepatitis. J. Hepatol. 2001; 35: 112-19.
16. Fujiwara K, Yokosuka O, Ehata T et al. Association between severity of type A hepatitis and nucleotide variations in the 5′ non-translated region of hepatitis A virus RNA: strains from fulminant hepatitis have fewer nucleotide substitutions. Gut 2002; 51: 82-8.
17. Fujiwara K, Yokosuka O, Ehata T, Imazeki F, Saisho H. PCR-SSCP analysis of 5′-nontranslated region of hepatitis A viral RNA. comparison with clinicopathological features of hepatitis A. Dig. Dis. Sci. 2000; 45: 2422-7.
18. Rezende G, Roque-Afonso AM, Samuel D et al. Viral and clinical factors associated with the fulminant course of hepatitis A infection. Hepatology 2003; 38: 613-18.
19. Normann A, Jung C, Vallbracht A, Flehmig B. Time course of hepatitis A viremia and viral load in the blood of human hepatitis A patients. J. Med. Virol. 2004; 72: 10-16.
20. Kwok S, Higuchi R. Avoiding false positives with PCR. Nature 1989; 339: 237-8.
21. Robertson BH, Jansen RW, Khanna B et al. Genetic relatedness of hepatitis A virus strains recovered from different geographical regions. J. General Virol. 1992; 73: 1365-77.
22. Brechot C, Bernuau J, Thiers V et al. Multiplication of hepatitis B virus in fulminant hepatitis B. Br. Med. J. (Clin. Res. Ed.) 1984; 288: 270-71.
23. Schaefer E, Koeppen H, Wirth S. Low level virus replication in infants with vertically transmitted fulminant hepatitis and their anti-HBe positive mothers. Eur. J. Pediatr. 1993; 152: 581-4.
24. Wright TL, Mamish D, Combs C et al. Hepatitis B virus and apparent fulminant non-A, non-B hepatitis. Lancet 1992; 339: 952-5.
25. Sánchez G, Pintó RM, Bosch A. A novel CD4+ T-helper lymphocyte epitope in the VP3 protein of hepatitis A virus. J. Med. Virol. 2004; 72: 525-32.
26. Bosch A, Gonzalez-Dankaart JF, Haro I, Gajardo R, Ferez JA, Pinto RM. A new continuous epitope of hepatitis A virus. J. Med. Virol. 1998; 54: 95-102.
27. Fujiwara K, Yokosuka O, Imazeki F et al. Analysis of the genotype-determining region of hepatitis A viral RNA in relation to disease severities. Hepatol. Res. 2003; 25: 124-34.
28. Scott JX, Gnananayagam EJ, Gupta S, Simon A, Mukhopadhya A. Thrombocytopenic purpura as initial presentation of acute hepatitis A. Indian J. Gastroenterol. 2003; 22: 192-3.
29. Avci Z, Turul T, Catal F et al. Thrombocytopenia and emperipolesis in a patient with hepatitis A infection. Pediatr. Hematol. Oncol. 2002; 19: 67-70.
30. Ertem D, Acar Y, Pehlivanoglu E. Autoimmune complications associated with hepatitis A virus infection in children. Pediatr. Infect. Dis. J. 2001; 20: 809-11.
31. Ertem D, Acar Y, Aral C, Pehlivanoglu E. Thrombotic and thrombocytopenic complications secondary to hepatitis A infection in children. Am. J. Gastroenterol. 1999; 94: 3653-5.
32. Watanabe M, Shibuya A, Okuno J, Maeda T, Tamama S, Saigenji K. Hepatitis A virus infection associated with hemophagocytic syndrome: report of two cases. Intern. Med. 2002; 41: 1188-92.
33. Busch FW, de Vos S, Flehmig B, Herrmann F, Sandler C, Vallbracht A. Inhibition of in vitro hematopoiesis by hepatitis A virus. Exp. Hematol. 1987; 15: 978-82.
34. Atono Y, Sata M, Tanikawa K. Kinetics of C-reactive protein in acute viral hepatitis. Gastroenterol. Jpn 1989; 24: 655-62.
35. Kindmark CO, Laurell CB, Iwarson S, Persson K. Sequential changes of the plasma-protein pattern in cases of hepatitis A. Ups. J. Med. Sci. 1988; 93: 233-44.